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Gray matter alterations in early and late relapsing-remitting multiple sclerosis evaluated with synthetic quantitative magnetic resonance imaging

Christina Andica, Akifumi Hagiwara, Koji Kamagata, Kazumasa Yokoyama, Keigo Shimoji, Asami Saito, Yuki Takenaka, Misaki Nakazawa, Masaaki Hori, Julien Cohen-Adad, Mariko Yoshida Takemura, Nobutaka Hattori and Shigeki Aoki

Article (2019)

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Abstract

Abstract: Extensive gray matter (GM) involvement has been demonstrated in multiple sclerosis (MS) patients. This study was aimed to identify GM alterations in relapsing-remitting MS (RRMS) patients using synthetic quantitative MRI (qMRI). We assessed myelin volume fraction (MVF) in each voxel on the basis of R1 and R2 relaxation rates and proton density in 14 early and 28 late (disease duration </=5 and >5 years, respectively) RRMS patients, and 15 healthy controls (HCs). The MVF and myelin volumes of GM (GM-MyVol) were compared between groups using GM-based spatial statistics (GBSS) and the Kruskal-Wallis test, respectively. Correlations between MVF or GM-MyVol and disease duration or expanded disability status scale were also evaluated. RRMS patients showed a lower MVF than HCs, predominantly in the limbic and para-limbic areas, with more extensive areas noted in late RRMS patients. Late-RRMS patients had the smallest GM-MyVol (20.44 mL; early RRMS, 22.77 mL; HCs, 23.36 mL). Furthermore, the GM-MyVol in the RRMS group was inversely correlated with disease duration (r = -0.43, p = 0.005). In conclusion, the MVF and MyVol obtained by synthetic qMRI can be used to evaluate GM differences in RRMS patients.

Subjects: 1900 Biomedical engineering > 1900 Biomedical engineering
1900 Biomedical engineering > 1901 Biomedical technology
9000 Health sciences > 9000 Health sciences
Department: Department of Electrical Engineering
Institut de génie biomédical
Funders: Japan Society for the Promotion of Science (JSPS) KAKENHI, Japan Society for the Promotion of Science (JSPS) - Grant-in-Aid for Scientific Research on Innovative Areas, resource and technical support platforms for promoting research ‘Advanced Bioimaging Support’, Japan Agency for Medical Research and Development (AMED) - Program for Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/MINDS), Council for Science, Technology and Innovation (Cabinet Office, Government of Japan) - Impulsing Paradigm Change through Disruptive Technologies (ImPACT) Program
Grant number: 16K19852, 16K10327, JP16H06280
PolyPublie URL: https://publications.polymtl.ca/4749/
Journal Title: Scientific Reports (vol. 9, no. 1)
Publisher: Springer Nature
DOI: 10.1038/s41598-019-44615-3
Official URL: https://doi.org/10.1038/s41598-019-44615-3
Date Deposited: 10 Mar 2021 12:05
Last Modified: 20 Apr 2024 04:45
Cite in APA 7: Andica, C., Hagiwara, A., Kamagata, K., Yokoyama, K., Shimoji, K., Saito, A., Takenaka, Y., Nakazawa, M., Hori, M., Cohen-Adad, J., Takemura, M. Y., Hattori, N., & Aoki, S. (2019). Gray matter alterations in early and late relapsing-remitting multiple sclerosis evaluated with synthetic quantitative magnetic resonance imaging. Scientific Reports, 9(1), 8147-8156. https://doi.org/10.1038/s41598-019-44615-3

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