<  Back to the Polytechnique Montréal portal

Cerebral functional networks during sleep in young and older individuals

Véronique Daneault, Pierre Orban, Nicolas Martin, Christian Dansereau, Jonathan Godbout, Philippe Pouliot, Philip Dickinson, Nadia Gosselin, Gilles Vandewalle, Pierre Maquet, Jean-Marc Lina, Julien Doyon, Pierre Bellec and Julie Carrier

Article (2021)

Open Acess document in PolyPublie and at official publisher
[img]
Preview
Open Access to the full text of this document
Published Version
Terms of Use: Creative Commons Attribution
Download (1MB)
[img]
Preview
Open Access to the full text of this document
Supplemental Material
Terms of Use: Creative Commons Attribution
Download (1MB)
Show abstract
Hide abstract

Abstract

Even though sleep modification is a hallmark of the aging process, age-related changes in functional connectivity using functional Magnetic Resonance Imaging (fMRI) during sleep, remain unknown. Here, we combined electroencephalography and fMRI to examine functional connectivity differences between wakefulness and light sleep stages (N1 and N2 stages) in 16 young (23.1 ± 3.3y; 7 women), and 14 older individuals (59.6 ± 5.7y; 8 women). Results revealed extended, distributed (inter-between) and local (intra-within) decreases in network connectivity during sleep both in young and older individuals. However, compared to the young participants, older individuals showed lower decreases in connectivity or even increases in connectivity between thalamus/basal ganglia and several cerebral regions as well as between frontal regions of various networks. These findings reflect a reduced ability of the older brain to disconnect during sleep that may impede optimal disengagement for loss of responsiveness, enhanced lighter and fragmented sleep, and contribute to age effects on sleep-dependent brain plasticity.

Uncontrolled Keywords

Circadian rhythms and sleep ; Neural ageing

Subjects: 1900 Biomedical engineering > 1900 Biomedical engineering
1900 Biomedical engineering > 1901 Biomedical technology
2500 Electrical and electronic engineering > 2500 Electrical and electronic engineering
Department: Department of Electrical Engineering
Research Center: Other
Funders: Canadian Institutes of Health Research
Grant number: 93733
PolyPublie URL: https://publications.polymtl.ca/9294/
Journal Title: Scientific Reports (vol. 11)
Publisher: Springer Nature
DOI: 10.1038/s41598-021-84417-0
Official URL: https://doi.org/10.1038/s41598-021-84417-0
Date Deposited: 27 Feb 2023 11:57
Last Modified: 21 Sep 2023 12:37
Cite in APA 7: Daneault, V., Orban, P., Martin, N., Dansereau, C., Godbout, J., Pouliot, P., Dickinson, P., Gosselin, N., Vandewalle, G., Maquet, P., Lina, J.-M., Doyon, J., Bellec, P., & Carrier, J. (2021). Cerebral functional networks during sleep in young and older individuals. Scientific Reports, 11, 4905 (12 pages). https://doi.org/10.1038/s41598-021-84417-0

Statistics

Total downloads

Downloads per month in the last year

Origin of downloads

Dimensions

Repository Staff Only

View Item View Item