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Multifaceted ligand design facilitates chemical- or peptide-mediated linking of hollow gold nanoshells with tuned interparticle distance, interference and cytotoxicities

Yu-Chen Wang, Gabriel Théberge-Julien, Jean-Claude Tardif, Éric Rhéaume, Frédéric Lesage and Ashok Kakkar

Article (2022)

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Abstract

We report a versatile methodology to covalently link hollow gold nanoshells (HAuNS) through modular design of multi-tasking ligands and bio-adaptable chemistry. The biocompatible ligand composition includes strategically placed two polyethylene glycol (PEG) chains, protected thiol-terminated tetraethylene glycol, and a reactive functional group, on a core. HAuNS are functionalized through an in situ one-pot deprotection/thiol-Au binding. The ligand-functionalized HAuNS with surface exposed COOH or OH entities are employed in constructing linked-HAuNS conjugated through a short chemical- or a longer bio-spacer (GPLGVRG peptide), in which (i) the length of the PEG chains plays an important role in minimizing oligomerization during covalent linking of HAuNS; (ii) inter-particle distance and interference of HAuNS surface plasmon resonance are regulated through chemical/peptide junctions, with UV-Vis-NIR absorption maxima red-shifted in chem-linked HAuNS; and (iii) chem-linked HAuNS-to-monomer conversion leads to amplification of the photoacoustic signal. Ligand stabilized monomeric and linked-HAuNS are less cytotoxic than citrate protected HAuNS. The synthetic tools and facile chemistry described here provide opportunities in designing linked metal nanoparticles for broad applications in biology.

Subjects: 1800 Chemical engineering > 1800 Chemical engineering
Department: Department of Electrical Engineering
Funders: Canadian Institutes of Health Research, Natural Sciences and Engineering Research Council of Canada, Fonds de recherche du Québec – Nature et technologies
PolyPublie URL: https://publications.polymtl.ca/54337/
Journal Title: Materials advances (vol. 3, no. 19)
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2ma00624c
Official URL: https://doi.org/10.1039/d2ma00624c
Date Deposited: 02 Nov 2023 14:14
Last Modified: 04 Nov 2023 22:26
Cite in APA 7: Wang, Y.-C., Théberge-Julien, G., Tardif, J.-C., Rhéaume, É., Lesage, F., & Kakkar, A. (2022). Multifaceted ligand design facilitates chemical- or peptide-mediated linking of hollow gold nanoshells with tuned interparticle distance, interference and cytotoxicities. Materials advances, 3(19), 7272-7284. https://doi.org/10.1039/d2ma00624c

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