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Marc LavertuDepartment of Chemical Engineering
Profile in the Directory of Experts of Polytechnique Montréal
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Alameh, M.‐G., Naeini, A. T., Dwivedi, G., Lesage, F., Buschmann, M. D., & Lavertu, M. (2024). Chitosan siRNA nanoparticles produce significant non-toxic functional gene silencing in Kidney Cortices. Polymers, 16(17), 2547 (22 pages). Available
Alameh, M.-G., Semon, A., Bayard, N. U., Pan, Y.-G., Dwivedi, G., Knox, J., Glover, R. C., Rangel, P. C., Tanes, C., Bittinger, K., She, Q., Hu, H., Bonam, S. R., Maslanka, J. R., Planet, P. J., Moustafa, A. M., Davis, B., Chevrier, A., Beattie, M., ... Zackular, J. P. (2024). A multivalent mRNA-LNP vaccine protects against Clostridioides difficile infection. Science, 386(6717), 69-75. External link
Ahunon, L., Milano, F., Chevrier, A., & Lavertu, M. (2020). A novel image analysis algorithm reveals that media conditioned with chitosan and platelet-rich plasma biomaterial dose dependently increases fibroblast migration in a scratch assay. Biomedical Physics & Engineering Express, 6(6), 15 pages. External link
Alameh, M., Lavertu, M., Tran-Khanh, N., Chang, C.-Y., Lesage, F., Bail, M., Darras, V., Chevrier, A., & Buschmann, M. D. (2018). siRNA delivery with chitosan: influence of chitosan molecular weight, degree of deacetylation, and amine to phosphate ratio on in vitro silencing efficiency, hemocompatibility, biodistribution, and in vivo efficacy. Biomacromolecules, 19(1), 112-131. External link
Alameh, M.-G., Lavertu, M., Merzouki, A., Biniecki, K., & Buschmann, M. D. (2014, May). Chitosan/siRNA nanoparticles demonstrate superior silencing efficiency and lower toxicity compared to lipid nanoparticles [Abstract]. 17th Annual Meeting of the American Society of Gene & Cell Therapy, Washington, DC. Published in Molecular Therapy, 22(S1). Available
BenDavid, E., Ramezanian, S., Lu, Y., Rousseau, J., Schroeder, A., Lavertu, M., & Tremblay, J. P. (2024). Emerging perspectives on prime editor delivery to the brain. Pharmaceuticals, 17(6), 763 (42 pages). Available
Buschmann, M. D., Lavertu, M., Nelea, M., Darras, V., Alameh, M. G., Chevrier, A., Tran-Khanh, N., Naeini Tavakoli, A., & Veilleux, D. (2018). Coated chitosan-based polyplex for delivery of nucleic acids. (Patent Application no. US20180028458). External link
Buschmann, M. D., Lavertu, M., & Veilleux, D. (2016). Freeze-dried polyelectrolyte complexes that maintain size and biological activity. (Patent Application no. US20160130606). External link
Buschmann, M. D., Merzouki, A., Lavertu, M., Thibault, M., Jean, M., & Darras, V. (2013). Chitosans for delivery of nucleic acids. Advanced Drug Delivery Reviews, 65(9), 1234-1270. External link
Buschmann, M. D., Thibault, M., Merzouki, A., Lavertu, M., Ma, P. L., Jean, M., Darras, V., & Winnik, F. M. (2010, May). Polynucleotide delivery with chitosans [Paper]. 93rd Canadian Chemistry Conference, Toronto, Ontario. Unavailable
Buschmann, M. D., Thibault, M., Merzouki, A., & Lavertu, M. (2009, August). Polynucleotide delivery with chitosans [Paper]. 8th World Congress of Chemical Engineering, Montréal, Québec. Unavailable
Buschmann, M. D., Garon, M., Ouellet, M., & Lavertu, M. (2001). Universal mechanical testing device. (Patent no. US6332364). External link
Chevrier, A., & Lavertu, M. (2024). Manufacturing process affects coagulation kinetics of Ortho-R, an injectable chitosan–platelet-rich plasma biomaterial for tissue repair. Bioengineering, 11(9), 929 (10 pages). Available
Chevrier, A., Hurtig, M. B., & Lavertu, M. (2022). Chitosan-platelet-rich plasma implants improve rotator cuff repair in a large animal model: Pilot study. Journal of Biomaterials Applications, 37(2), 183-194. External link
Chevrier, A., Hurtig, M. B., & Lavertu, M. (2021). Chitosan-Platelet-Rich Plasma Implants Improve Rotator Cuff Repair in a Large Animal Model: Pivotal Study. Pharmaceutics, 13(11), 1955 (16 pages). External link
Chevrier, A., Darras, V., Picard, G., Nelea, M., Veilleux, D., Lavertu, M., Hoemann, C. D., & Buschmann, M. D. (2018). Injectable chitosan-platelet-rich plasma (PRP) implants to promote tissue regeneration: In vitro properties, in vivo residence, degradation, cell recruitment and vascularization. Journal of Tissue Engineering and Regenerative Medicine, 12(1), 217-228. External link
Chevrier, A., Buschmann, M. D., Veilleux, D., Hoemann, C. D., & Lavertu, M. (2017). Freeze-dried polymer compositions for mixing with platelet rich plasma to form implants for tissue repair and/or compositions for therapeutic intra-articular injections. (Patent Application no. US20170049696). External link
Chattopadhyahya, B., Sanon, N. T., Dominique, D. B., Lavertu, M., Berryer, M., Desgent, S., Salam, T., Carmant, L., & Dicristo, G. (2013, June). Hypoxia-Induced Seizures Affect Interneuronal Network Maturation in the Mouse Hippocampus and Neocortex [Paper]. 30th International Epilepsy Congress, Montréal, Canada. Published in Epilepsia, 54(S3). External link
Esquivel Guzmán, J. A., Zhang, H., Mohanty, C., Liu, X., Rivera, E., Illescas, J., Lavertu, M., & Zhu, X. X. (2022). Thermoresponsive copolymers based on synthetic porphyrin derivatives. MRS Advances, 7(34), 1126-1132. External link
Esquivel Guzmán, J. A., Zhang, H., Rivera, E., Lavertu, M., & Zhu, X.-X. (2021). Porphyrin-Based Polyesters Synthesized by Enzymatic Catalysis. ACS Applied Polymer Materials, 3(7), 3659-3665. External link
Fong, D., Gregoire-Gelinas, P., Cheng, A. P., Mezheritsky, T., Lavertu, M., Sato, S., & Hoemann, C. D. (2017). Lysosomal rupture induced by structurally distinct chitosans either promotes a type 1 IFN response or activates the inflammasome in macrophages. Biomaterials, 129, 127-138. Available
Fong, D., Gregoire-Gelinas, P., Lavertu, M., Sato, S., & Hoemann, C. D. (2016, May). Human macrophages release higher IL-1ra over IL-1beta when stimulated by block acetylated chitosan microparticles and not by random acetylated chitosans or water-soluble oligomers [Poster]. 10th World Biomaterials Congress, Montréal, Québec. Published in Frontiers in Bioengineering and Biotechnology, 4. Available
Filion, D., Lavertu, M., & Buschmann, M. D. (2007). Ionization and Solubility of Chitosan Solutions Related to Thermosensitive Chitosan/Glycerol-Phosphate Systems. Biomacromolecules, 8(10), 3224-3234. External link
Filion, D., Lavertu, M., & Buschmann, M. D. (2004, June). Ionization-state dependent behavior of chitosan solutions : Theory and experiments [Paper]. Transactions Polyelectrolytes, Amherst, Massachusetts, USA. Unavailable
Ghattas, M., Dwivedi, G., Chevrier, A., Horn-Bourque, D., Alameh, M.-G., & Lavertu, M. (2025). Chitosan immunomodulation: insights into mechanisms of action on immune cells and signaling pathways. RSC Advances, 15(2), 896-909. External link
Ghattas, M., Dwivedi, G., Lavertu, M., & Alameh, M.-G. (2021). Vaccine Technologies and Platforms for Infectious Diseases: Current Progress, Challenges, and Opportunities. Vaccines, 9(12), 1490 (31 pages). External link
Ghazi Zadeh, L., Chevrier, A., Lamontagne, M., Buschmann, M. D., Hoemann, C. D., & Lavertu, M. (2019). Multiple platelet-rich plasma preparations can solubilize freeze-dried chitosan formulations to form injectable implants for orthopedic indications. Bio-Medical Materials and Engineering, 30(4), 349-364. External link
Han, X., Alameh, M.-G., Butowska, K., Knox, J. J., Lundgreen, K., Ghattas, M., Gong, N., Xue, L., Xu, Y., Lavertu, M., Bates, P., Xu, J., Nie, G., Zhong, Y., Weissman, D., & Mitchell, M. J. (2023). Adjuvant lipidoid-substituted lipid nanoparticles augment the immunogenicity of SARS-CoV-2 mRNA vaccines. Nature Nanotechnology, 18(9), 1105-1114. External link
Hoemann, C. D., Guzmán-Morales, J., Tran-Khanh, N., Lavallée, G., Jolicoeur, M., & Lavertu, M. (2013). Chitosan rate of uptake in HEK293 cells is influenced by soluble versus microparticle state and enhanced by serum-induced cell metabolism and lactate-based media acidification. Molecules, 18(1), 1015-1035. Available
Hoemann, C. D., Ma, O., Lavertu, M., Lavalée, G., Sun, J., El-Gabalawy, H., Tran-Khanh, N., & Winnik, F. (2006, May). Controlled derivatization of chitosan with rhodamine B-isothiocyanate to study the influence of chitosan structure on stromal cell recognition and uptake [Paper]. Can Workshop on Pre-Clinical OA models, Montréal, Québec. Unavailable
Jeandupeux, E., Alameh, M.-G., Ghattas, M., De Crescenzo, G., & Lavertu, M. (2021). Poly(2-Propylacrylic Acid) Increases In Vitro Bioactivity of Chitosan/mRNA Nanoparticles. Journal of Pharmaceutical Sciences, 110(10), 3439-3449. External link
Jean, M., Alameh, M., De Jesus, D., Thibault, M., Lavertu, M., Darras, V., Nelea, M., Buschmann, M. D., & Merzouki, A. (2012). Chitosan-Based Therapeutic Nanoparticles for Combination Gene Therapy and Gene Silencing of in Vitro Cell Lines Relevant to Type 2 Diabetes. European Journal of Pharmaceutical Sciences, 45(1-2), 138-149. External link
Jean, M., Alameh, M., Daras, V., Lavertu, M., Thibault, M., Buschmann, M. D., & Merzouki, A. (2011, May). Effective and safe gene-based delivery of GLP-1 using chitosan/plasmid-DNA therapeutic nanocomplexes in an animal model of Type 2 Diabetes [Paper]. 14th Annual Meeting American Society of Gene and Cell Therapy, Seattle, WA, USA. Unavailable
Jean, M., Alameh, M., Daras, V., Lavertu, M., Thibault, M., Buschmann, M. D., & Merzouki, A. (2011, May). Effective and safe gene-based delivery of GLP-1 using chitosan/plasmid-DNA therapeutic nanocomplexes in an animal model of Type 2 Diabetes [Paper]. 1st Meeting of Canadian Chapter of The Controlled Release Society, Montréal, Québec, Canada. Unavailable
Jean, M., Smaoui, F., Lavertu, M., Methot, S., Bouhdoud, L., Buschmann, M. D., & Merzouki, A. (2009). Chitosan-Plasmid Nanoparticle Formulations for Im and Sc Delivery of Recombinant Fgf-2 and Pdgf-Bb or Generation of Antibodies. Gene Therapy, 16(9), 1097-1110. External link
Liu, X., Beaudoin, G., Zhang, H., Esquivel Guzmán, J. A., Le Roux, É., Pellerin, C., Rivera, E., Lavertu, M., & Zhu, X. X. (2023). Chlorophyllin-Containing Copolymers and Their Responsive Properties. ACS Applied Bio Materials, 7 pages. External link
Lavertu, M., Darras, V., & Buschmann, M. D. (2012). Kinetics and efficiency of chitosan reacetylation. Carbohydrate Polymers, 87(2), 1192-1198. External link
Lavertu, M., Filion, D., & Buschmann, M. D. (2008). Heat-Induced Transfer of Protons From Chitosan to Glycerol Phosphate Produces Chitosan Precipitation and Gelation. Biomacromolecules, 9(2), 640-650. External link
Lavertu, M. (2007). Caractérisation du système thermosensible chitosane-glycérol phosphate et applications pour la livraison de gènes [Ph.D. thesis, École Polytechnique de Montréal]. Available
Lavertu, M., Méthot, S., Tran-Khanh, N., & Buschmann, M. D. (2006). High Efficiency Gene Transfer Using Chitosan/DNA Nanoparticles With Specific Combinations of Molecular Weight and Degree of Deacetylation. Biomaterials, 27(27), 4815-4824. External link
Lavertu, M., Filion, D., Schmid, A., Zayani, M., & Buschmann, M. D. (2006, September). Studies on the mechanism of thermal gelation of chitosan-glycerol phosphate solutions [Paper]. Transactions 10th International Conference on Chitin and Chitosan, Montpellier, France. Unavailable
Lavertu, M., Filion, D., Schmid, A., Zayani, M., & Buschmann, M. D. (2006, October). Studies on the mechanism of thermal gelation of chitosan-glycerol phosphate solutions [Paper]. Transactions 56th Canadian Chemical Engineering Conference, Sherbrooke, Québec, Canada. Unavailable
Lavertu, M., Methot, S., & Buschmann, M. D. (2004, June). Nanoparticules polymeres-ADN pour le transfert de gène [Paper]. Nanobiointerfaces pour les dispositifs intelligents, 17ième Entretiens du Centre Jacques Cartier, Montréal, Québec. Unavailable
Lavertu, M., Xia, Z., Serreqi, A. N., Berrada, M., Rodrigues, A., Wang, D., Buschmann, M. D., & Gupta, A. (2003). A validated ¹H NMR method for the determination of the degree of deacetylation of chitosan. Journal of pharmaceutical and biomedical analysis, 32(6), 1149-1158. External link
Milano, F., Chevrier, A., De Crescenzo, G., & Lavertu, M. (2023). Injectable Lyophilized Chitosan-Thrombin-Platelet-Rich Plasma (CS-FIIa-PRP) Implant to Promote Tissue Regeneration: In Vitro and Ex Vivo Solidification Properties. Polymers, 15(13), 2919 (15 pages). Available
Milano, F., Chevrier, A., De Crescenzo, G., & Lavertu, M. (2021). Robust Segmentation-Free Algorithm for Homogeneity Quantification in Images. IEEE Transactions on Image Processing, 30, 5533-5544. External link
Ma, P. L., Lavertu, M., Winnik, F. M., & Buschmann, M. D. (2017). Stability and binding affinity of DNA/chitosan complexes by polyanion competition. Carbohydrate Polymers, 176, 167-176. External link
Merzouki, A., Alameh, M., DeJesus, D., Jean, M., Darras, V., Thibault, M., Lavertu, M., & Buschmann, M. D. (2012). Low molecular weight chitosan nanoparticulate system at low N:P ratio for nontoxic polynucleotide delivery. International Journal of Nanomedicine, 7, 1399-1414. Available
Ma, O., Lavertu, M., Sun, J., Nguyen, S., Buschmann, M. D., Winnik, F. M., & Hoemann, C. D. (2008). Precise Derivatization of Structurally Distinct Chitosans With Rhodamine B Isothiocyanate. Carbohydrate polymer, 72(4), 616-624. External link
Méthot, S., Lavertu, M., Sun, J., Smaoui, F., Jean, M., Merzouki, A., & Buschmann, M. D. (2007, September). Efficient in vivo gene delivery using chitosan/DNA nanoparticles for applications in cartilage repair [Paper]. 7th World Congress International Society for Cartilage Repair, Warsaw, Poland. External link
Méthot, S., Lavertu, M., Ma, P. L., Winnik, F., & Buschmann, M. D. (2006, September). High Efficiency Gene Transfer Using Chitosan/DNA Nanoparticles With Specific Combinations of Molecular Weight and Degree of Deacetylation [Paper]. Transactions 10th International Conference on Chitin and Chitosan, Montpellier, France. Unavailable
Naeini, A. T., Alameh, M.-G., Soliman, O. Y., & Lavertu, M. (2022). Purification and Surface Modification of Chitosan-based Polyplexes Using Tangential Flow Filtration and Coating by Hyaluronic Acid. Journal of Pharmaceutical Sciences, 111(10), 2857-2866. External link
Niebel, Y., Buschmann, M. D., Lavertu, M., & De Crescenzo, G. (2014). Combined Analysis of Polycation/ODN Polyplexes by Analytical Ultracentrifugation and Dynamic Light Scattering Reveals their Size, Refractive Index Increment, Stoichiometry, Porosity, and Molecular Weight. Biomacromolecules, 15(3), 940-947. External link
Nimesh, S., Thibault, M., Lavertu, M., & Buschmann, M. D. (2010). Enhanced gene delivery mediated by low molecular weight chitosan/DNA complexes: effect of pH and serum. Molecular Biotechnology, 46(2), 182-96. Available
Nelea, M., Lavertu, M., Ma, P. L., & Buschmann, M. D. (2008, May). Imaging of chitosan-plasmid DNA nanoparticles by scanning electron microscopy and atomic force microscopy [Paper]. Microscopical Society of Canada Meeting, Montréal, Québec. Unavailable
Ouyang, W., Buschmann, M. D., Hoemann, C. D., Lavertu, M., & Chevrier, A. (2017). Novel formulation of physiological chitosan-inorganic salt solution/blood mixtures for tissue repair. (Patent Application no. US20170333477). External link
Pickenhahn, V., Grange, M., De Crescenzo, G., Lavertu, M., & Buschmann, M. D. (2017). Regioselective chitosan end-group activation: the triskelion approach. RSC Advances, 7(30), 18628-18638. Available
Pickenhahn, V. D., Lavertu, M., Buschmann, M. D., De Crescenzo, G., & Darras, V. (2016). Conjugated chitosans and method of use and of making same. (Patent Application no. WO2016101068). External link
Pickenhahn, V., Darras, V., Dziopa, F., Biniecki, K., De Crescenzo, G., Lavertu, M., & Buschmann, M. D. (2015). Regioselective thioacetylation of chitosan end-groups for nanoparticle gene delivery systems. Chemical Science, 6(8), 4650. Available
Pei, L. M., Lavertu, M., Winnik, F. M., & Buschmann, M. D. (2009). New insights into chitosan-DNA interactions using isothermal titration microcalorimetry. Biomacromolecules, 10(6), 1490-1499. External link
Richard, I., Thibault, M., De Crescenzo, G., Buschmann, M. D., & Lavertu, M. (2013). Ionization behavior of chitosan and chitosan-DNA polyplexes indicate that chitosan has a similar capability to induce a proton-sponge effect as PEI. Biomacromolecules, 14(6), 1732-1740. External link
Soliman, O. Y., Alameh, M. G., De Crescenzo, G., Buschmann, M. D., & Lavertu, M. (2020). Efficiency of Chitosan/Hyaluronan-Based mRNA Delivery Systems In Vitro: Influence of Composition and Structure. Journal of Pharmaceutical Sciences, 109(4), 1581-1593. External link
Tavakoli Naeini, A., Soliman, O. Y., Alameh, M. G., Lavertu, M., & Buschmann, M. D. (2017). Automated in-line mixing system for large scale production of chitosan-based polyplexes. Journal of Colloid and Interface Science, 500, 253-263. External link
Thibault, M., Lavertu, M., Astolfi, M., & Buschmann, M. D. (2016). Structure Dependence of Lysosomal Transit of Chitosan-Based Polyplexes for Gene Delivery. Molecular Biotechnology, 58(10), 648-656. External link
Tavakoli Naeini, A., Lavertu, M., Buschmann, M. D., & Biniecki, K. (2014, May). Large scale preparation of chitosan/nucleic acid nanoparticles using an automated inline mixing system [Abstract]. American Society of Gene & Cell Therapy 17th Annual Meeting, Washington, DC. Published in Molecular Therapy, 22. Available
Thibault, M., Astolfi, M., Tran-Khanh, N., Lavertu, M., Darras, V., Merzouki, A., & Buschmann, M. D. (2011, May). Excess polycation mediates efficient chitosan-based gene transfer by promoting lysosomal release of the polyplexes [Paper]. 1st Meeting of Canadian Chapter of The Controlled Release Society, Montréal, Québec. Unavailable
Thibault, M., Astolfi, M., Tran-Khanh, N., Lavertu, M., Darras, V., Merzouki, A., & Buschmann, M. D. (2011). Excess polycation mediates efficient chitosan-based gene transfer by promoting lysosomal release of the polyplexes. Biomaterials, 32(20), 4639-4646. External link
Thibault, M., Astolfi, M., Lavertu, M., Darras, M., & Buschmann, M. D. (2011, May). The role and fate of excess polycations in efficient chitosan-based gene transfection [Paper]. 14th Annual Meeting American Society of Gene and Cell Therapy, Seattle, WA. Unavailable
Thibault, M., Nimesh, S., Lavertu, M., & Buschmann, M. D. (2010). Intracellular Trafficking and Decondensation Kinetics of Chitosan–pDNA Polyplexes. Molecular Therapy, 18(10), 1787-1795. Available
Thibault, M., Nimesh, S., Lavertu, M., & Buschmann, M. D. (2010, May). Intracellular trafficking and decondensation kinetics of chitosan-pDNA Polyplexes [Paper]. 13th Annual Meeting of American Society of Gene and Cell Therapy, Washington, DC. Unavailable
Thibault, M., Nimesh, S., Janta-Polanski, M., Lavertu, M., & Buschmann, M. D. (2008, October). Intercellular trafficking and dissociation kinetics of specific chitosan-pDNA polyplexes [Paper]. 6th International Nanomedicine and Drug Delivery Symposium, Toronto, ON, Canada. Unavailable
Tran-Khanh, N., Lavertu, M., Hoemann, C. D., & Buschmann, M. D. (2007, February). Chondrocyte proliferation at the agarose-media interface resembles appositional mechanisms of the epiphyseal growth plate [Paper]. 53rd Annual Meeting of the Orthopaedic Research Society, San Diego, CA, USA. External link
Tran-Khanh, N., Lavertu, M., Lascau-Coman, V., Hoemann, C. D., & Buschmann, M. D. (2007, September). Time-lapse confocal imaging of living chondrocytes in appositionally developing outgrowths at the agarose-media interface [Paper]. 7th World Congress International Society for Cartilage Repair, Warsaw, Poland. External link
Tran-Khanh, N., Lavertu, M., Hoemann, C. D., & Buschmann, M. D. (2006, October). Chondrocyte proliferation at the agarose-media interface resembles appositional mechanisms of the epiphyseal growth plate [Paper]. Transactions 56th Canadian Chemical Engineering Conference, Sherbrooke, QC. Unavailable
Veilleux, D., Gopalakrishna Panicker, R. K., Chevrier, A., Biniecki, K., Lavertu, M., & Buschmann, M. D. (2018). Lyophilisation and concentration of chitosan/siRNA polyplexes: Influence of buffer composition, oligonucleotide sequence, and hyaluronic acid coating. Journal of Colloid and Interface Science, 512, 335-345. External link
Veilleux, D., Nelea, M., Biniecki, K., Lavertu, M., & Buschmann, M. D. (2016). Preparation of Concentrated Chitosan/DNA Nanoparticle Formulations by Lyophilization for Gene Delivery at Clinically Relevant Dosages. Journal of Pharmaceutical Sciences, 105(1), 88-96. External link
Veilleux, D., Lavertu, M., Biniecki, K., & Buschmann, M. D. (2014, May). Lyophilized chitosan nanoparticles for pDNA and siRNA delivery: Physico-chemical properties, transfection efficiency, and cytotoxicity [Abstract]. American Society of Gene & Cell Therapy 17th Annual Meeting, Washington, DC. Published in Molecular Therapy, 22(S1). Available
Zhang, H., Esquivel Guzman, J. A., Feng, X., Rivera, E., Lavertu, M., & Zhu, X. X. (2020). Protoporphyrin IX copolymer with poly(Ethylene glycol) methacrylate and its thermoresponsive properties. Canadian Journal of Chemistry, 98(9), 511-515. External link
