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Navigation of superparamagnetic particles with a pre-magnetized high-temperature superconducting bulk in a weak background field

Alexandre Arsenault, Frédéric Sirois, Ning Li and Gilles Soulez

Article (2024)

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Abstract

Recent research has shown significant progress towards a full body magnetic drug delivery (MDD) system for use in targeted cancer treatments. Although many different MDD systems have been proposed to generate strong remote forces capable of rapidly changing directions at distances greater than 10 cm, current state-of-the-art technologies lack in force strength and/or degrees of freedom. Knowing that high temperature superconducting (HTS) bulks can achieve trapped fields an order of magnitude larger than ferromagnets, this work aims at numerically and experimentally evaluating the forces that can be produced by HTS bulks in a uniform magnetic field. We first use Hall probe measurements and finite element simulations to determine the magnetic field generated by an HTS pellet and show that both results are in good agreement. Using a combination of simulations and experiments, we then show that for a 14 x 6mm YBa₂Cu₃O₇₋z pellet magnetized at 2 T, remote forces on superparamagnetic microparticles are maximized at background fields of ∼50 mT. In addition, the direction of the magnetic forces can be flipped by changing the direction of the applied field relative to the HTS's magnetization. The HTS bulk was successfully used to navigate magnetic microparticles in a glass bifurcation mimicking the hepatic artery of the human liver. Finally, we show by simulation that a large HTS pellet magnetized at 5 T in a field of ∼250 mT can generate stronger forces with more degrees of freedom than the strongest forces achievable in current MDD technologies.

Uncontrolled Keywords

magnetic drug delivery; remote magnetic force; HTS magnetization; finite element method

Subjects: 1800 Chemical engineering > 1800 Chemical engineering
2500 Electrical and electronic engineering > 2500 Electrical and electronic engineering
Department: Department of Electrical Engineering
Funders: NSERC / CRSNG, Fonds de recherche du Québec - Nature et technologies (FRQNT), TransMedTech Institute
PolyPublie URL: https://publications.polymtl.ca/59468/
Journal Title: Superconductor Science and Technology (vol. 37, no. 11)
Publisher: IOP Publishing
DOI: 10.1088/1361-6668/ad7c8c
Official URL: https://doi.org/10.1088/1361-6668/ad7c8c
Date Deposited: 25 Oct 2024 11:39
Last Modified: 09 Feb 2025 11:05
Cite in APA 7: Arsenault, A., Sirois, F., Li, N., & Soulez, G. (2024). Navigation of superparamagnetic particles with a pre-magnetized high-temperature superconducting bulk in a weak background field. Superconductor Science and Technology, 37(11), 115008 (13 pages). https://doi.org/10.1088/1361-6668/ad7c8c

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