Yu-Chen Wang, Gabriel Théberge-Julien, Jean-Claude Tardif, Éric Rhéaume, Frédéric Lesage and Ashok Kakkar
Article (2022)
Open Acess document in PolyPublie and at official publisher |
|
Open Access to the full text of this document Published Version Terms of Use: Creative Commons Attribution Non-commercial Download (2MB) |
Abstract
We report a versatile methodology to covalently link hollow gold nanoshells (HAuNS) through modular design of multi-tasking ligands and bio-adaptable chemistry. The biocompatible ligand composition includes strategically placed two polyethylene glycol (PEG) chains, protected thiol-terminated tetraethylene glycol, and a reactive functional group, on a core. HAuNS are functionalized through an in situ one-pot deprotection/thiol-Au binding. The ligand-functionalized HAuNS with surface exposed COOH or OH entities are employed in constructing linked-HAuNS conjugated through a short chemical- or a longer bio-spacer (GPLGVRG peptide), in which (i) the length of the PEG chains plays an important role in minimizing oligomerization during covalent linking of HAuNS; (ii) inter-particle distance and interference of HAuNS surface plasmon resonance are regulated through chemical/peptide junctions, with UV-Vis-NIR absorption maxima red-shifted in chem-linked HAuNS; and (iii) chem-linked HAuNS-to-monomer conversion leads to amplification of the photoacoustic signal. Ligand stabilized monomeric and linked-HAuNS are less cytotoxic than citrate protected HAuNS. The synthetic tools and facile chemistry described here provide opportunities in designing linked metal nanoparticles for broad applications in biology.
Subjects: | 1800 Chemical engineering > 1800 Chemical engineering |
---|---|
Department: | Department of Electrical Engineering |
Funders: | Canadian Institutes of Health Research, Natural Sciences and Engineering Research Council of Canada, Fonds de recherche du Québec – Nature et technologies |
PolyPublie URL: | https://publications.polymtl.ca/54337/ |
Journal Title: | Materials advances (vol. 3, no. 19) |
Publisher: | Royal Society of Chemistry |
DOI: | 10.1039/d2ma00624c |
Official URL: | https://doi.org/10.1039/d2ma00624c |
Date Deposited: | 02 Nov 2023 14:14 |
Last Modified: | 26 Sep 2024 11:36 |
Cite in APA 7: | Wang, Y.-C., Théberge-Julien, G., Tardif, J.-C., Rhéaume, É., Lesage, F., & Kakkar, A. (2022). Multifaceted ligand design facilitates chemical- or peptide-mediated linking of hollow gold nanoshells with tuned interparticle distance, interference and cytotoxicities. Materials advances, 3(19), 7272-7284. https://doi.org/10.1039/d2ma00624c |
---|---|
Statistics
Total downloads
Downloads per month in the last year
Origin of downloads
Dimensions