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Marc LavertuDépartement de génie chimique
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Alameh, M.‐G., Naeini, A. T., Dwivedi, G., Lesage, F., Buschmann, M. D., & Lavertu, M. (2024). Chitosan siRNA nanoparticles produce significant non-toxic functional gene silencing in Kidney Cortices. Polymers, 16(17), 2547 (22 pages). Disponible
Chevrier, A., & Lavertu, M. (2024). Manufacturing process affects coagulation kinetics of Ortho-R, an injectable chitosan–platelet-rich plasma biomaterial for tissue repair. Bioengineering, 11(9), 929 (10 pages). Disponible
BenDavid, E., Ramezanian, S., Lu, Y., Rousseau, J., Schroeder, A., Lavertu, M., & Tremblay, J. P. (2024). Emerging perspectives on prime editor delivery to the brain. Pharmaceuticals, 17(6), 763 (42 pages). Disponible
Alameh, M.-G., Semon, A., Bayard, N. U., Pan, Y.-G., Dwivedi, G., Knox, J., Glover, R. C., Rangel, P. C., Tanes, C., Bittinger, K., She, Q., Hu, H., Bonam, S. R., Maslanka, J. R., Planet, P. J., Moustafa, A. M., Davis, B., Chevrier, A., Beattie, M., ... Zackular, J. P. (2024). A multivalent mRNA-LNP vaccine protects against Clostridioides difficile infection. Science, 386(6717), 69-75. Lien externe
Milano, F., Chevrier, A., De Crescenzo, G., & Lavertu, M. (2023). Injectable Lyophilized Chitosan-Thrombin-Platelet-Rich Plasma (CS-FIIa-PRP) Implant to Promote Tissue Regeneration: In Vitro and Ex Vivo Solidification Properties. Polymers, 15(13), 2919 (15 pages). Disponible
Han, X., Alameh, M.-G., Butowska, K., Knox, J. J., Lundgreen, K., Ghattas, M., Gong, N., Xue, L., Xu, Y., Lavertu, M., Bates, P., Xu, J., Nie, G., Zhong, Y., Weissman, D., & Mitchell, M. J. (2023). Adjuvant lipidoid-substituted lipid nanoparticles augment the immunogenicity of SARS-CoV-2 mRNA vaccines. Nature Nanotechnology, 18(9), 1105-1114. Lien externe
Liu, X., Beaudoin, G., Zhang, H., Esquivel Guzmán, J. A., Le Roux, É., Pellerin, C., Rivera, E., Lavertu, M., & Zhu, X. X. (2023). Chlorophyllin-Containing Copolymers and Their Responsive Properties. ACS Applied Bio Materials, 7 pages. Lien externe
Chevrier, A., Hurtig, M. B., & Lavertu, M. (2022). Chitosan-platelet-rich plasma implants improve rotator cuff repair in a large animal model: Pilot study. Journal of Biomaterials Applications, 37(2), 183-194. Lien externe
Naeini, A. T., Alameh, M.-G., Soliman, O. Y., & Lavertu, M. (2022). Purification and Surface Modification of Chitosan-based Polyplexes Using Tangential Flow Filtration and Coating by Hyaluronic Acid. Journal of Pharmaceutical Sciences, 111(10), 2857-2866. Lien externe
Esquivel Guzmán, J. A., Zhang, H., Mohanty, C., Liu, X., Rivera, E., Illescas, J., Lavertu, M., & Zhu, X. X. (2022). Thermoresponsive copolymers based on synthetic porphyrin derivatives. MRS Advances, 7(34), 1126-1132. Lien externe
Chevrier, A., Hurtig, M. B., & Lavertu, M. (2021). Chitosan-Platelet-Rich Plasma Implants Improve Rotator Cuff Repair in a Large Animal Model: Pivotal Study. Pharmaceutics, 13(11), 1955 (16 pages). Lien externe
Jeandupeux, E., Alameh, M.-G., Ghattas, M., De Crescenzo, G., & Lavertu, M. (2021). Poly(2-Propylacrylic Acid) Increases In Vitro Bioactivity of Chitosan/mRNA Nanoparticles. Journal of Pharmaceutical Sciences, 110(10), 3439-3449. Lien externe
Esquivel Guzmán, J. A., Zhang, H., Rivera, E., Lavertu, M., & Zhu, X.-X. (2021). Porphyrin-Based Polyesters Synthesized by Enzymatic Catalysis. ACS Applied Polymer Materials, 3(7), 3659-3665. Lien externe
Milano, F., Chevrier, A., De Crescenzo, G., & Lavertu, M. (2021). Robust Segmentation-Free Algorithm for Homogeneity Quantification in Images. IEEE Transactions on Image Processing, 30, 5533-5544. Lien externe
Ghattas, M., Dwivedi, G., Lavertu, M., & Alameh, M.-G. (2021). Vaccine Technologies and Platforms for Infectious Diseases: Current Progress, Challenges, and Opportunities. Vaccines, 9(12), 1490 (31 pages). Lien externe
Soliman, O. Y., Alameh, M. G., De Crescenzo, G., Buschmann, M. D., & Lavertu, M. (2020). Efficiency of Chitosan/Hyaluronan-Based mRNA Delivery Systems In Vitro: Influence of Composition and Structure. Journal of Pharmaceutical Sciences, 109(4), 1581-1593. Lien externe
Ahunon, L., Milano, F., Chevrier, A., & Lavertu, M. (2020). A novel image analysis algorithm reveals that media conditioned with chitosan and platelet-rich plasma biomaterial dose dependently increases fibroblast migration in a scratch assay. Biomedical Physics & Engineering Express, 6(6), 15 pages. Lien externe
Zhang, H., Esquivel Guzman, J. A., Feng, X., Rivera, E., Lavertu, M., & Zhu, X. X. (2020). Protoporphyrin IX copolymer with poly(Ethylene glycol) methacrylate and its thermoresponsive properties. Canadian Journal of Chemistry, 98(9), 511-515. Lien externe
Ghazi Zadeh, L., Chevrier, A., Lamontagne, M., Buschmann, M. D., Hoemann, C. D., & Lavertu, M. (2019). Multiple platelet-rich plasma preparations can solubilize freeze-dried chitosan formulations to form injectable implants for orthopedic indications. Bio-Medical Materials and Engineering, 30(4), 349-364. Lien externe
Buschmann, M. D., Lavertu, M., Nelea, M., Darras, V., Alameh, M. G., Chevrier, A., Tran-Khanh, N., Naeini Tavakoli, A., & Veilleux, D. (2018). Coated chitosan-based polyplex for delivery of nucleic acids. (Demande de brevet no US20180028458). Lien externe
Chevrier, A., Darras, V., Picard, G., Nelea, M., Veilleux, D., Lavertu, M., Hoemann, C. D., & Buschmann, M. D. (2018). Injectable chitosan-platelet-rich plasma (PRP) implants to promote tissue regeneration: In vitro properties, in vivo residence, degradation, cell recruitment and vascularization. Journal of Tissue Engineering and Regenerative Medicine, 12(1), 217-228. Lien externe
Veilleux, D., Gopalakrishna Panicker, R. K., Chevrier, A., Biniecki, K., Lavertu, M., & Buschmann, M. D. (2018). Lyophilisation and concentration of chitosan/siRNA polyplexes: Influence of buffer composition, oligonucleotide sequence, and hyaluronic acid coating. Journal of Colloid and Interface Science, 512, 335-345. Lien externe
Alameh, M., Lavertu, M., Tran-Khanh, N., Chang, C.-Y., Lesage, F., Bail, M., Darras, V., Chevrier, A., & Buschmann, M. D. (2018). siRNA delivery with chitosan: influence of chitosan molecular weight, degree of deacetylation, and amine to phosphate ratio on in vitro silencing efficiency, hemocompatibility, biodistribution, and in vivo efficacy. Biomacromolecules, 19(1), 112-131. Lien externe
Fong, D., Gregoire-Gelinas, P., Cheng, A. P., Mezheritsky, T., Lavertu, M., Sato, S., & Hoemann, C. D. (2017). Lysosomal rupture induced by structurally distinct chitosans either promotes a type 1 IFN response or activates the inflammasome in macrophages. Biomaterials, 129, 127-138. Disponible
Tavakoli Naeini, A., Soliman, O. Y., Alameh, M. G., Lavertu, M., & Buschmann, M. D. (2017). Automated in-line mixing system for large scale production of chitosan-based polyplexes. Journal of Colloid and Interface Science, 500, 253-263. Lien externe
Chevrier, A., Buschmann, M. D., Veilleux, D., Hoemann, C. D., & Lavertu, M. (2017). Freeze-dried polymer compositions for mixing with platelet rich plasma to form implants for tissue repair and/or compositions for therapeutic intra-articular injections. (Demande de brevet no US20170049696). Lien externe
Ouyang, W., Buschmann, M. D., Hoemann, C. D., Lavertu, M., & Chevrier, A. (2017). Novel formulation of physiological chitosan-inorganic salt solution/blood mixtures for tissue repair. (Demande de brevet no US20170333477). Lien externe
Pickenhahn, V., Grange, M., De Crescenzo, G., Lavertu, M., & Buschmann, M. D. (2017). Regioselective chitosan end-group activation: the triskelion approach. RSC Advances, 7(30), 18628-18638. Disponible
Ma, P. L., Lavertu, M., Winnik, F. M., & Buschmann, M. D. (2017). Stability and binding affinity of DNA/chitosan complexes by polyanion competition. Carbohydrate Polymers, 176, 167-176. Lien externe
Fong, D., Gregoire-Gelinas, P., Lavertu, M., Sato, S., & Hoemann, C. D. (mai 2016). Human macrophages release higher IL-1ra over IL-1beta when stimulated by block acetylated chitosan microparticles and not by random acetylated chitosans or water-soluble oligomers [Affiche]. 10th World Biomaterials Congress, Montréal, Québec. Publié dans Frontiers in Bioengineering and Biotechnology, 4. Disponible
Pickenhahn, V. D., Lavertu, M., Buschmann, M. D., De Crescenzo, G., & Darras, V. (2016). Conjugated chitosans and method of use and of making same. (Demande de brevet no WO2016101068). Lien externe
Buschmann, M. D., Lavertu, M., & Veilleux, D. (2016). Freeze-dried polyelectrolyte complexes that maintain size and biological activity. (Demande de brevet no US20160130606). Lien externe
Veilleux, D., Nelea, M., Biniecki, K., Lavertu, M., & Buschmann, M. D. (2016). Preparation of Concentrated Chitosan/DNA Nanoparticle Formulations by Lyophilization for Gene Delivery at Clinically Relevant Dosages. Journal of Pharmaceutical Sciences, 105(1), 88-96. Lien externe
Thibault, M., Lavertu, M., Astolfi, M., & Buschmann, M. D. (2016). Structure Dependence of Lysosomal Transit of Chitosan-Based Polyplexes for Gene Delivery. Molecular Biotechnology, 58(10), 648-656. Lien externe
Pickenhahn, V., Darras, V., Dziopa, F., Biniecki, K., De Crescenzo, G., Lavertu, M., & Buschmann, M. D. (2015). Regioselective thioacetylation of chitosan end-groups for nanoparticle gene delivery systems. Chemical Science, 6(8), 4650. Disponible
Alameh, M.-G., Lavertu, M., Merzouki, A., Biniecki, K., & Buschmann, M. D. (mai 2014). Chitosan/siRNA nanoparticles demonstrate superior silencing efficiency and lower toxicity compared to lipid nanoparticles [Résumé]. 17th Annual Meeting of the American Society of Gene & Cell Therapy, Washington, DC. Publié dans Molecular Therapy, 22(S1). Disponible
Veilleux, D., Lavertu, M., Biniecki, K., & Buschmann, M. D. (mai 2014). Lyophilized chitosan nanoparticles for pDNA and siRNA delivery: Physico-chemical properties, transfection efficiency, and cytotoxicity [Résumé]. American Society of Gene & Cell Therapy 17th Annual Meeting, Washington, DC. Publié dans Molecular Therapy, 22(S1). Disponible
Niebel, Y., Buschmann, M. D., Lavertu, M., & De Crescenzo, G. (2014). Combined Analysis of Polycation/ODN Polyplexes by Analytical Ultracentrifugation and Dynamic Light Scattering Reveals their Size, Refractive Index Increment, Stoichiometry, Porosity, and Molecular Weight. Biomacromolecules, 15(3), 940-947. Lien externe
Tavakoli Naeini, A., Lavertu, M., Buschmann, M. D., & Biniecki, K. (mai 2014). Large scale preparation of chitosan/nucleic acid nanoparticles using an automated inline mixing system [Résumé]. American Society of Gene & Cell Therapy 17th Annual Meeting, Washington, DC. Publié dans Molecular Therapy, 22. Disponible
Hoemann, C. D., Guzmán-Morales, J., Tran-Khanh, N., Lavallée, G., Jolicoeur, M., & Lavertu, M. (2013). Chitosan rate of uptake in HEK293 cells is influenced by soluble versus microparticle state and enhanced by serum-induced cell metabolism and lactate-based media acidification. Molecules, 18(1), 1015-1035. Disponible
Buschmann, M. D., Merzouki, A., Lavertu, M., Thibault, M., Jean, M., & Darras, V. (2013). Chitosans for delivery of nucleic acids. Advanced Drug Delivery Reviews, 65(9), 1234-1270. Lien externe
Chattopadhyahya, B., Sanon, N. T., Dominique, D. B., Lavertu, M., Berryer, M., Desgent, S., Salam, T., Carmant, L., & Dicristo, G. (juin 2013). Hypoxia-Induced Seizures Affect Interneuronal Network Maturation in the Mouse Hippocampus and Neocortex [Communication écrite]. 30th International Epilepsy Congress, Montréal, Canada. Publié dans Epilepsia, 54(S3). Lien externe
Richard, I., Thibault, M., De Crescenzo, G., Buschmann, M. D., & Lavertu, M. (2013). Ionization behavior of chitosan and chitosan-DNA polyplexes indicate that chitosan has a similar capability to induce a proton-sponge effect as PEI. Biomacromolecules, 14(6), 1732-1740. Lien externe
Jean, M., Alameh, M., De Jesus, D., Thibault, M., Lavertu, M., Darras, V., Nelea, M., Buschmann, M. D., & Merzouki, A. (2012). Chitosan-Based Therapeutic Nanoparticles for Combination Gene Therapy and Gene Silencing of in Vitro Cell Lines Relevant to Type 2 Diabetes. European Journal of Pharmaceutical Sciences, 45(1-2), 138-149. Lien externe
Lavertu, M., Darras, V., & Buschmann, M. D. (2012). Kinetics and efficiency of chitosan reacetylation. Carbohydrate Polymers, 87(2), 1192-1198. Lien externe
Merzouki, A., Alameh, M., DeJesus, D., Jean, M., Darras, V., Thibault, M., Lavertu, M., & Buschmann, M. D. (2012). Low molecular weight chitosan nanoparticulate system at low N:P ratio for nontoxic polynucleotide delivery. International Journal of Nanomedicine, 7, 1399-1414. Disponible
Jean, M., Alameh, M., Daras, V., Lavertu, M., Thibault, M., Buschmann, M. D., & Merzouki, A. (mai 2011). Effective and safe gene-based delivery of GLP-1 using chitosan/plasmid-DNA therapeutic nanocomplexes in an animal model of Type 2 Diabetes [Communication écrite]. 14th Annual Meeting American Society of Gene and Cell Therapy, Seattle, WA, USA. Non disponible
Jean, M., Alameh, M., Daras, V., Lavertu, M., Thibault, M., Buschmann, M. D., & Merzouki, A. (mai 2011). Effective and safe gene-based delivery of GLP-1 using chitosan/plasmid-DNA therapeutic nanocomplexes in an animal model of Type 2 Diabetes [Communication écrite]. 1st Meeting of Canadian Chapter of The Controlled Release Society, Montréal, Québec, Canada. Non disponible
Thibault, M., Astolfi, M., Tran-Khanh, N., Lavertu, M., Darras, V., Merzouki, A., & Buschmann, M. D. (mai 2011). Excess polycation mediates efficient chitosan-based gene transfer by promoting lysosomal release of the polyplexes [Communication écrite]. 1st Meeting of Canadian Chapter of The Controlled Release Society, Montréal, Québec. Non disponible
Thibault, M., Astolfi, M., Tran-Khanh, N., Lavertu, M., Darras, V., Merzouki, A., & Buschmann, M. D. (2011). Excess polycation mediates efficient chitosan-based gene transfer by promoting lysosomal release of the polyplexes. Biomaterials, 32(20), 4639-4646. Lien externe
Thibault, M., Astolfi, M., Lavertu, M., Darras, M., & Buschmann, M. D. (mai 2011). The role and fate of excess polycations in efficient chitosan-based gene transfection [Communication écrite]. 14th Annual Meeting American Society of Gene and Cell Therapy, Seattle, WA. Non disponible
Nimesh, S., Thibault, M., Lavertu, M., & Buschmann, M. D. (2010). Enhanced gene delivery mediated by low molecular weight chitosan/DNA complexes: effect of pH and serum. Molecular Biotechnology, 46(2), 182-96. Disponible
Thibault, M., Nimesh, S., Lavertu, M., & Buschmann, M. D. (2010). Intracellular Trafficking and Decondensation Kinetics of Chitosan–pDNA Polyplexes. Molecular Therapy, 18(10), 1787-1795. Disponible
Thibault, M., Nimesh, S., Lavertu, M., & Buschmann, M. D. (mai 2010). Intracellular trafficking and decondensation kinetics of chitosan-pDNA Polyplexes [Communication écrite]. 13th Annual Meeting of American Society of Gene and Cell Therapy, Washington, DC. Non disponible
Buschmann, M. D., Thibault, M., Merzouki, A., Lavertu, M., Ma, P. L., Jean, M., Darras, V., & Winnik, F. M. (mai 2010). Polynucleotide delivery with chitosans [Communication écrite]. 93rd Canadian Chemistry Conference, Toronto, Ontario. Non disponible
Jean, M., Smaoui, F., Lavertu, M., Methot, S., Bouhdoud, L., Buschmann, M. D., & Merzouki, A. (2009). Chitosan-Plasmid Nanoparticle Formulations for Im and Sc Delivery of Recombinant Fgf-2 and Pdgf-Bb or Generation of Antibodies. Gene Therapy, 16(9), 1097-1110. Lien externe
Pei, L. M., Lavertu, M., Winnik, F. M., & Buschmann, M. D. (2009). New insights into chitosan-DNA interactions using isothermal titration microcalorimetry. Biomacromolecules, 10(6), 1490-1499. Lien externe
Buschmann, M. D., Thibault, M., Merzouki, A., & Lavertu, M. (août 2009). Polynucleotide delivery with chitosans [Communication écrite]. 8th World Congress of Chemical Engineering, Montréal, Québec. Non disponible
Lavertu, M., Filion, D., & Buschmann, M. D. (2008). Heat-Induced Transfer of Protons From Chitosan to Glycerol Phosphate Produces Chitosan Precipitation and Gelation. Biomacromolecules, 9(2), 640-650. Lien externe
Nelea, M., Lavertu, M., Ma, P. L., & Buschmann, M. D. (mai 2008). Imaging of chitosan-plasmid DNA nanoparticles by scanning electron microscopy and atomic force microscopy [Communication écrite]. Microscopical Society of Canada Meeting, Montréal, Québec. Non disponible
Thibault, M., Nimesh, S., Janta-Polanski, M., Lavertu, M., & Buschmann, M. D. (octobre 2008). Intercellular trafficking and dissociation kinetics of specific chitosan-pDNA polyplexes [Communication écrite]. 6th International Nanomedicine and Drug Delivery Symposium, Toronto, ON, Canada. Non disponible
Ma, O., Lavertu, M., Sun, J., Nguyen, S., Buschmann, M. D., Winnik, F. M., & Hoemann, C. D. (2008). Precise Derivatization of Structurally Distinct Chitosans With Rhodamine B Isothiocyanate. Carbohydrate polymer, 72(4), 616-624. Lien externe
Lavertu, M. (2007). Caractérisation du système thermosensible chitosane-glycérol phosphate et applications pour la livraison de gènes [Thèse de doctorat, École Polytechnique de Montréal]. Disponible
Tran-Khanh, N., Lavertu, M., Hoemann, C. D., & Buschmann, M. D. (février 2007). Chondrocyte proliferation at the agarose-media interface resembles appositional mechanisms of the epiphyseal growth plate [Communication écrite]. 53rd Annual Meeting of the Orthopaedic Research Society, San Diego, CA, USA. Lien externe
Méthot, S., Lavertu, M., Sun, J., Smaoui, F., Jean, M., Merzouki, A., & Buschmann, M. D. (septembre 2007). Efficient in vivo gene delivery using chitosan/DNA nanoparticles for applications in cartilage repair [Communication écrite]. 7th World Congress International Society for Cartilage Repair, Warsaw, Poland. Lien externe
Filion, D., Lavertu, M., & Buschmann, M. D. (2007). Ionization and Solubility of Chitosan Solutions Related to Thermosensitive Chitosan/Glycerol-Phosphate Systems. Biomacromolecules, 8(10), 3224-3234. Lien externe
Tran-Khanh, N., Lavertu, M., Lascau-Coman, V., Hoemann, C. D., & Buschmann, M. D. (septembre 2007). Time-lapse confocal imaging of living chondrocytes in appositionally developing outgrowths at the agarose-media interface [Communication écrite]. 7th World Congress International Society for Cartilage Repair, Warsaw, Poland. Lien externe
Tran-Khanh, N., Lavertu, M., Hoemann, C. D., & Buschmann, M. D. (octobre 2006). Chondrocyte proliferation at the agarose-media interface resembles appositional mechanisms of the epiphyseal growth plate [Communication écrite]. Transactions 56th Canadian Chemical Engineering Conference, Sherbrooke, QC. Non disponible
Hoemann, C. D., Ma, O., Lavertu, M., Lavalée, G., Sun, J., El-Gabalawy, H., Tran-Khanh, N., & Winnik, F. (mai 2006). Controlled derivatization of chitosan with rhodamine B-isothiocyanate to study the influence of chitosan structure on stromal cell recognition and uptake [Communication écrite]. Can Workshop on Pre-Clinical OA models, Montréal, Québec. Non disponible
Méthot, S., Lavertu, M., Ma, P. L., Winnik, F., & Buschmann, M. D. (septembre 2006). High Efficiency Gene Transfer Using Chitosan/DNA Nanoparticles With Specific Combinations of Molecular Weight and Degree of Deacetylation [Communication écrite]. Transactions 10th International Conference on Chitin and Chitosan, Montpellier, France. Non disponible
Lavertu, M., Méthot, S., Tran-Khanh, N., & Buschmann, M. D. (2006). High Efficiency Gene Transfer Using Chitosan/DNA Nanoparticles With Specific Combinations of Molecular Weight and Degree of Deacetylation. Biomaterials, 27(27), 4815-4824. Lien externe
Lavertu, M., Filion, D., Schmid, A., Zayani, M., & Buschmann, M. D. (septembre 2006). Studies on the mechanism of thermal gelation of chitosan-glycerol phosphate solutions [Communication écrite]. Transactions 10th International Conference on Chitin and Chitosan, Montpellier, France. Non disponible
Lavertu, M., Filion, D., Schmid, A., Zayani, M., & Buschmann, M. D. (octobre 2006). Studies on the mechanism of thermal gelation of chitosan-glycerol phosphate solutions [Communication écrite]. Transactions 56th Canadian Chemical Engineering Conference, Sherbrooke, Québec, Canada. Non disponible
Filion, D., Lavertu, M., & Buschmann, M. D. (juin 2004). Ionization-state dependent behavior of chitosan solutions : Theory and experiments [Communication écrite]. Transactions Polyelectrolytes, Amherst, Massachusetts, USA. Non disponible
Lavertu, M., Methot, S., & Buschmann, M. D. (juin 2004). Nanoparticules polymeres-ADN pour le transfert de gène [Communication écrite]. Nanobiointerfaces pour les dispositifs intelligents, 17ième Entretiens du Centre Jacques Cartier, Montréal, Québec. Non disponible
Lavertu, M., Xia, Z., Serreqi, A. N., Berrada, M., Rodrigues, A., Wang, D., Buschmann, M. D., & Gupta, A. (2003). A validated ¹H NMR method for the determination of the degree of deacetylation of chitosan. Journal of pharmaceutical and biomedical analysis, 32(6), 1149-1158. Lien externe
Buschmann, M. D., Garon, M., Ouellet, M., & Lavertu, M. (2001). Universal mechanical testing device. (Brevet no US6332364). Lien externe
