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Reyes, S.‐J., Lemire, L., Roy, M., LʹÉcuyer-Coelho, H., Martynova, Y., Cass, B., Voyer, R., Durocher, Y., Henry, O., Pham, P. L., & Molina, R.-S. (2024). Multivariate data analysis of process parameters affecting the growth and productivity of stable Chinese hamster ovary cell pools expressing SARS‐CoV‐2 spike protein as vaccine antigen in early process development. Biotechnology Progress, e3467 (19 pages). Available
Gaudreault, J., Forest‐Nault, C., Gilbert, M., Durocher, Y., Henry, O., & De Crescenzo, G. (2024). A low‐temperature SPR‐based assay for monoclonal antibody galactosylation and fucosylation assessment using FcγRIIA/B. Biotechnology and Bioengineering, 15 pages. Available
Forest-Nault, C., Koyuturk, I., Gaudreault, J., Pelletier, A., L’Abbé, D., Cass, B., Bisson, L., Burlacu, A., Delafosse, L., Stuible, M., Henry, O., De Crescenzo, G., & Durocher, Y. (2024). A Biosensor Assay Based on Coiled-Coil-Mediated Human ACE2 Receptor Capture for the Analysis of Its Interactions with the SARS-CoV-2 Receptor Binding Domain. In Bradfute, S. B. (ed.), Recombinant Glycoproteins: Methods and Protocols (pp. 89-105). External link
Gaudreault, J., Forest-Nault, C./.H., Gilbert, M., Durocher, Y., Henry, O., & De Crescenzo, G. (2024). A low-temperature SPR-based assay for monoclonal antibody galactosylation and fucosylation assessment using FcγRIIA/B. Biotechnology & Bioengineering, 121(5), 1659-1673. External link
Reyes, S.-J., Lemire, L., Molina, R.-S., Roy, M., L'Ecuyer-Coelho, H., Martynova, Y., Cass, B., Voyer, R., Durocher, Y., Henry, O., & Pham, P. L. (2024). Multivariate data analysis of process parameters affecting the growth and productivity of stable Chinese hamster ovary cell pools expressing SARS-CoV-2 spike protein as vaccine antigen in early process development. Biotechnology Progress, 19 pages. External link
Baniahmad, S. F., Oliverio, R., Obregon-Gomez, I., Robert, A., Lenferink, A. E. G., Pazos, E., Virgilio, N., Banquy, X., De Crescenzo, G., & Durocher, Y. (2023). Affinity-controlled capture and release of engineered monoclonal antibodies by macroporous dextran hydrogels using coiled-coil interactions. mAbs, 15(1), 2218951 (18 pages). External link
Dégardin, M., Liberelle, B., Oliverio, R., Baniahmad, S. F., Darviot, C., Largillière, I., Henry, O., Durocher, Y., Banquy, X., Meunier, M., & De Crescenzo, G. (2023). Coiled-coil-based biofunctionalization of 100 nm gold nanoparticles with the trastuzumab antibody for the detection of HER2-positive cancer cells. Langmuir, 39(34), 12235-12247. External link
Forest-Nault, C., Koyuturk, I., Gaudreault, J., Pelletier, A., L'Abbé, D., Cass, B., Bisson, L., Burlacu, A., Delafosse, L., Stuible, M., Henry, O., De Crescenzo, G., & Durocher, Y. (2022). Impact of the temperature on the interactions between common variants of the SARS-CoV-2 receptor binding domain and the human ACE2. Scientific Reports, 12(1), 11520 (11 pages). External link
Reyes, S. J., Durocher, Y., Pham, P. L., & Henry, O. (2022). Modern Sensor Tools and Techniques for Monitoring, Controlling, and Improving Cell Culture Processes. Processes, 10(2), 189 (36 pages). External link
Gaudreault, J., Durocher, Y., Henry, O., & De Crescenzo, G. (2022). Multi-temperature experiments to ease analysis of heterogeneous binder solutions by surface plasmon resonance biosensing. Scientific Reports, 12(1), 14401 (25 pages). External link
Forest-Nault, C., Gaudreault, J., Henry, O., Durocher, Y., & De Crescenzo, G. (2021). On the use of surface plasmon resonance biosensing to understand IgG-FcγR interactions. International Journal of Molecular Sciences, 22(12), 6616 (27 pages). Available
Gaudreault, J., Liberelle, B., Durocher, Y., Henry, O., & De Crescenzo, G. (2021). Determination of the composition of heterogeneous binder solutions by surface plasmon resonance biosensing. Scientific Reports, 11(1), 3685 (16 pages). Available
Gaudreault, J., Forest-Nault, C., De Crescenzo, G., Durocher, Y., & Henry, O. (2021). On the Use of Surface Plasmon Resonance-Based Biosensors for Advanced Bioprocess Monitoring. Processes, 9(11), 1996 (28 pages). External link
Lemire, L., Pham, P. L., Durocher, Y., & Henry, O. (2021). Practical Considerations for the Scale-Up of Chinese Hamster Ovary (CHO) Cell Cultures. In Cell Culture Engineering and Technology: In appreciation to Professor Mohamed Al-Rubeai (Vol. 10, pp. 367-400). External link
Cambay, F., Forest-Nault, C., Dumoulin, L., Seguin, A., Henry, O., Durocher, Y., & De Crescenzo, G. (2020). Glycosylation of Fcγ receptors influences their interaction with various IgG1 glycoforms. Molecular Immunology, 121, 144-158. External link
Cambay, F., Raymond, C., Brochu, D., Gilbert, M., Tu, T. M., Cantin, C., Lenferink, A., Grail, M., Henry, O., De Crescenzo, G., & Durocher, Y. (2020). Impact of IgG1 N-glycosylation on their interaction with Fc gamma receptors. Current Research in Immunology, 1, 23-37. External link
Mellahi, K., Brochu, D., Gilbert, M., Perrier, M., Ansorge, S., Durocher, Y., & Henry, O. (2019). Assessment of fed-batch cultivation strategies for an inducible CHO cell line. Journal of Biotechnology, 298, 45-56. External link
Cambay, F., Henry, O., Durocher, Y., & De Crescenzo, G. (2019). Impact of N-glycosylation on Fcγ receptor / IgG interactions: unravelling differences with an enhanced surface plasmon resonance biosensor assay based on coiled-coil interactions. mAbs, 11(3), 435-452. External link
Mellahi, K., Cambay, F., Brochu, D., Gilbert, M., Perrier, M., Ansorge, S., Durocher, Y., & Henry, O. (2019). Process development for an inducible rituximab-expressing Chinese hamster ovary cell line. Biotechnology Progress, 35(1), e2742. External link
Mellahi, K., Brochu, D., Gilbert, M., Perrier, M., Ansorge, S., Durocher, Y., & Henry, O. (2019). Process intensification for the production of rituximab by an inducible CHO cell line. Bioprocess and Biosystems Engineering, 42(5), 711-725. External link
Karengera, E., Robotham, A., Kelly, J., Durocher, Y., De Crescenzo, G., & Henry, O. (2018). Concomitant reduction of lactate and ammonia accumulation in fed-batch cultures: Impact on glycoprotein production and quality. Biotechnology Progress, 34(2), 494-504. External link
Durocher, Y., Toussaint, C., & Henry, O. (2018, May). Regulation of recombinant protein expression during CHO pool selection enhances high producer frequency [Paper]. Cell Culture Engineering XVI, Tampa, FL. Unavailable
Karengera, E., Robotham, A., Kelly, J., Durocher, Y., De Crescenzo, G., & Henry, O. (2017). Altering the central carbon metabolism of HEK293 cells: Impact on recombinant glycoprotein quality. Journal of Biotechnology, 242, 73-82. External link
Riahi, N., Murschel, F., Lerouge, S., Durocher, Y., Henry, O., & De Crescenzo, G. (2017). Bioavailability of immobilized epidermal growth factor: Covalent versus noncovalent grafting. Biointerphases, 12(1), 010501 (8 pages). External link
Karengera, E., Durocher, Y., De Crescenzo, G., & Henry, O. (2017). Combining metabolic and process engineering strategies to improve recombinant glycoprotein production and quality. Applied Microbiology and Biotechnology, 101(21), 7837-7851. External link
Dorion-Thibaudeau, J., Durocher, Y., & De Crescenzo, G. (2017). Quantification and simultaneous evaluation of the bioactivity of antibody produced in CHO cell culture-The use of the ectodomain of Fc gamma RI and surface plasmon resonance-based biosensor. Molecular Immunology, 82, 46-49. External link
Karengera, E., De Crescenzo, G., Durocher, Y., & Henry, O. (2016, May). Improving the metabolic efficiency of mammalian cells and its impact on glycoproteins quality [Poster]. Cell Culture Engineering XV, Palm Spring (CA). Unavailable
Toussaint, C., Henry, O., & Durocher, Y. (2016). Metabolic engineering of CHO cells to alter lactate metabolism during fed-batch cultures. Journal of Biotechnology, 217(C), 122-131. Available
Arnold, E., Hammami, I., Chen, J., Gupte, S., Durocher, Y., & Jolicoeur, M. (2016). Overexpression of G6PDH does not affect the behavior of HEK-293 clones stably expressing interferon-α2b. AIMS Bioengineering, 3(3), 319-336. Available
Fortier, C., Louvier, E., Durocher, Y., & De Crescenzo, G. (2015). Tailoring the surface of a gene delivery vector with carboxymethylated dextran: A systematic analysis. Biomacromolecules, 16(6), 1671-1681. External link
Vallee, C., Durocher, Y., & Henry, O. (2014). Exploiting the metabolism of PYC expressing HEK293 cells in fed-batch cultures. Journal of Biotechnology, 169(1), 63-70. External link
Fortier, C., Durocher, Y., & De Crescenzo, G. (2014). Surface modification of nonviral nanocarriers for enhanced gene delivery. Nanomedicine, 9(1), 135-151. External link
Dorion-Thibaudeau, J., Raymond, C., Lattova, E., Perreault, H., Durocher, Y., & De Crescenzo, G. (2014). Towards the development of a surface plasmon resonance assay to evaluate the glycosylation pattern of monoclonal antibodies using the extracellular domains of CD16a and CD64. Journal of Immunological Methods, 408, 24-34. External link
Fortier, C., De Crescenzo, G., & Durocher, Y. (2013). A versatile coiled-coil tethering system for the oriented display of ligands on nanocarriers for targeted gene delivery. Biomaterials, 34(4), 1344-1353. External link
Henry, O., & Durocher, Y. (2011). Enhanced glycoprotein production in HEK-293 cells expressing pyruvate carboxylase. Metabolic Engineering, 13(5), 499-507. External link
Henry, O., & Durocher, Y. (2010, July). Engineering of the Human Cell Line HEK-293 to Enhance Recombinant Protein Production [Paper]. 11th IFAC Symposium on Computer Applications in Bioitechnology (CAB 2020), Leuven, Belgium. Published in IFAC Proceedings Volumes, 43(6). External link
Boucher, C., Ruiz, J.-C., Thibault, M., Buschmann, M. D., Wertheimer, M. R., Jolicoeur, M., Durocher, Y., & De Crescenzo, G. (2010). Human corneal epithelial cell response to epidermal growth factor tethered via coiled-coil interactions. Biomaterials, 31(27), 7021-7031. External link
Liberelle, B., Bartholin, L., Boucher, C., Murschel, F., Jolicoeur, M., Durocher, Y., Merzouki, A., & De Crescenzo, G. (2010). New Elisa Approach Based on Coiled-Coil Interactions. Journal of Immunological Methods, 362(1-2), 161-167. External link
Boucher, C., St-Laurent, G., Jolicoeur, M., De Crescenzo, G., & Durocher, Y. (2010). Protein Detection by Western Blot Via Coiled-Coil Interactions. Analytical Biochemistry, 399(1), 138-140. External link
Ansorge, S., Lanthier, S., Transfiguracion, J., Durocher, Y., Henry, O., & Kamen, A. (2009). Development of a Scalable Process for High-Yield Lentiviral Vector Production by Transient Transfection of Hek293 Suspension Cultures. Journal of Gene Medicine, 11(10), 868-876. External link
Boucher, C., Liberelle, B., Jolicoeur, M., Durocher, Y., & De Crescenzo, G. (2009). Epidermal Growth Factor Tethered Through Coiled-Coil Interactions Induces Cell Surface Receptor Phosphorylation. Bioconjugate Chemistry, 20(8), 1569-1577. External link
Boucher, C., St-Laurent, G., Loignon, M., Jolicoeur, M., De Crescenzo, G., & Durocher, Y. (2008). The Bioactivity and Receptor Affinity of Recombinant Tagged Egf Designed for Tissue Engineering Applications Is Defined by the Nature and Position of the Tags. Tissue Engineering, Part A, 14(12), 2069-2077. External link
De Crescenzo, G., Chao, H., Zwaagstra, J., Durocher, Y., & O'Connor-McCourt, M. D. (2008). Engineering TGF-β Traps: Artificially Dimerized Receptor Ectodomains as High-affinity Blockers of TGF-β Action. In Transforming Growth Factor-β in Cancer Therapy, Volume II (pp. 671-684). External link
De Crescenzo, G., Pham, P. L., Durocher, Y., Chao, H., & O'Connor-McCourt, M. D. (2004). MECHANISMS OF SIGNAL TRANSDUCTION-Enhancement of the Antagonistic Potency of Transforming Growth Factor-b Receptor Extracellular Domains by Coiled Coil-induced Homo-and Heterodimerization. Journal of Biological Chemistry, 279(25), 26013-26018. External link
