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ZOOM or non-ZOOM? Assessing spinal cord diffusion tensor imaging protocols for multi-centre studies

Rebecca S. Samson, Simon Lévy, Torben Schneider, Alex K. Smith, Seth A. Smith, Julien Cohen-Adad and Claudia Angela M. Gandini Wheeler-Kingshott

Article (2016)

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The purpose of this study was to develop and evaluate two spinal cord (SC) diffusion tensor imaging (DTI) protocols, implemented at multiple sites (using scanners from two different manufacturers), one available on any clinical scanner, and one using more advanced options currently available in the research setting, and to use an automated processing method for unbiased quantification. DTI parameters are sensitive to changes in the diseased SC. However, imaging the cord can be technically challenging due to various factors including its small size, patient-related and physiological motion, and field inhomogeneities. Rapid acquisition sequences such as Echo Planar Imaging (EPI) are desirable but may suffer from image distortions. We present a multi-centre comparison of two acquisition protocols implemented on scanners from two different vendors (Siemens and Philips), one using a reduced field-of-view (rFOV) EPI sequence, and one only using options available on standard clinical scanners such as outer volume suppression (OVS). Automatic analysis was performed with the Spinal Cord Toolbox for unbiased and reproducible quantification of DTI metrics in the white matter. Images acquired using the rFOV sequence appear less distorted than those acquired using OVS alone. SC DTI parameter values obtained using both sequences at all sites were consistent with previous measurements made at 3T. For the same scanner manufacturer, DTI parameter inter-site SDs were smaller for the rFOV sequence compared to the OVS sequence. The higher inter-site reproducibility (for the same manufacturer and acquisition details, i.e. ZOOM data acquired at the two Philips sites) of rFOV compared to the OVS sequence supports the idea that making research options such as rFOV more widely available would improve accuracy of measurements obtained in multi-centre clinical trials. Future multi-centre studies should also aim to match the rFOV technique and signal-to-noise ratios in all sequences from different manufacturers/sites in order to avoid any bias in measured DTI parameters and ensure similar sensitivity to pathological changes.

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Subjects: 1900 Biomedical engineering > 1900 Biomedical engineering
1900 Biomedical engineering > 1901 Biomedical technology
9000 Health sciences > 9000 Health sciences
Department: Institut de génie biomédical
Funders: International Spinal Research Trust, Wings for Life, Multiple Sclerosis Society UK, Department of Health's NIHR Biomedical Research Centres funding scheme (UK), Engineering and Physical Sciences Research Council (EPSRC), Fonds de recherche du Québec--Santé (FRQS), Fonds de recherche du Québec--Nature et technologies (FRQNT), CRSNG, Réseau de bio-imagerie du Québec (RBIQ), National Institute of Neurological Disorders and Strokes (NINDS)
Grant number: IMG007, 892, EP/I027084/1, 28826, 2015-PR-182754, 435897-2013, NIH/NINDS 5R21NS087465-02
PolyPublie URL: https://publications.polymtl.ca/3517/
Journal Title: PLOS One (vol. 11, no. 5)
Publisher: PLOS
DOI: 10.1371/journal.pone.0155557
Official URL: https://doi.org/10.1371/journal.pone.0155557
Date Deposited: 05 Dec 2018 16:53
Last Modified: 24 May 2023 12:34
Cite in APA 7: Samson, R. S., Lévy, S., Schneider, T., Smith, A. K., Smith, S. A., Cohen-Adad, J., & Wheeler-Kingshott, C. A. M. G. (2016). ZOOM or non-ZOOM? Assessing spinal cord diffusion tensor imaging protocols for multi-centre studies. PLOS One, 11(5), 1-14. https://doi.org/10.1371/journal.pone.0155557


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