Tina Lam, Pramod K. Avti, Philippe Pouliot, Foued Maafi, Jean-Claude Tardif, Éric Rhéaume, Frédéric Lesage et Ashok Kakkar
Article de revue (2016)
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Libre accès au plein texte de ce document Version officielle de l'éditeur Conditions d'utilisation: Creative Commons: Attribution (CC BY) Télécharger (407kB) |
Abstract
Stable superparamagnetic iron oxide nanoparticles (SPIONs), which can be easily dispersed in an aqueous medium and exhibit high magnetic relaxivities, are ideal candidates for biomedical applications including contrast agents for magnetic resonance imaging. We describe a versatile methodology to render water dispersibility to SPIONs using tetraethylene glycol (TEG)-based phosphonate ligands, which are easily introduced onto SPIONs by either a ligand exchange process of surface-anchored oleic-acid (OA) molecules or via direct conjugation. Both protocols confer good colloidal stability to SPIONs at different NaCl concentrations. A detailed characterization of functionalized SPIONs suggests that the ligand exchange method leads to nanoparticles with better magnetic properties but higher toxicity and cell death, than the direct conjugation methodology.
Mots clés
superparamagnetic iron oxide nanoparticles; nanoparticle ligand functionalization; contrast agents; magnetic resonance imaging; cell internalization
Sujet(s): |
1900 Génie biomédical > 1900 Génie biomédical 3100 Physique > 3113 Biophysique |
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Département: | Département de génie électrique |
Organismes subventionnaires: | CRSNG, Fonds de recherche du Québec--Nature et technologies, Center for Self-assembled Chemical Structures |
URL de PolyPublie: | https://publications.polymtl.ca/3512/ |
Titre de la revue: | Nanomaterials (vol. 6, no 6) |
Maison d'édition: | MDPI |
DOI: | 10.3390/nano6060100 |
URL officielle: | https://doi.org/10.3390/nano6060100 |
Date du dépôt: | 09 janv. 2019 12:49 |
Dernière modification: | 27 sept. 2024 22:23 |
Citer en APA 7: | Lam, T., Avti, P. K., Pouliot, P., Maafi, F., Tardif, J.-C., Rhéaume, É., Lesage, F., & Kakkar, A. (2016). Fabricating water dispersible superparamagnetic iron oxide nanoparticles for biomedical applications through ligand exchange and direct conjugation. Nanomaterials, 6(6), 1-15. https://doi.org/10.3390/nano6060100 |
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