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Fabricating water dispersible superparamagnetic iron oxide nanoparticles for biomedical applications through ligand exchange and direct conjugation

Tina Lam, Pramod K. Avti, Philippe Pouliot, Foued Maafi, Jean-Claude Tardif, Éric Rhéaume, Frédéric Lesage and Ashok Kakkar

Article (2016)

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Cite this document: Lam, T., Avti, P. K., Pouliot, P., Maafi, F., Tardif, J.-C., Rhéaume, É., ... Kakkar, A. (2016). Fabricating water dispersible superparamagnetic iron oxide nanoparticles for biomedical applications through ligand exchange and direct conjugation. Nanomaterials, 6(6), p. 1-15. doi:10.3390/nano6060100
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Abstract

Stable superparamagnetic iron oxide nanoparticles (SPIONs), which can be easily dispersed in an aqueous medium and exhibit high magnetic relaxivities, are ideal candidates for biomedical applications including contrast agents for magnetic resonance imaging. We describe a versatile methodology to render water dispersibility to SPIONs using tetraethylene glycol (TEG)-based phosphonate ligands, which are easily introduced onto SPIONs by either a ligand exchange process of surface-anchored oleic-acid (OA) molecules or via direct conjugation. Both protocols confer good colloidal stability to SPIONs at different NaCl concentrations. A detailed characterization of functionalized SPIONs suggests that the ligand exchange method leads to nanoparticles with better magnetic properties but higher toxicity and cell death, than the direct conjugation methodology.

Uncontrolled Keywords

superparamagnetic iron oxide nanoparticles; nanoparticle ligand functionalization; contrast agents; magnetic resonance imaging; cell internalization

Open Access document in PolyPublie
Subjects: 1900 Génie biomédical > 1900 Génie biomédical
3100 Physique > 3113 Biophysique
Department: Département de génie électrique
Research Center: Non applicable
Funders: CRSNG, Fonds de recherche du Québec--Nature et technologies, Center for Self-assembled Chemical Structures
Date Deposited: 09 Jan 2019 12:49
Last Modified: 10 Jan 2019 01:20
PolyPublie URL: https://publications.polymtl.ca/3512/
Document issued by the official publisher
Journal Title: Nanomaterials (vol. 6, no. 6)
Publisher: MDPI
Official URL: https://doi.org/10.3390/nano6060100

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