Jan Valošek, René Labounek, Tomáš Horák, Magda Horáková, Petr Bednařík, Miloš Keřkovský, Jan Kočica, Tomáš Rohan, Christophe Lenglet, Julien Cohen-Adad
, Petr Hluštík, Eva Vlčková, Zdeněk Kadaňka, Josef Bednařík and Alena Svatkova
Article (2021)
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Abstract
Background and purpose: Non- myelopathic degenerative cervical spinal cord compres-sion (NMDC) frequently occurs throughout aging and may progress to potentially irre-versible degenerative cervical myelopathy (DCM). Whereas standard clinical magnetic resonance imaging (MRI) and electrophysiological measures assess compression sever-ity and neurological dysfunction, respectively, underlying microstructural deficits still have to be established in NMDC and DCM patients. The study aims to establish tract- specific diffusion MRI markers of electrophysiological deficits to predict the progression of asymptomatic NMDC to symptomatic DCM.
Methods: High-resolution 3 T diffusion MRI was acquired for 103 NMDC and 21 DCM patients compared to 60 healthy controls to reveal diffusion alterations and relation-ships between tract-specific diffusion metrics and corresponding electrophysiological measures and compression severity. Relationship between the degree of DCM disability, assessed by the modified Japanese Orthopaedic Association scale, and tract-specific mi-crostructural changes in DCM patients was also explored.
Results: The study identified diffusion-derived abnormalities in the gray matter, dor-sal and lateral tracts congruent with trans-synaptic degeneration and demyelination in chronic degenerative spinal cord compression with more profound alterations in DCM than NMDC. Diffusion metrics were affected in the C3-6 area as well as above the com-pression level at C3 with more profound rostral deficits in DCM than NMDC. Alterations in lateral motor and dorsal sensory tracts correlated with motor and sensory evoked po-tentials, respectively, whereas electromyography outcomes corresponded with gray mat-ter microstructure. DCM disability corresponded with microstructure alteration in lateral columns.
Conclusions: Outcomes imply the necessity of high- resolution tract-specific diffusion MRI for monitoring degenerative spinal pathology in longitudinal studies.
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| Department: |
Department of Electrical Engineering Institut de génie biomédical |
| Research Center: | NeuroPoly - Laboratoire de Recherche en Neuroimagerie |
| Funders: | Czech Health Research Council, Czech Republic - Ministry of Health - Project for conceptual development in research organizations, Austrian Agency for International Cooperation in Education and Research (OeAD-GmbH) - Aktion Österreich-Tschechien, AÖCZ-Semesterstipendien - Scholarship, European Union's Horizon 2020 research and innovation programme, Marie Skłodowska-Curie grant, NARSAD Young Investigator Grant from the Brain and Behavior Research Foundation, NIH, Canada Research Chair in Quantitative Magnetic Resonance Imaging, Canadian Institute of Health Research, Canada Foundation for Innovation, Fonds de Recherche du Québec - Santé, CRSNG/NSERC, Canada First Research Excellence Fund (IVADO and TransMedTech), Courtois NeuroMod project, Quebec BioImaging Network |
| Grant number: | NV18-04-00159, MPC-2020-00013, 65269705, 794986, 27238, 846793, P41 EB027061, P30 NS076408, 950-230815, CIHR FDN-143263, 32454, 34824, 28826, RGPIN-2019-07244, 5886, 35450 |
| PolyPublie URL: | https://publications.polymtl.ca/9337/ |
| Journal Title: | European Journal of Neurology (vol. 28, no. 11) |
| Publisher: | John Wiley & Sons |
| DOI: | 10.1111/ene.15027 |
| Official URL: | https://doi.org/10.1111/ene.15027 |
| Date Deposited: | 17 Aug 2023 09:55 |
| Last Modified: | 20 Mar 2026 19:15 |
| Cite in APA 7: | Valošek, J., Labounek, R., Horák, T., Horáková, M., Bednařík, P., Keřkovský, M., Kočica, J., Rohan, T., Lenglet, C., Cohen-Adad, J., Hluštík, P., Vlčková, E., Kadaňka, Z., Bednařík, J., & Svatkova, A. (2021). Diffusion magnetic resonance imaging reveals tract‐specific microstructural correlates of electrophysiological impairments in non‐myelopathic and myelopathic spinal cord compression. European Journal of Neurology, 28(11), 3784-3797. https://doi.org/10.1111/ene.15027 |
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