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Compromised microvascular oxygen delivery increases brain tissue vulnerability with age

Mohammad Moeini, Xuecong Lu, Pramod K. Avti, Rafat Damseh, Samuel Bélanger, Frédéric Picard, David Boas, Ashok Kakkar et Frédéric Lesage

Article de revue (2018)

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Abstract

Despite the possible role of impaired cerebral tissue oxygenation in age-related cognition decline, much is still unknown about the changes in brain tissue pO2 with age. Using a detailed investigation of the age-related changes in cerebral tissue oxygenation in the barrel cortex of healthy, awake aged mice, we demonstrate decreased arteriolar and tissue pO2 with age. These changes are exacerbated after middle-age. We further uncovered evidence of the presence of hypoxic micro-pockets in the cortex of awake old mice. Our data suggests that from young to middle-age, a well-regulated capillary oxygen supply maintains the oxygen availability in cerebral tissue, despite decreased tissue pO2 next to arterioles. After middle-age, due to decreased hematocrit, reduced capillary density and higher capillary transit time heterogeneity, the capillary network fails to compensate for larger decreases in arterial pO2. The substantial decrease in brain tissue pO2, and the presence of hypoxic micro-pockets after middle-age are of significant importance, as these factors may be related to cognitive decline in elderly people.

Mots clés

Aging/*metabolism; Animals; Arterioles/*metabolism; Brain/*blood supply; Cerebrovascular Circulation; Mice; Oxygen/*metabolism; Venules/*metabolism

Sujet(s): 1900 Génie biomédical > 1900 Génie biomédical
1900 Génie biomédical > 1901 Technologie biomédicale
Département: Institut de génie biomédical
Organismes subventionnaires: Canadian Institutes of Health Research, CRSNG/NSERC, MÉDITIS, Fonds de Recherche du Québec– Nature et Technologies
Numéro de subvention: CIHR 299166, NSERC 239876-2011, NSERC 06080-2017
URL de PolyPublie: https://publications.polymtl.ca/5031/
Titre de la revue: Scientific Reports (vol. 8, no 1)
Maison d'édition: Nature
DOI: 10.1038/s41598-018-26543-w
URL officielle: https://doi.org/10.1038/s41598-018-26543-w
Date du dépôt: 13 janv. 2022 13:35
Dernière modification: 30 sept. 2023 16:51
Citer en APA 7: Moeini, M., Lu, X., Avti, P. K., Damseh, R., Bélanger, S., Picard, F., Boas, D., Kakkar, A., & Lesage, F. (2018). Compromised microvascular oxygen delivery increases brain tissue vulnerability with age. Scientific Reports, 8(1), 8219 (17 pages). https://doi.org/10.1038/s41598-018-26543-w

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