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Generic acquisition protocol for quantitative MRI of the spinal cord

Julien Cohen-Adad, Eva Alonso Ortiz, Mihael Abramovic, Carina Arneitz, Nicole Atcheson, Laura Barlow, Robert L. Barry, Markus Barth, Marco Battiston, Christian Büchel, Matthew Budde, Virginie Callot, Anna J. E. Combes, Benjamin De Leener, Maxime Descoteaux, Paulo Loureiro de Sousa, Marek Dostál, Julien Doyon, Adam Dvorak, Falk Eippert, Karla R. Epperson, Kevin S. Epperson, Patrick Freund, Jürgen Finsterbusch, Alexandru Foias, Michela Fratini, Issei Fukunaga, Claudia Angela M. Gandini Wheeler-Kingshott, Giancarlo Germani, Guillaume Gilbert, Federico Giove, Charley Gros, Francesco Grussu, Akifumi Hagiwara, Pierre-Gilles Henry, Tomáš Horák, Masaaki Hori, James Joers, Kouhei Kamiya, Haleh Karbasforoushan, Miloš Keřkovský, Ali Khatibi, Joo-Won Kim, Nawal Kinany, Hagen Kitzler, Shannon Kolind, Yazhuo Kong, Petr Kudlička, Paul Kuntke, Nyoman D. Kurniawan, Slawomir Kusmia, René Labounek, Maria Marcella Laganà, Cornelia Laule, Christine S. Law, Christophe Lenglet, Tobias Leutritz, Yaou Liu, Sara Llufriu, Sean Mackey, Eloy Martinez-Heras, Loan Mattera, Igor Nestrasil, Kristin P. O'Grady, Nico Papinutto, Daniel Papp, Deborah Pareto, Todd B. Parrish, Anna Pichiecchio, Ferran Prados, Àlex Rovira, Marc J. Ruitenberg, Rebecca S. Samson, Giovanni Savini, Maryam Seif, Alan C. Seifert, Alex K. Smith, Seth A. Smith, Zachary A. Smith, Elisabeth Solana, Yuichi Suzuki, George Tackley, Alexandra Tinnermann, Jan Valošek, Dimitri Van De Ville, Marios C. Yiannakas, Kenneth A. Weber, Nikolaus Weiskopf, Richard G. Wise, Patrik O. Wyss and Junqian Xu

Article (2021)

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Quantitative spinal cord (SC) magnetic resonance imaging (MRI) presents many challenges, including a lack of standardized imaging protocols. Here we present a prospectively harmonized quantitative MRI protocol, which we refer to as the spine generic protocol, for users of 3T MRI systems from the three main manufacturers: GE, Philips and Siemens. The protocol provides guidance for assessing SC macrostructural and microstructural integrity: T1-weighted and T2-weighted imaging for SC cross-sectional area computation, multi-echo gradient echo for gray matter cross-sectional area, and magnetization transfer and diffusion weighted imaging for assessing white matter microstructure. In a companion paper from the same authors, the spine generic protocol was used to acquire data across 42 centers in 260 healthy subjects. The key details of the spine generic protocol are also available in an open-access document that can be found at https://github.com/spine-generic/protocols. The protocol will serve as a starting point for researchers and clinicians implementing new SC imaging initiatives so that, in the future, inclusion of the SC in neuroimaging protocols will be more common. The protocol could be implemented by any trained MR technician or by a researcher/clinician familiar with MRI acquisition.

Uncontrolled Keywords

Imaging techniques, Spinal cord diseases

Subjects: 1900 Biomedical engineering > 1900 Biomedical engineering
1900 Biomedical engineering > 1901 Biomedical technology
2500 Electrical and electronic engineering > 2500 Electrical and electronic engineering
Department: Department of Electrical Engineering
Department of Computer Engineering and Software Engineering
Institut de génie biomédical
Research Center: NeuroPoly - Laboratoire de Recherche en Neuroimagerie
Funders: Canada Research Chair in Quantitative Magnetic Resonance Imaging, Canadian Institute of Health Research, Canada Foundation for Innovation, Fonds de Recherche du Québec–Santé, Fonds de Recherche du Québec–Nature et Technologies, CRSNG / NSERC, Canada First Research Excellence Fund (IVADO and TransMedTech), Quebec BioImaging Network, Spinal Research (UK), Wings for Life (Austria), Craig H. Neilsen Foundation (USA) - INSPIRED project, National Institutes of Health (NIH), Instituto Investigación Carlos III (Spain), Czech Health Research Council, Ministry of Health - Czech Republic–conceptual development of research organization, National Imaging Facility and Queensland NMR Network, SpinalCure Australia, European Research Council under the European Union’s Seventh Framework Programme/ERC grant agreement no. 616905, European Union’s Horizon 2020 research and innovation programme, Swiss State Secretariat for Education, Research and Innovation (SERI), ERA-NET NEURON - BMBF, European Union’s Horizon 2020 research and innovation programme, Engineering and Physical Sciences Research Council, Rosetrees Trust (UK), UK Multiple Sclerosis Society, NIHR Biomedical Research Centres, UCLH, Italian Ministry of Health Young Researcher Grant 2013, FISR Project ‘Tecnopolo di nanotecnologia e fotonica per la medicina di precisione’ (funded by MIUR/CNR), TECNOMED project (funded by Regione Puglia), Million Dollar Bike Ride from the University of Pennsylvania, investigator-initiated PREdICT study at the Vall d’Hebron Institute of Oncology (Barcelona), funded by AstraZeneca and CRIS Cancer Foundation, Wellcome Trust (UK), Systems, Technologies and Applications for Radiofrequency and Communications (STARaCOM), Swiss National Science Foundation, Max Planck Society and European Research Council
Grant number: 950-230815, CIHR FDN-143263, 32454, 34824, 28826, 2015-PR-182754, 435897-2013, 5886, 169111, R01EB027779, R00EB016689, P41 EB027061, P30 NS076408, PI18/00823, NV18-04-00159, FNBr, 65269705, FP7/2007-2013, 681094, 15.0137, 01EW1711A & B, 634541, R006032/1, M020533/1, 892/08, 77/2017, GR-2013-02358177, CUP B83B17000010001, CUP B84I18000540002, MDBR-17-123-MPS, 203139/Z/16/Z, PCEFP3_181362/1, ERC StG 758974
PolyPublie URL: https://publications.polymtl.ca/9982/
Journal Title: Nature Protocols (vol. 16, no. 10)
Publisher: Springer Nature
DOI: 10.1038/s41596-021-00588-0
Official URL: https://doi.org/10.1038/s41596-021-00588-0
Date Deposited: 16 Nov 2022 10:13
Last Modified: 21 Feb 2024 11:25
Cite in APA 7: Cohen-Adad, J., Alonso Ortiz, E., Abramovic, M., Arneitz, C., Atcheson, N., Barlow, L., Barry, R. L., Barth, M., Battiston, M., Büchel, C., Budde, M., Callot, V., Combes, A. J. E., De Leener, B., Descoteaux, M., de Sousa, P. L., Dostál, M., Doyon, J., Dvorak, A., ... Xu, J. (2021). Generic acquisition protocol for quantitative MRI of the spinal cord. Nature Protocols, 16(10), 4611-4632. https://doi.org/10.1038/s41596-021-00588-0


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