<  Back to the Polytechnique Montréal portal

Compromised microvascular oxygen delivery increases brain tissue vulnerability with age

Mohammad Moeini, Xuecong Lu, Pramod K. Avti, Rafat Damseh, Samuel Bélanger, Frédéric Picard, David Boas, Ashok Kakkar and Frédéric Lesage

Article (2018)

Published Version
Terms of Use: Creative Commons Attribution .
Download (1MB)
Cite this document: Moeini, M., Lu, X., Avti, P. K., Damseh, R., Bélanger, S., Picard, F., ... Lesage, F. (2018). Compromised microvascular oxygen delivery increases brain tissue vulnerability with age. Scientific Reports, 8. doi:10.1038/s41598-018-26543-w
Show abstract Hide abstract


Despite the possible role of impaired cerebral tissue oxygenation in age-related cognition decline, much is still unknown about the changes in brain tissue pO2 with age. Using a detailed investigation of the age-related changes in cerebral tissue oxygenation in the barrel cortex of healthy, awake aged mice, we demonstrate decreased arteriolar and tissue pO2 with age. These changes are exacerbated after middle-age. We further uncovered evidence of the presence of hypoxic micro-pockets in the cortex of awake old mice. Our data suggests that from young to middle-age, a well-regulated capillary oxygen supply maintains the oxygen availability in cerebral tissue, despite decreased tissue pO2 next to arterioles. After middle-age, due to decreased hematocrit, reduced capillary density and higher capillary transit time heterogeneity, the capillary network fails to compensate for larger decreases in arterial pO2. The substantial decrease in brain tissue pO2, and the presence of hypoxic micro-pockets after middle-age are of significant importance, as these factors may be related to cognitive decline in elderly people.

Uncontrolled Keywords

Aging/*metabolism; Animals; Arterioles/*metabolism; Brain/*blood supply; Cerebrovascular Circulation; Mice; Oxygen/*metabolism; Venules/*metabolism

Open Access document in PolyPublie
Subjects: 1900 Génie biomédical > 1900 Génie biomédical
1900 Génie biomédical > 1901 Technologie biomédicale
Department: Institut de génie biomédical
Funders: Canadian Institutes of Health Research, CRSNG/NSERC, MÉDITIS, Fonds de Recherche du Québec– Nature et Technologies
Grant number: CIHR 299166, NSERC 239876-2011, NSERC 06080-2017
Date Deposited: 13 Jan 2022 13:35
Last Modified: 14 Jan 2022 01:20
PolyPublie URL: https://publications.polymtl.ca/5031/
Document issued by the official publisher
Journal Title: Scientific Reports (vol. 8)
Publisher: Nature
Official URL: https://doi.org/10.1038/s41598-018-26543-w


Total downloads

Downloads per month in the last year

Origin of downloads


Repository Staff Only