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HARDI-ZOOMit protocol improves specificity to microstructural changes in presymptomatic myelopathy

René Labounek, Jan Valošek, Tomáš Horák, Alena Svátková, Petr Bednařík, Lubomír Vojtíšek, Magda Horáková, Igor Nestrašil, Christophe Lenglet, Julien Cohen-Adad, Josef Bednařík and Petr Hluštík

Article (2020)

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Diffusion magnetic resonance imaging (dMRI) proved promising in patients with non-myelopathic degenerative cervical cord compression (NMDCCC), i.e., without clinically manifested myelopathy. Aim of the study is to present a fast multi-shell HARDI-ZOOMit dMRI protocol and validate its usability to detect microstructural myelopathy in NMDCCC patients. In 7 young healthy volunteers, 13 age-comparable healthy controls, 18 patients with mild NMDCCC and 15 patients with severe NMDCCC, the protocol provided higher signal-to-noise ratio, enhanced visualization of white/gray matter structures in microstructural maps, improved dMRI metric reproducibility, preserved sensitivity (SE = 87.88%) and increased specificity (SP = 92.31%) of control-patient group differences when compared to DTI-RESOLVE protocol (SE = 87.88%, SP = 76.92%). Of the 56 tested microstructural parameters, HARDI-ZOOMit yielded significant patient-control differences in 19 parameters, whereas in DTI-RESOLVE data, differences were observed in 10 parameters, with mostly lower robustness. Novel marker the white-gray matter diffusivity gradient demonstrated the highest separation. HARDI-ZOOMit protocol detected larger number of crossing fibers (5–15% of voxels) with physiologically plausible orientations than DTI-RESOLVE protocol (0–8% of voxels). Crossings were detected in areas of dorsal horns and anterior white commissure. HARDI-ZOOMit protocol proved to be a sensitive and practical tool for clinical quantitative spinal cord imaging.

Uncontrolled Keywords

Biomedical engineering, Data acquisition, Diagnostic markers, Spinal cord diseases, Spine structure

Additional Information: Supplementary information is available for this paper at https://doi.org/10.1038/s41598-020-70297-3
Subjects: 1900 Biomedical engineering > 1900 Biomedical engineering
1900 Biomedical engineering > 1901 Biomedical technology
Department: Institut de génie biomédical
PolyPublie URL: https://publications.polymtl.ca/9289/
Journal Title: Scientific Reports (vol. 10, no. 1)
Publisher: Springer Nature
DOI: 10.1038/s41598-020-70297-3
Official URL: https://doi.org/10.1038/s41598-020-70297-3
Date Deposited: 01 Mar 2023 13:57
Last Modified: 24 Oct 2023 12:16
Cite in APA 7: Labounek, R., Valošek, J., Horák, T., Svátková, A., Bednařík, P., Vojtíšek, L., Horáková, M., Nestrašil, I., Lenglet, C., Cohen-Adad, J., Bednařík, J., & Hluštík, P. (2020). HARDI-ZOOMit protocol improves specificity to microstructural changes in presymptomatic myelopathy. Scientific Reports, 10(1), 17529 (19 pages). https://doi.org/10.1038/s41598-020-70297-3


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