<  Back to the Polytechnique Montréal portal

Gray matter alterations in early and late relapsing-remitting multiple sclerosis evaluated with synthetic quantitative magnetic resonance imaging

Christina Andica, Akifumi Hagiwara, Koji Kamagata, Kazumasa Yokoyama, Keigo Shimoji, Asami Saito, Yuki Takenaka, Misaki Nakazawa, Masaaki Hori, Julien Cohen-Adad, Mariko Yoshida Takemura, Nobutaka Hattori and Shigeki Aoki

Article (2019)

[img]
Preview
Published Version
Terms of Use: Creative Commons Attribution.
Download (1MB)
[img]
Preview
Supplemental Material
Terms of Use: Creative Commons Attribution.
Download (1MB)
Cite this document: Andica, C., Hagiwara, A., Kamagata, K., Yokoyama, K., Shimoji, K., Saito, A., ... Aoki, S. (2019). Gray matter alterations in early and late relapsing-remitting multiple sclerosis evaluated with synthetic quantitative magnetic resonance imaging. Scientific Reports, 9(1), p. 8147-8156. doi:10.1038/s41598-019-44615-3
Show abstract Hide abstract

Abstract

Abstract: Extensive gray matter (GM) involvement has been demonstrated in multiple sclerosis (MS) patients. This study was aimed to identify GM alterations in relapsing-remitting MS (RRMS) patients using synthetic quantitative MRI (qMRI). We assessed myelin volume fraction (MVF) in each voxel on the basis of R1 and R2 relaxation rates and proton density in 14 early and 28 late (disease duration </=5 and >5 years, respectively) RRMS patients, and 15 healthy controls (HCs). The MVF and myelin volumes of GM (GM-MyVol) were compared between groups using GM-based spatial statistics (GBSS) and the Kruskal-Wallis test, respectively. Correlations between MVF or GM-MyVol and disease duration or expanded disability status scale were also evaluated. RRMS patients showed a lower MVF than HCs, predominantly in the limbic and para-limbic areas, with more extensive areas noted in late RRMS patients. Late-RRMS patients had the smallest GM-MyVol (20.44 mL; early RRMS, 22.77 mL; HCs, 23.36 mL). Furthermore, the GM-MyVol in the RRMS group was inversely correlated with disease duration (r = -0.43, p = 0.005). In conclusion, the MVF and MyVol obtained by synthetic qMRI can be used to evaluate GM differences in RRMS patients.

Open Access document in PolyPublie
Subjects: 1900 Génie biomédical > 1900 Génie biomédical
1900 Génie biomédical > 1901 Technologie biomédicale
9000 Sciences de la santé > 9000 Sciences de la santé
Department: Département de génie électrique
Institut de génie biomédical
Polytechnique Montréal > Centres de recherche > Institut de génie biomédical
Research Center: Non applicable
Funders: Japan Society for the Promotion of Science (JSPS) KAKENHI, Japan Society for the Promotion of Science (JSPS) - Grant-in-Aid for Scientific Research on Innovative Areas, resource and technical support platforms for promoting research ‘Advanced Bioimaging Support’, Japan Agency for Medical Research and Development (AMED) - Program for Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/MINDS), Council for Science, Technology and Innovation (Cabinet Office, Government of Japan) - Impulsing Paradigm Change through Disruptive Technologies (ImPACT) Program
Grant number: 16K19852, 16K10327, JP16H06280
Date Deposited: 10 Mar 2021 12:05
Last Modified: 11 Mar 2021 01:20
PolyPublie URL: https://publications.polymtl.ca/4749/
Document issued by the official publisher
Journal Title: Scientific Reports (vol. 9, no. 1)
Publisher: Springer Nature
Official URL: https://doi.org/10.1038/s41598-019-44615-3

Statistics

Total downloads

Downloads per month in the last year

Origin of downloads

Dimensions

Repository Staff Only