Eli BenDavid, Sina Ramezanian, Yaoyao Lu, Joël Rousseau, Avi Schroeder, Marc Lavertu
et Jacques P. Tremblay
Article de revue (2024)
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Abstract
Prime editing shows potential as a precision genome editing technology, as well as the potential to advance the development of next-generation nanomedicine for addressing neurological disorders. However, turning in prime editors (PEs), which are macromolecular complexes composed of CRISPR/Cas9 nickase fused with a reverse transcriptase and a prime editing guide RNA (pegRNA), to the brain remains a considerable challenge due to physiological obstacles, including the blood–brain barrier (BBB). This review article offers an up-to-date overview and perspective on the latest technologies and strategies for the precision delivery of PEs to the brain and passage through blood barriers. Furthermore, it delves into the scientific significance and possible therapeutic applications of prime editing in conditions related to neurological diseases. It is targeted at clinicians and clinical researchers working on advancing precision nanomedicine for neuropathologies.
Mots clés
neurology; gene therapy; CRISPR/Cas9; prime editing; genetic engineering; drug delivery system; nanomaterial; targeted drug delivery; personalized nanomedicine
| Renseignements supplémentaires: | Groupe de recherche: Laboratory of Biomaterials and Tissue Engineering |
|---|---|
| Sujet(s): |
1800 Génie chimique > 1800 Génie chimique 1900 Génie biomédical > 1900 Génie biomédical 1900 Génie biomédical > 1901 Technologie biomédicale |
| Département: |
Département de génie mécanique Institut de génie biomédical |
| Centre de recherche: | Autre |
| Organismes subventionnaires: | Canadian Institute of Heath Research |
| Numéro de subvention: | 185747 |
| URL de PolyPublie: | https://publications.polymtl.ca/58613/ |
| Titre de la revue: | Pharmaceuticals (vol. 17, no 6) |
| Maison d'édition: | MDPI |
| DOI: | 10.3390/ph17060763 |
| URL officielle: | https://doi.org/10.3390/ph17060763 |
| Date du dépôt: | 26 juin 2024 12:51 |
| Dernière modification: | 26 sept. 2024 12:51 |
| Citer en APA 7: | BenDavid, E., Ramezanian, S., Lu, Y., Rousseau, J., Schroeder, A., Lavertu, M., & Tremblay, J. P. (2024). Emerging perspectives on prime editor delivery to the brain. Pharmaceuticals, 17(6), 763 (42 pages). https://doi.org/10.3390/ph17060763 |
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