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Impact of stalling events on microcirculatory hemodynamics in the aged brain

Mohammad Jamshidi, Thomas Ventimiglia, Patrice Sudres, Cong Zhang, Frédéric Lesage, William D. Rooney, Daniel L. Schwartz and Andreas A. Linninger

Article (2024)

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Abstract

Objective The role of cerebral microvasculature in cognitive dysfunction can be investigated by identifying the impact of blood flow on cortical tissue oxygenation. In this paper, the impact of capillary stalls on microcirculatory characteristics such as flow and hematocrit (Ht) in the cortical angioarchitecture is studied.

Methods Using a deterministic mathematical model to simulate blood flow in a realistic mouse cortex, hemodynamics parameters, including pressure, flow, vessel diameter-adjustable hematocrit, and transit time are calculated as a function of stalling events.

Results Using a non-linear plasma skimming model, it is observed that Ht increases in the penetrating arteries from the pial vessels as a function of cortical depth. The incidence of stalling on Ht distribution along the blood network vessels shows reduction of RBCs around the tissue near occlusion sites and decreased Ht concentration downstream from the blockage points. Moreover, upstream of the occlusion, there is a noticeable increase of the Ht, leading to larger flow resistance due to higher blood viscosity. We predicted marked changes in transit time behavior due to stalls which match trends observed in mice in vivo.

Conclusions These changes to blood cell quantity and quality may be implicated in the development of Alzheimer's disease and contribute to the course of the illness.

Uncontrolled Keywords

capillary stalling, cerebral blood flow, cerebral hemodynamics, mathematical modeling, microcirculation

Department: Department of Electrical Engineering
Funders: NIH National Institute of Health, Neurological Disorders and Stroke, National Institute of Health, National Institute of Aging
Grant number: NIH NINDS 1R21NS099896, NIH NIA1R56AG066634-01
PolyPublie URL: https://publications.polymtl.ca/57337/
Journal Title: Microcirculation
Publisher: Wiley-Blackwell
DOI: 10.1111/micc.12845
Official URL: https://doi.org/10.1111/micc.12845
Date Deposited: 12 Feb 2024 09:34
Last Modified: 05 Apr 2024 23:39
Cite in APA 7: Jamshidi, M., Ventimiglia, T., Sudres, P., Zhang, C., Lesage, F., Rooney, W. D., Schwartz, D. L., & Linninger, A. A. (2024). Impact of stalling events on microcirculatory hemodynamics in the aged brain. Microcirculation, e12845 (14 pages). https://doi.org/10.1111/micc.12845

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