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Olivier HenryDepartment of Chemical Engineering
Profile in the Directory of Experts of Polytechnique Montréal
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Ansorge, S., Lanthier, S., Transfiguracion, J., Henry, O., & Kamen, A. A. (2011). Monitoring lentiviral vector production kinetics using online permittivity measurements. Biochemical Engineering Journal, 54(1), 16-25. External link
Ansorge, S., Henry, O., Aucoin, M., Voyer, R., Carvell, J. P., & Kamen, A. (2007, June). Monitoring the Cell Size Distribution of Mammalian Cell Cultures Using On-Line Capacitance Measurements [Paper]. 20th ESACT Meeting, Dresden, Germany. External link
Ansorge, S., Henry, O., & Kamen, A. A. (2010). Recent progress in lentiviral vector mass production. Biochemical Engineering Journal, 48(3), 362-377. External link
Ansorge, S., Lanthier, S., Transfiguracion, J., Durocher, Y., Henry, O., & Kamen, A. (2009). Development of a Scalable Process for High-Yield Lentiviral Vector Production by Transient Transfection of Hek293 Suspension Cultures. Journal of Gene Medicine, 11(10), 868-876. External link
Cambay, F., Forest-Nault, C., Dumoulin, L., Seguin, A., Henry, O., Durocher, Y., & De Crescenzo, G. (2020). Glycosylation of Fcγ receptors influences their interaction with various IgG1 glycoforms. Molecular Immunology, 121, 144-158. External link
Cambay, F., Raymond, C., Brochu, D., Gilbert, M., Tu, T. M., Cantin, C., Lenferink, A., Grail, M., Henry, O., De Crescenzo, G., & Durocher, Y. (2020). Impact of IgG1 N-glycosylation on their interaction with Fc gamma receptors. Current Research in Immunology, 1, 23-37. External link
Cambay, F., Henry, O., Durocher, Y., & De Crescenzo, G. (2019). Impact of N-glycosylation on Fcγ receptor / IgG interactions: unravelling differences with an enhanced surface plasmon resonance biosensor assay based on coiled-coil interactions. mAbs, 11(3), 435-452. External link
Dégardin, M., Liberelle, B., Oliverio, R., Baniahmad, S. F., Darviot, C., Largillière, I., Henry, O., Durocher, Y., Banquy, X., Meunier, M., & De Crescenzo, G. (2023). Coiled-coil-based biofunctionalization of 100 nm gold nanoparticles with the trastuzumab antibody for the detection of HER2-positive cancer cells. Langmuir, 39(34), 12235-12247. External link
Durocher, Y., Toussaint, C., & Henry, O. (2018, May). Regulation of recombinant protein expression during CHO pool selection enhances high producer frequency [Paper]. Cell Culture Engineering XVI, Tampa, FL. Unavailable
Forest-Nault, C., Koyuturk, I., Gaudreault, J., Pelletier, A., L'Abbé, D., Cass, B., Bisson, L., Burlacu, A., Delafosse, L., Stuible, M., Henry, O., De Crescenzo, G., & Durocher, Y. (2024). A Biosensor Assay Based on Coiled-Coil-Mediated Human ACE2 Receptor Capture for the Analysis of Its Interactions with the SARS-CoV-2 Receptor Binding Domain. In Bradfute, S. B. (ed.), Recombinant Glycoproteins: Methods and Protocols (pp. 89-105). External link
Forest-Nault, C., Koyuturk, I., Gaudreault, J., Pelletier, A., L'Abbé, D., Cass, B., Bisson, L., Burlacu, A., Delafosse, L., Stuible, M., Henry, O., De Crescenzo, G., & Durocher, Y. (2022). Impact of the temperature on the interactions between common variants of the SARS-CoV-2 receptor binding domain and the human ACE2. Scientific Reports, 12(1), 11520 (11 pages). External link
Forest-Nault, C., Gaudreault, J., Henry, O., Durocher, Y., & De Crescenzo, G. (2021). On the use of surface plasmon resonance biosensing to understand IgG-FcγR interactions. International Journal of Molecular Sciences, 22(12), 6616 (27 pages). Available
Gaudreault, J., Forest‐Nault, C., Gilbert, M., Durocher, Y., Henry, O., & De Crescenzo, G. (2024). A low‐temperature SPR‐based assay for monoclonal antibody galactosylation and fucosylation assessment using FcγRIIA/B. Biotechnology and Bioengineering, 121(5), 1659-1673. Available
Gaudreault, J., Durocher, Y., Henry, O., & De Crescenzo, G. (2022). Multi-temperature experiments to ease analysis of heterogeneous binder solutions by surface plasmon resonance biosensing. Scientific Reports, 12(1), 14401 (25 pages). External link
Gaudreault, J., Liberelle, B., Durocher, Y., Henry, O., & De Crescenzo, G. (2021). Determination of the composition of heterogeneous binder solutions by surface plasmon resonance biosensing. Scientific Reports, 11(1), 3685 (16 pages). Available
Gaudreault, J., Forest-Nault, C., De Crescenzo, G., Durocher, Y., & Henry, O. (2021). On the Use of Surface Plasmon Resonance-Based Biosensors for Advanced Bioprocess Monitoring. Processes, 9(11), 1996 (28 pages). External link
Ghorbaniaghdam, A., Chen, J., Henry, O., & Jolicoeur, M. (2014). Analyzing Clonal Variation of Monoclonal Antibody-Producing CHO Cell Lines Using an In Silico Metabolomic Platform. PLOS One, 9(3). Available
Ghorbaniaghdam, A., Henry, O., & Jolicoeur, M. (2014). An in-silico study of the regulation of CHO cells glycolysis. Journal of Theoretical Biology, 357, 112-122. External link
Ghorbaniaghdam, A., Henry, O., & Jolicoeur, M. (2013). A kinetic-metabolic model based on cell energetic state: study of CHO cells behaviour under Na-butyrate stimulation. Bioprocess and Biosystems Engineering, 36(4), 469-487. External link
Ghorbaniaghdam, A., Henry, O., & Jolicoeur, M. (2010, July). A kinetic modelling approach to study the role of energy regulatory pathways in CHO cells [Paper]. 11th IFAC Symposium on Computer Applications in Biotechnology, Leuven, Belgium. Published in IFAC Proceedings Volumes, 43(6). External link
Henry, O., Karengera, E., Cambay, F., & De Crescenzo, G. (2020). Surface Plasmon Resonance-Based Method for Rapid Product Sialylation Assessment in Cell Culture. In Pörtner, R. (ed.), Animal Cell Biotechnology: Methods and Protocols (Vol. 2095, pp. 285-293). External link
Henry, O., & Durocher, Y. (2011). Enhanced glycoprotein production in HEK-293 cells expressing pyruvate carboxylase. Metabolic Engineering, 13(5), 499-507. External link
Henry, O., Jolicoeur, M., & Kamen, A. A. (2011). Unraveling the metabolism of HEK-293 cells using lactate isotopomer analysis. Bioprocess and Biosystems Engineering, 34(3), 263-73. External link
Henry, O., & Durocher, Y. (2010, July). Engineering of the Human Cell Line HEK-293 to Enhance Recombinant Protein Production [Paper]. 11th IFAC Symposium on Computer Applications in Biotechnology (CAB 2020), Leuven, Belgium. Published in IFAC Proceedings Volumes, 43(6). External link
Henry, O., Kwok, E., & Piret, J. M. (2008). Simpler Noninstrumented Batch and Semicontinuous Cultures Provide Mammalian Cell Kinetic Data Comparable to Continuous and Perfusion Cultures. Biotechnology Progress, 24(4), 921-931. External link
Henry, O., Kamen, A., & Perrier, M. (2006, April). Monitoring the Physiological State of Mammalian Cell Perfusion Processes by on-Line Estimation of Intracellular Fluxes [Paper]. ADCHEM 2006 Symposium, Gramado, Brazil. Published in Journal of Process Control, 17(3). External link
Henry, O., Ansorge, S., Aucoin, M., Voyer, R., & Kamen, A. (2007, June). On-line monitoring of cell size distribution in mammalian cell culture processes [Paper]. 10th IFAC Symposium on Computer Applications in Biotechnology, Cancun, Mexico. Published in IFAC Proceedings Volumes, 40(4). External link
Henry, O., Perrier, M., & Kamen, A. (2006, April). Monitoring the physiological state of mammalian cell perfusion processes by on-line estimation of intracellular fluxes [Paper]. International Symposium on Advanced Control of Chemical Processes, Gramado, Brazil. External link
Henry, O., Perrier, M., & Kamen, A. (2005). Metabolic Flux Analysis of Hek-293 Cells in Perfusion Cultures for the Production of Adenoviral Vectors. Metabolic Engineering, 7(5-6), 467-476. External link
Henry, O. (2004). Caractérisation et modélisation de la production de vecteurs adénoviraux dans un bioréacteur opérant en mode perfusion [Ph.D. thesis, École Polytechnique de Montréal]. Available
Henry, O., Dormond, E., Perrier, M., & Kamen, A. (2004). Insights into adenoviral vector production kinetics in acoustic filter-based perfusion cultures. Biotechnology and Bioengineering, 86(7), 765-774. External link
Henry, O., Perrier, M., & Kamen, A. (2004, March). On-line monitoring of adenovirus production in perfusion cultures [Paper]. 9th International Symposium on Computer Applications in Biotechnology (CAB9), Nancy, France. External link
Henry, O., Perrier, M., & Kamen, A. (2003, September). Optimization of adenovirus production in perfusion cultures using an ultrasonic retention device [Paper]. 6th Conference on Protein Expression in Animal Cells, Mont-Tremblant. Unavailable
Karengera, E., Robotham, A., Kelly, J., Durocher, Y., De Crescenzo, G., & Henry, O. (2018). Concomitant reduction of lactate and ammonia accumulation in fed-batch cultures: Impact on glycoprotein production and quality. Biotechnology Progress, 34(2), 494-504. External link
Karengera, E., Robotham, A., Kelly, J., Durocher, Y., De Crescenzo, G., & Henry, O. (2017). Altering the central carbon metabolism of HEK293 cells: Impact on recombinant glycoprotein quality. Journal of Biotechnology, 242, 73-82. External link
Karengera, E., Durocher, Y., De Crescenzo, G., & Henry, O. (2017). Combining metabolic and process engineering strategies to improve recombinant glycoprotein production and quality. Applied Microbiology and Biotechnology, 101(21), 7837-7851. External link
Karengera, E., De Crescenzo, G., Durocher, Y., & Henry, O. (2016, May). Improving the metabolic efficiency of mammalian cells and its impact on glycoproteins quality [Poster]. Cell Culture Engineering XV, Palm Spring (CA). Unavailable
Kamen, A., & Henry, O. (2004). Development and optimization of an adenovirus production process. Journal of Gene Medicine, 6(S1), S184-S192. External link
Kamen, A., Henry, O., Jacob, D., & Bernier, A. (2003, May). Successful development of a robust adenovirus production process primarily relies on a better understanding of packaging cell line physiology and vector replication kinetics [Paper]. 18th ESACT Meeting, Granada, Spain. External link
Lemire, L., Pham, P. L., Durocher, Y., & Henry, O. (2021). Practical Considerations for the Scale-Up of Chinese Hamster Ovary (CHO) Cell Cultures. In Cell Culture Engineering and Technology: In appreciation to Professor Mohamed Al-Rubeai (Vol. 10, pp. 367-400). External link
Le Ru, A., Jacob, D., Transfiguracion, J., Ansorge, S., Henry, O., & Kamen, A. A. (2010). Scalable Production of Influenza Virus in Hek-293 Cells for Efficient Vaccine Manufacturing. Vaccine, 28(21), 3661-3671. External link
Mellahi, K., Brochu, D., Gilbert, M., Perrier, M., Ansorge, S., Durocher, Y., & Henry, O. (2019). Assessment of fed-batch cultivation strategies for an inducible CHO cell line. Journal of Biotechnology, 298, 45-56. External link
Mellahi, K., Cambay, F., Brochu, D., Gilbert, M., Perrier, M., Ansorge, S., Durocher, Y., & Henry, O. (2019). Process development for an inducible rituximab-expressing Chinese hamster ovary cell line. Biotechnology Progress, 35(1), e2742. External link
Mellahi, K., Brochu, D., Gilbert, M., Perrier, M., Ansorge, S., Durocher, Y., & Henry, O. (2019). Process intensification for the production of rituximab by an inducible CHO cell line. Bioprocess and Biosystems Engineering, 42(5), 711-725. External link
Nadeau, I., Henry, O., Jacob, D., Perrier, M., & Kamen, A. (2001, June). Effect of Medium Composition on the 293SF Central Metabolic Fluxes during Growth and Infection with Adenovirus [Paper]. 8th International Symposium on Computer Applications in Biotechnology (CAB8), Québec City, Qc. Unavailable
Reyes, S.‐J., Lemire, L., Durocher, Y., Voyer, R., Henry, O., & Pham, P. L. (2025). Investigating the metabolic load of monoclonal antibody production conveyed to an inducible CHO cell line using a Transfer-Rate Online Monitoring system. Journal of Biotechnology, 36 pages. External link
Reyes, S.‐J., Pham, P. L., Durocher, Y., & Henry, O. (2024). CHO stable pool fed-batch process development of SARS-CoV-2 spike protein production: Impact of aeration conditionsand feeding strategies. Biotechnology Progress, 3507 (20 pages). Available
Reyes, S.‐J., Lemire, L., Roy, M., L'Écuyer-Coelho, H., Martynova, Y., Cass, B., Voyer, R., Durocher, Y., Henry, O., Pham, P. L., & Molina, R.-S. (2024). Multivariate data analysis of process parameters affecting the growth and productivity of stable Chinese hamster ovary cell pools expressing SARS‐CoV‐2 spike protein as vaccine antigen in early process development. Biotechnology Progress, e3467 (19 pages). Available
Reyes, S. J., Durocher, Y., Pham, P. L., & Henry, O. (2022). Modern Sensor Tools and Techniques for Monitoring, Controlling, and Improving Cell Culture Processes. Processes, 10(2), 189 (36 pages). External link
Riahi, N., Murschel, F., Lerouge, S., Durocher, Y., Henry, O., & De Crescenzo, G. (2017). Bioavailability of immobilized epidermal growth factor: Covalent versus noncovalent grafting. Biointerphases, 12(1), 010501 (8 pages). External link
Riahi, N., Liberelle, B., Henry, O., & De Crescenzo, G. (2017). Impact of RGD amount in dextran-based hydrogels for cell delivery. Carbohydrate Polymers, 161, 219-227. External link
Riahi, N., Cappadocia, L., Henry, O., Omichinski, J., & De Crescenzo, G. (2016). Soluble expression, purification and functional characterization of a coil peptide composed of a positively charged and hydrophobic motif. Amino Acids, 48(2), 567-577. External link
Serafin, B., Kamen, A., De Crescenzo, G., & Henry, O. (2025). Impact of Lectin Biotinylation for surface plasmon resonance and enzyme-linked Lectin assays for protein glycosylation. Analytical Biochemistry, 696, 115693 (9 pages). Available
Silva, C. A. T., Kamen, A., & Henry, O. (2024). Fed-batch strategies for intensified rVSV vector production in high cell density cultures of suspension HEK293 cells. Biotechnology Progress, 3506 (9 pages). Available
Serafin, B., Kamen, A., De Crescenzo, G., & Henry, O. (2024). Antibody-independent surface plasmon resonance assays for influenza vaccine quality control. Applied Microbiology and Biotechnology, 108(1), 307 (10 pages). Available
Silva, C. A. T., Kamen, A. A., & Henry, O. Intensified Influenza Virus Production in Suspension HEK293SF Cell Cultures Operated in Fed-Batch or Perfusion with Continuous Harvest [Paper]. Unspecified (19 pages). External link
Silva, C. A. T., Kamen, A. A., & Henry, O. (2022, June). Intensification of influenza virus production in fed-batch and perfusion cultures of HEK293SF cells [Paper]. Vaccine Technology VIII, Stiges, Spain. External link
Silva, C. A. T., Kamen, A. A., & Henry, O. (2021). Recent advances and current challenges in process intensification of cell culture-based influenza virus vaccine manufacturing. Canadian Journal of Chemical Engineering, 99(11), 2525-2535. External link
Sheikholeslami, Z., Jolicoeur, M., & Henry, O. (2014). Elucidating the effects of postinduction glutamine feeding on the growth and productivity of CHO cells. Biotechnology Progress, 30(3), 535-546. External link
Sheikholeslami, Z., Jolicoeur, M., & Henry, O. (2013). The impact of the timing of induction on the metabolism and productivity of CHO cells in culture. Biochemical Engineering Journal, 79, 162-171. External link
Sheikholeslami, Z., Jolicoeur, M., & Henry, O. (2013). Probing the metabolism of an inducible mammalian expression system using extracellular isotopomer analysis. Journal of Biotechnology, 164(4), 469-478. External link
Toussaint, C., Henry, O., & Durocher, Y. (2016). Metabolic engineering of CHO cells to alter lactate metabolism during fed-batch cultures. Journal of Biotechnology, 217(C), 122-131. Available
Thompson, C. M., Petiot, E., Mullick, A., Aucoin, M. G., Henry, O., & Kamen, A. A. (2015). Critical assessment of influenza VLP production in Sf9 and HEK293 expression systems. BMC Biotechnology, 15(1). Available
Thompson, C. M., Petiot, E., Aucoin, M. G., Henry, O., & Kamen, A. A. (2013, June). Developing a production process for influenza VLPs: a comparison between HEK 293SF and Sf9 production platforms [Poster]. 23rd European Society for Animal Cell Technology Meeting (ESACT 2013), Lille, France (2 pages). Published in BMC Proceedings, 7(S6). Available
Thompson, C. M., Petiot, E., Lennaertz, A., Henry, O., & Kamen, A. A. (2013). Analytical technologies for influenza virus-like particle candidate vaccines: challenges and emerging approaches. Virology Journal, 10(1). Available
Venereo-Sanchez, A., Fulton, K., Koczka, K., Twine, S., Chahal, P., Ansorge, S., Gilbert, R., Henry, O., & Kamen, A. (2019). Characterization of influenza H1N1 Gag virus-like particles and extracellular vesicles co-produced in HEK-293SF. Vaccine, 37(47), 7100-7107. External link
Venereo-Sanchez, A., Simoneau, M., Lanthier, S., Chahal, P., Bourget, L., Ansorge, S., Gilbert, R., Henry, O., & Kamen, A. (2017). Process intensification for high yield production of influenza H1N1 Gag virus-like particles using an inducible HEK-293 stable cell line. Vaccine, 35(33), 4220-4228. External link
Venereo-Sanchez, A., Gilbert, R., Simoneau, M., Caron, A., Chahal, P., Chen, W., Ansorge, S., Li, X., Henry, O., & Kamen, A. (2016). Hemagglutinin and neuraminidase containing virus-like particles produced in HEK-293 suspension culture: An effective influenza vaccine candidate. Vaccine, 34(29), 3371-3380. External link
Vallee, C., Durocher, Y., & Henry, O. (2014). Exploiting the metabolism of PYC expressing HEK293 cells in fed-batch cultures. Journal of Biotechnology, 169(1), 63-70. External link
Yang, Z., Xu, X., Silva, C. A. T., Farnos, O., Venereo-Sanchez, A., Toussaint, C., Dash, S., Gonzalez-Dominguez, I., Bernier, A., Henry, O., & Kamen, A. (2022). Membrane chromatography-based downstream processing for cell-culture produced influenza vaccines. Vaccines, 10(8), 1310 (13 pages). External link
