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Diffusion Kurtosis Imaging of Neonatal Spinal Cord in Clinical Routine

Rosella Trò, Monica Roascio, Domenico Tortora, Mariasavina Severino, Andrea Rossi, Julien Cohen-Adad, Marco Fato and Gabriele Arnulfo

Article (2022)

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Abstract

Diffusion kurtosis imaging (DKI) has undisputed advantages over the more classical diffusionmagnetic resonance imaging (dMRI) as witnessed by the fast-increasing number of clinical applications and software packages widely adopted in brain imaging. However, in the neonatal setting, DKI is still largely underutilized, in particular in spinal cord (SC) imaging, because of its inherently demanding technological requirements. Due to its extreme sensitivity to non-Gaussian diffusion, DKI proves particularly suitable for detecting complex, subtle, fast microstructural changes occurring in this area at this early and critical stage of development, which are not identifiable with only DTI. Given the multiplicity of congenital anomalies of the spinal canal, their crucial effect on later developmental outcome, and the close interconnection between the SC region and the brain above, managing to apply such a method to the neonatal cohort becomes of utmost importance. This study will (i) mention current methodological challenges associated with the application of advanced dMRI methods, like DKI, in early infancy, (ii) illustrate the first semi-automated pipeline built on Spinal Cord Toolbox for handling the DKI data of neonatal SC, from acquisition setting to estimation of diffusion measures, through accurate adjustment of processing algorithms customized for adult SC, and (iii) present results of its application in a pilot clinical case study. With the proposed pipeline, we preliminarily show that DKI is more sensitive than DTI-related measures to alterations caused by brain white matter injuries in the underlying cervical SC.

Uncontrolled Keywords

spinal cord; diffusion tensor imaging (DTI); diffusion kurtosis imaging (DKI); image processing pipeline; neonatal imaging; punctate white matter lesions

Subjects: 2500 Electrical and electronic engineering > 2524 Ultrasonic/ferroelectric devices and applications
9000 Health sciences > 9000 Health sciences
Department: Department of Electrical Engineering
Institut de génie biomédical
Research Center: NeuroPoly - Laboratoire de Recherche en Neuroimagerie
PolyPublie URL: https://publications.polymtl.ca/54325/
Journal Title: Frontiers in Radiology (vol. 2)
Publisher: Frontiers Media
DOI: 10.3389/fradi.2022.794981
Official URL: https://doi.org/10.3389/fradi.2022.794981
Date Deposited: 02 Nov 2023 12:53
Last Modified: 24 Apr 2024 12:42
Cite in APA 7: Trò, R., Roascio, M., Tortora, D., Severino, M., Rossi, A., Cohen-Adad, J., Fato, M., & Arnulfo, G. (2022). Diffusion Kurtosis Imaging of Neonatal Spinal Cord in Clinical Routine. Frontiers in Radiology, 2, 794981 (18 pages). https://doi.org/10.3389/fradi.2022.794981

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