Eli BenDavid, Sina Ramezanian, Yaoyao Lu, Joël Rousseau, Avi Schroeder, Marc Lavertu
and Jacques P. Tremblay
Article (2024)
 Open Acess document in PolyPublie and at official publisher |
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Open Access to the full text of this document Published Version Terms of Use: Creative Commons Attribution Download (5MB) |
Abstract
Prime editing shows potential as a precision genome editing technology, as well as the potential to advance the development of next-generation nanomedicine for addressing neurological disorders. However, turning in prime editors (PEs), which are macromolecular complexes composed of CRISPR/Cas9 nickase fused with a reverse transcriptase and a prime editing guide RNA (pegRNA), to the brain remains a considerable challenge due to physiological obstacles, including the blood–brain barrier (BBB). This review article offers an up-to-date overview and perspective on the latest technologies and strategies for the precision delivery of PEs to the brain and passage through blood barriers. Furthermore, it delves into the scientific significance and possible therapeutic applications of prime editing in conditions related to neurological diseases. It is targeted at clinicians and clinical researchers working on advancing precision nanomedicine for neuropathologies.
Uncontrolled Keywords
| Additional Information: | Groupe de recherche: Laboratory of Biomaterials and Tissue Engineering |
|---|---|
| Subjects: |
1800 Chemical engineering > 1800 Chemical engineering 1900 Biomedical engineering > 1900 Biomedical engineering 1900 Biomedical engineering > 1901 Biomedical technology |
| Department: |
Department of Mechanical Engineering Institut de génie biomédical |
| Research Center: | Other |
| Funders: | Canadian Institute of Heath Research |
| Grant number: | 185747 |
| PolyPublie URL: | https://publications.polymtl.ca/58613/ |
| Journal Title: | Pharmaceuticals (vol. 17, no. 6) |
| Publisher: | MDPI |
| DOI: | 10.3390/ph17060763 |
| Official URL: | https://doi.org/10.3390/ph17060763 |
| Date Deposited: | 26 Jun 2024 12:51 |
| Last Modified: | 26 Sep 2024 12:51 |
| Cite in APA 7: | BenDavid, E., Ramezanian, S., Lu, Y., Rousseau, J., Schroeder, A., Lavertu, M., & Tremblay, J. P. (2024). Emerging perspectives on prime editor delivery to the brain. Pharmaceuticals, 17(6), 763 (42 pages). https://doi.org/10.3390/ph17060763 |
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