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Postmortem diffusion MRI of the entire human spinal cord at microscopic resolution

Evan Calabrese, Syed M. Adil, Gary Cofer, Christian S. Perone, Julien Cohen-Adad, Shivanand P. Lad and G. Allan Johnson

Article (2018)

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Cite this document: Calabrese, E., Adil, S. M., Cofer, G., Perone, C. S., Cohen-Adad, J., Lad, S. P. & Johnson, G. A. (2018). Postmortem diffusion MRI of the entire human spinal cord at microscopic resolution. NeuroImage: Clinical, 18, p. 963-971. doi:10.1016/j.nicl.2018.03.029
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Abstract

The human spinal cord is a central nervous system structure that plays an important role in normal motor and sensory function, and can be affected by many debilitating neurologic diseases. Due to its clinical importance, the spinal cord is frequently the subject of imaging research. Common methods for visualizing spinal cord anatomy and pathology include histology and magnetic resonance imaging (MRI), both of which have unique benefits and drawbacks. Postmortem microscopic resolution MRI of fixed specimens, sometimes referred to as magnetic resonance microscopy (MRM), combines many of the benefits inherent to both techniques. However, the elongated shape of the human spinal cord, along with hardware and scan time limitations, have restricted previous microscopic resolution MRI studies (both in vivo and ex vivo) to small sections of the cord. Here we present the first MRM dataset of the entire postmortem human spinal cord. These data include 50mum isotropic resolution anatomic image data and 100mum isotropic resolution diffusion data, made possible by a 280h long multi-segment acquisition and automated image segment composition. We demonstrate the use of these data for spinal cord lesion detection, automated volumetric gray matter segmentation, and quantitative spinal cord morphometry including estimates of cross sectional dimensions and gray matter fraction throughout the length of the cord.

Uncontrolled Keywords

Cross-Sectional Studies; Diffusion Magnetic Resonance Imaging/methods; Gray Matter/*pathology; Humans; Image Processing, Computer-Assisted/methods; *Magnetic Resonance Imaging/methods; Male; Neuroimaging/methods; Spinal Cord/*pathology; Spinal Cord Diseases/pathology; White Matter/*pathology; *Gray matter; *Human; *Magnetic resonance microscopy; *Spinal cord; *Tractography

Open Access document in PolyPublie
Subjects: 1900 Génie biomédical > 1900 Génie biomédical
1900 Génie biomédical > 1901 Technologie biomédicale
2500 Génie électrique et électronique > 2519 Microélectronique
2700 Technologie de l'information > 2708 Traitement d'images et traitement vidéo
Department: Département de génie électrique
Institut de génie biomédical
Polytechnique Montréal > Centres de recherche > Institut de génie biomédical
Research Center: Autre
Funders: National Institutes of Health
Grant number: P41 EB015897, 1S10OD010683-01
Date Deposited: 13 Jul 2021 10:11
Last Modified: 14 Jul 2021 01:20
PolyPublie URL: https://publications.polymtl.ca/4813/
Document issued by the official publisher
Journal Title: NeuroImage: Clinical (vol. 18)
Publisher: Elsevier
Official URL: https://doi.org/10.1016/j.nicl.2018.03.029

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