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Altered functional connectivity following an inflammatory white matter injury in the newborn rat: A high spatial and temporal resolution intrinsic optical imaging study

Edgar Guevara, Wyston C. Pierre, Camille Tessier, Luis Akakpo, Irène Londono, Frédéric Lesage and Gregory A. Lodygensky

Article (2017)

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Cite this document: Guevara, E., Pierre, W. C., Tessier, C., Akakpo, L., Londono, I., Lesage, F. & Lodygensky, G. A. (2017). Altered functional connectivity following an inflammatory white matter injury in the newborn rat: A high spatial and temporal resolution intrinsic optical imaging study. Frontiers in Neuroscience, 11. doi:10.3389/fnins.2017.00358
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Abstract

Very preterm newborns have an increased risk of developing an inflammatory cerebral white matter injury that may lead to severe neuro-cognitive impairment. In this study we performed functional connectivity (fc) analysis using resting-state optical imaging of intrinsic signals (rs-OIS) to assess the impact of inflammation on resting-state networks (RSN) in a pre-clinical model of perinatal inflammatory brain injury. Lipopolysaccharide (LPS) or saline injections were administered in postnatal day (P3) rat pups and optical imaging of intrinsic signals were obtained 3 weeks later. (rs-OIS) fc seed-based analysis including spatial extent were performed. A support vector machine (SVM) was then used to classify rat pups in two categories using fc measures and an artificial neural network (ANN) was implemented to predict lesion size from those same fc measures. A significant decrease in the spatial extent of fc statistical maps was observed in the injured group, across contrasts and seeds ((*)p = 0.0452 for HbO2 and (**)p = 0.0036 for HbR). Both machine learning techniques were applied successfully, yielding 92% accuracy in group classification and a significant correlation r = 0.9431 in fractional lesion volume prediction ((**)p = 0.0020). Our results suggest that fc is altered in the injured newborn brain, showing the long-standing effect of inflammation.

Uncontrolled Keywords

artificial neural networks; inflammation; optical imaging of intrinsic signals; prematurity; resting state functional connectivity; support vector machines; white matter injury

Open Access document in PolyPublie
Subjects: 1900 Génie biomédical > 1900 Génie biomédical
1900 Génie biomédical > 1901 Technologie biomédicale
Department: Département de génie électrique
Research Center: Non applicable
Funders: Canadian Institutes of Health Research—Institute of Human Development, Child and Youth Health (IHDCYH), XVe Groupe de travail Québec-Mexique 2015–2016, Québec Bio-Imaging Network, Cátedras CONACYT, Research Center of Sainte-Justine, Fonds de recherche du Québec—Santé, NSERC Discovery, CIHR Grant
Grant number: 136908
Date Deposited: 20 Oct 2021 14:15
Last Modified: 22 Oct 2021 17:05
PolyPublie URL: https://publications.polymtl.ca/4911/
Document issued by the official publisher
Journal Title: Frontiers in Neuroscience (vol. 11)
Publisher: Frontiers
Official URL: https://doi.org/10.3389/fnins.2017.00358

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