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Longitudinal Impact of Physical Activity on Brain Pulsatility Index and Cognition in Older Adults with Cardiovascular Risk Factors: A NIRS Study

Hanieh Mohammadi, Christine Gagnon, Thomas Vincent, Ali Kassab, Sarah Fraser, Anil Nigam, Frédéric Lesage, Louis Bherer

Article (2021)

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Abstract

Recent studies have shown that optical indices of cerebral pulsatility, including cerebral pulse amplitude, are linked to cerebrovascular health. A chronically higher cerebral pulsatility is associated with cognitive decline. Although it is widely known that regular physical activity improves cognitive functions, little is known about the association between physical activity and the optical index of cerebral pulsatility. This study assessed the impact of 12 months of regular physical activity on the changes in the optical index of cerebral pulsatility and explored its association with cognition. A total of 19 older adults (aged 59–79 years) with cardiovascular risk factors (CVRF) completed the study. Low-intensity, short-duration walking as a brief cardiovascular challenge was used to study the impact of regular physical activity on post-walking changes in cerebral pulsatility index. The participants walked on a gym track while a near-infrared spectroscopy (NIRS) device recorded hemodynamics data from the frontal and motor cortex subregions. Our data indicated that 12 months of physical activity was associated with lower global cerebral pulse amplitude, which was associated with higher cognitive scores in executive functions. Further, the global cerebral pulsatility index was reduced after short-duration walking, and this reduction was greater after 12 months of regular physical activity compared with the baseline. This may be an indication of improvement in cerebrovascular response to the cardiovascular challenge after regular physical activity. This study suggests that 12 months of physical activity may support cognitive functions through improving cerebral pulsatility in older adults with CVRF.

Uncontrolled Keywords

near-infrared spectroscopy; cerebral pulsatility; longitudinal; physical activity; cardiovascular risk factors

Subjects: 1900 Biomedical engineering > 1900 Biomedical engineering
1900 Biomedical engineering > 1901 Biomedical technology
2500 Electrical and electronic engineering > 2500 Electrical and electronic engineering
Department: Department of Electrical Engineering
Institut de génie biomédical
Funders: Canadian Institute of Health Research - Operating Grant
Grant number: 120304
PolyPublie URL: https://publications.polymtl.ca/9368/
Journal Title: Brain Sciences (vol. 11, no. 6)
Publisher: MDPI
DOI: 10.3390/brainsci11060730
Official URL: https://doi.org/10.3390/brainsci11060730
Date Deposited: 10 May 2022 09:18
Last Modified: 10 Nov 2022 15:37
Cite in APA 7: Mohammadi, H., Gagnon, C., Vincent, T., Kassab, A., Fraser, S., Nigam, A., Lesage, F., & Bherer, L. (2021). Longitudinal Impact of Physical Activity on Brain Pulsatility Index and Cognition in Older Adults with Cardiovascular Risk Factors: A NIRS Study. Brain Sciences, 11(6), 14 pages. https://doi.org/10.3390/brainsci11060730

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