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Quantitative pulsatility measurements using 3D dynamic ultrasound localization microscopy

Chloé Bourquin, Jonathan Porée, Brice Rauby, Vincent Gaël Perrot, Nin Ghigo, Hatim Belgharbi, Samuel Bélanger, Gerardo Ramos-Palacios, Nelson Cortes, Hugo Ladret, Lamyae Ikan, Christian Casanova, Frédéric Lesage and Jean Provost

Article (2024)

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Abstract

A rise in blood flow velocity variations (i.e. pulsatility) in the brain, caused by the stiffening of upstream arteries, is associated with cognitive impairment and neurodegenerative diseases. The study of this phenomenon requires brain-wide pulsatility measurements, with large penetration depth and high spatiotemporal resolution. The development of dynamic ultrasound localization microscopy (DULM), based on ULM, has enabled pulsatility measurements in the rodent brain in 2D. However, 2D imaging accesses only one slice of the brain and measures only 2D-projected and hence biased velocities . Herein, we present 3D DULM: using a single ultrasound scanner at high frame rate (1000–2000 Hz), this method can produce dynamic maps of microbubbles flowing in the bloodstream and extract quantitative pulsatility measurements in the cat brain with craniotomy and in the mouse brain through the skull, showing a wide range of flow hemodynamics in both large and small vessels. We highlighted a decrease in pulsatility along the vascular tree in the cat brain, which could be mapped with ultrasound down to a few tens of micrometers for the first time. We also performed an intra-animal validation of the method by showing consistent measurements between the two sides of the Willis circle in the mouse brain. Our study provides the first step towards a new biomarker that would allow the detection of dynamic abnormalities in microvessels in the brain, which could be linked to early signs of neurodegenerative diseases.

Uncontrolled Keywords

dynamic ultrasound localization microscopy; 3D brain imaging; pulsatility index; Kalman filtering

Additional Information: Matériel supplémentaire disponible en ligne (2 vidéos)
Subjects: 1900 Biomedical engineering > 1900 Biomedical engineering
1900 Biomedical engineering > 1901 Biomedical technology
2500 Electrical and electronic engineering > 2500 Electrical and electronic engineering
3100 Physics > 3100 Physics
Department: Department of Electrical Engineering
Department of Engineering Physics
Funders: NSERC / CRSNG, Institute for Data Valorization (IVADO), Canada Foundation for Innovation, Canadian Institutes of Health Research (CIHR), New Frontiers in Research Fund, TransMedTech Institute, Fonds de recherche du Québec - Nature et technologies, Quebec Bio-Imaging Network, Canada First Research Excellence Fund (Apogée/CFREF), Calcul Québec, Digital Research Alliance of Canada
Grant number: 38095, 452530, NFRFE-2018–01312, RGPIN2019–04982
PolyPublie URL: https://publications.polymtl.ca/57387/
Journal Title: Physics in Medicine and Biology (vol. 69, no. 4)
Publisher: IOP Publishing Ltd
DOI: 10.1088/1361-6560/ad1b68
Official URL: https://doi.org/10.1088/1361-6560/ad1b68
Date Deposited: 28 Feb 2024 14:05
Last Modified: 02 May 2024 01:57
Cite in APA 7: Bourquin, C., Porée, J., Rauby, B., Perrot, V. G., Ghigo, N., Belgharbi, H., Bélanger, S., Ramos-Palacios, G., Cortes, N., Ladret, H., Ikan, L., Casanova, C., Lesage, F., & Provost, J. (2024). Quantitative pulsatility measurements using 3D dynamic ultrasound localization microscopy. Physics in Medicine and Biology, 69(4), 045017 (14 pages). https://doi.org/10.1088/1361-6560/ad1b68

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