<  Back to the Polytechnique Montréal portal

Metabolic therapies inhibit tumor growth in vivo and in silico

Jorgelindo da Veiga Moreira, Minoo Hamraz, Mohammad Abolhassani, Laurent Schwartz, Mario Jolicoeur and Sabine Peres

Article (2019)

[img]
Preview
Published Version
Terms of Use: Creative Commons Attribution .
Download (1MB)
Cite this document: da Veiga Moreira, J., Hamraz, M., Abolhassani, M., Schwartz, L., Jolicoeur, M. & Peres, S. (2019). Metabolic therapies inhibit tumor growth in vivo and in silico. Scientific Reports, 9(1). doi:10.1038/s41598-019-39109-1
Show abstract Hide abstract

Abstract

In the recent years, cancer research succeeded with sensitive detection methods, targeted drug delivery systems, and the identification of a large set of genes differently expressed. However, although most therapies are still based on antimitotic agents, which are causing wide secondary effects, there is an increasing interest for metabolic therapies that can minimize side effects. In the early 20(th) century, Otto Warburg revealed that cancer cells rely on the cytoplasmic fermentation of glucose to lactic acid for energy synthesis (called "Warburg effect"). Our investigations aim to reverse this effect in reprogramming cancer cells' metabolism. In this work, we present a metabolic therapy specifically targeting the activity of specific enzymes of central carbon metabolism, combining the METABLOC bi-therapeutic drugs combination (Alpha Lipoic Acid and Hydroxycitrate) to Metformin and Diclofenac, for treating tumors implanted in mice. Furthermore, a dynamic metabolic model describing central carbon metabolism as well as fluxes targeted by the drugs allowed to simulate tumors progression in both treated and non-treated mice, in addition to draw hypotheses on the effects of the drugs on tumor cells metabolism. Our model predicts metabolic therapies-induced reversed Warburg effect on tumor cells.

Open Access document in PolyPublie
Subjects: 1800 Génie chimique > 1800 Génie chimique
1800 Génie chimique > 1802 Génie biochimique
Department: Département de génie chimique
Research Center: Non applicable
Date Deposited: 20 Jul 2021 13:00
Last Modified: 21 Jul 2021 01:20
PolyPublie URL: https://publications.polymtl.ca/4836/
Document issued by the official publisher
Journal Title: Scientific Reports (vol. 9, no. 1)
Publisher: Springer Nature
Official URL: https://doi.org/10.1038/s41598-019-39109-1

Statistics

Total downloads

Downloads per month in the last year

Origin of downloads

Dimensions

Repository Staff Only