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Lucien WeissDepartment of Engineering Physics
Profile in the Directory of Experts of Polytechnique Montréal
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Andrews, R., Fu, B., Toomey, C. E., Breiter, J. C., Lachica, J., Beckwith, J. S., Tian, R., Brock, E. E., Needham, L.-M., Chant, G. J., Loiseau, C., Deconfin, A., Baspin, K., Popovic, R., Evans, J. R., Goh, Y., Kurt, B., Senicar, L., Edmonds, M. J., ... Lee, S. F. (2025). Large-scale visualization of α-synuclein oligomers in Parkinson's disease brain tissue. Nature Biomedical Engineering, -. External link
Allen, D., Weiss, L., Saguy, A., Rosenberg, M., Iancu, O., Matalon, O., Lee, C., Beider, K., Nagler, A., Shechtman, Y., & Hendel, A. (2022). High-throughput Imaging of CRISPR- and Recombinant Adeno-associated Virus-induced DNA Damage Response in Human Hematopoietic Stem and Progenitor Cells. Crispr Journal, 5(1), 80-94. External link
Adir, O., Albalak, M. R., Abel, R., Weiss, L., Chen, G., Gruber, A., Staufer, O., Kurman, Y., Kaminer, I., Shklover, J., Shainsky-Roitman, J., Platzman, I., Gepstein, L., Shechtman, Y., Horwitz, B. A., & Schroeder, A. (2022). Synthetic cells with self-activating optogenetic proteins communicate with natural cells. Nature Communications, 13(1), 13 pages. External link
Berne, C., Marsan-Loyer, C., Weiss, L., Brun, Y., Danovitch, D., Gendron, D., & Ecoffey, S. (2025). Sticking to Green: Sustainable Solutions for Next-Generation Microelectronic Packaging with Plant-Derived and Bacterial Adhesives. ACS Sustainable Chemistry & Engineering, 13(47), 20331-20348. External link
Badalamenti, J. P., Weiss, L., Buckno, C. J., Richard, T. L., Weiss, P. S., & Cirino, P. C. (2007). Synthetic sports: a bacterial relay race. IET Synthetic Biology, 1(1), 61-63. External link
Calderon, C. P., Weiss, L., & Moerner, W. E. (2014). Robust hypothesis tests for detecting statistical evidence of two-dimensional and three-dimensional interactions in single-molecule measurements. Phys Rev E Stat Nonlin Soft Matter Phys, 89(5), 052705. External link
Cohen-Karni, T., Timko, B. P., Weiss, L., & Lieber, C. M. (2009). Flexible electrical recording from cells using nanowire transistor arrays. Proceedings of the National Academy of Sciences of the United States of America, 106(18), 7309-7313. External link
Fu, B., Jones, C. L., Heraghty, D., Yang, S., O'Brien-Ball, C., Junghans, V., Yang, H., Klenerman, D., P. J. Knowles, T., Weiss, L., Fernandes, R. A., & Lee, S. F. (2026). Patch deconvolution for Fourier light-field microscopy. Biophysical Journal, 125(5), 1305-1314. External link
Fu, B., Brock, E. E., Andrews, R., Breiter, J. C., Tian, R., Toomey, C. E., Lachica, J., Lashley, T., Ryten, M., Wood, N. W., Vendruscolo, M., Gandhi, S., Weiss, L., Beckwith, J. S., & Lee, S. F. (2024). RASP: Optimal Single Puncta Detection in Complex Cellular Backgrounds. Journal of Physical Chemistry B, 128(15), 3585-3597. External link
Ferdman, B., Nehme, E., Weiss, L., Orange, R., Alalouf, O., & Shechtman, Y. (2020). VIPR: vectorial implementation of phase retrieval for fast and accurate microscopic pixel-wise pupil estimation. Optics Express, 28(7), 10179-10198. External link
Ferdman, B., Weiss, L., Alalouf, O., Haimovich, Y., & Shechtman, Y. (2018). Ultrasensitive Refractometry via Supercritical Angle Fluorescence. ACS Nano, 12(12), 11892-11898. External link
Gordon-Soffer, R., Weiss, L., Eshel, R., Ferdman, B., Nehme, E., Bercovici, M., & Shechtman, Y. (2020). Microscopic scan-free surface profiling over extended axial ranges by point-spread-function engineering. Science Advances, 6(44). External link
Granik, N., Weiss, L., Nehme, E., Levin, M., Chein, M., Perlson, E., Roichman, Y., & Shechtman, Y. (2019). Single-Particle Diffusion Characterization by Deep Learning. Biophysical Journal, 117(2), 185-192. External link
Hershko, E., Weiss, L., Michaeli, T., & Shechtman, Y. (2019). Multicolor localization microscopy and point-spread-function engineering by deep learning. Optics Express, 27(5), 6158-6183. External link
Isasmendi, J., Castrillo Fernandez, M., Weiss, L., Trouillon, R., & Santato, C. (2025). Sepia Melanin Bio-Inks on Paper-Based Laser-Induced Graphenic Electrodes for Neurotransmitter Detection. Meeting abstracts/Meeting abstracts (Electrochemical Society. CD-ROM), MA2025-01(60), 2885 (1 page). External link
Losa, J., Simon, F., Linnik, D., Kaya, S. G., Stuart, M. C. A., Stetsenko, A., de Boer, R., Ho, F. Y., Incarnato, D., Stevens, J. A., van Eck, J., Fraaije, M. W., Weiss, L., van Teeffelen, S., Abeln, S., Guskov, A., Marrink, S.-J., Poolman, B., & Heinemann, M. (2025). Data for: Condition-dependent, amorphous protein agglomerates control cytoplasmic rheology [Dataset]. External link
Mutzafi, M., Shechtman, Y., Dicker, O., Weiss, L., Eldar, Y. C., Moerner, W. E., & Segev, M. (2017, May). Experimental Demonstration of Sparsity-Based Single-Shot Fluorescence Imaging at Sub-wavelength Resolution [Paper]. CLEO: Applications and Technology (CLEO_AT 2017), San Jose, CA, United states. External link
Milenkovic, L., Weiss, L., Yoon, J., Roth, T. L., Su, Y.R. S., Sahl, S. J., Scott, M. P., & Moerner, W. E. (2015). Single-molecule imaging of Hedgehog pathway protein Smoothened in primary cilia reveals binding events regulated by Patched1. Proceedings of the National Academy of Sciences, 112(27), 8320-5. External link
Naor, T., Nogin, Y., Nehme, E., Ferdman, B., Weiss, L., Alalouf, O., & Shechtman, Y. (2022). Quantifying cell cycle dependent chromatin dynamics during interphase by live 3D tracking. iScience, 25(5), 18 pages. External link
Nehme, E., Ferdman, B., Weiss, L., Naor, T., Freedman, D., Michaeli, T., & Shechtman, Y. (2021). Learning Optimal Wavefront Shaping for Multi-Channel Imaging. IEEE Transactions on Pattern Analysis and Machine Intelligence, 43(7), 2179-2192. External link
Nehme, E., Freedman, D., Gordon, R., Ferdman, B., Weiss, L., Alalouf, O., Naor, T., Orange, R., Michaeli, T., & Shechtman, Y. (2020). DeepSTORM3D: dense 3D localization microscopy and PSF design by deep learning. Nature Methods, 17(7), 734-740. External link
Nehme, E., Weiss, L., Michaeli, T., & Shechtman, Y. (2018). Deep-STORM: super-resolution single-molecule microscopy by deep learning. Optica, 5(4), 458-464. External link
Orange-Kedem, R., Nehme, E., Weiss, L., Ferdman, B., Alalouf, O., Opatovski, N., & Shechtman, Y. (2021). 3D printable diffractive optical elements by liquid immersion. Nature Communications, 12(1), 3067-3067. External link
Opatovski, N., Shalev Ezra, Y., Weiss, L., Ferdman, B., Orange-Kedem, R., & Shechtman, Y. (2021). Multiplexed PSF Engineering for Three-Dimensional Multicolor Particle Tracking. Nano Letters, 21(13), 5888-5895. External link
Simon, F. C. P., Ramadier, G., Fonquernie, I., Zsok, J., Patskovsky, S., Meunier, M., Boudoux, C., Dultz, E., & Weiss, L. (2026). Detecting directed motion and confinement in single-particle trajectories using hidden variables. eLife, 13, 26 pages. External link
Shalev Ezra, Y., Saguy, A., Weiss, L., Alalouf, O., Gustavsson, A.-K., & Shechtman, Y. (2026). BPS2026 – High-throughput, high-resolution visualization of DNA repair in live Saccharomyces cerevisiae reveals chromatin reconfiguration following SSBs and DSBs. [Presentation]. Biophysical Journal, 125(4), 62a-62a. Presented at 70th Annual Meeting of the Biophysical Society, San Francisco, CA, USA. External link
Simon, F. C. P., Ramadier, G., Zsok, J., Patskovsky, S., Dultz, E., Weiss, L., Ramadier, G., Zsok, J., & Dultz, E. (2026). Dataset used for the aTrack article [Dataset]. External link
Sedov, E., Koren, E., Chopra, S., Ankawa, R., Yosefzon, Y., Yusupova, M., Weiss, L., Mahly, A., Soffer, A., Feldman, A., Luxenburg, C., Shechtman, Y., & Fuchs, Y. (2025). Author Correction: THY1-mediated mechanisms converge to drive YAP activation in skin homeostasis and repair. Nature Cell Biology, 27, 2032-2032. External link
Shalev Ezra, Y., Saguy, A., Levin, G., Weiss, L., Alalouf, O., & Shechtman, Y. (2025). High-throughput DNA repair monitoring in Saccharomyces cerevisiae suggests SSB- and DSB-induced chromatin reconfiguration. Scientific Reports, 15(1), 32302 (14 pages). External link
Simon, F., Weiss, L., & van Teeffelen, S. (2024). A guide to single-particle tracking. Nature Reviews Methods Primers, 4, 67. External link
Sedov, E., Koren, E., Chopra, S., Ankawa, R., Yosefzon, Y., Yusupova, M., Weiss, L., Mahly, A., Soffer, A., Feldman, A., Luxenburg, C., Shechtman, Y., & Fuchs, Y. (2022). THY1-mediated mechanisms converge to drive YAP activation in skin homeostasis and repair. Nature Cell Biology, 24(7), 1049-1063. External link
Saguy, A., Baldering, T. N., Weiss, L., Nehme, E., Karathanasis, C., Dietz, M. S., Heilemann, M., & Shechtman, Y. (2021). Automated Analysis of Fluorescence Kinetics in Single-Molecule Localization Microscopy Data Reveals Protein Stoichiometry. The Journal of Physical Chemistry B, 125(22), 5716-5721. External link
Shechtman, Y., Moerner, W. E., Weiss, L., & Sahl, S. J. (2019). Apparatuses and methods for three-dimensional imaging of an object. (Patent Application no. US20160301915). External link
Shechtman, Y., Moerner, W. E., & Weiss, L. (2019). Multi-wavelength phase mask. (Patent Application no. US20160301914). External link
Sahl, S. J., Lau, L., Vonk, W. I. M., Weiss, L., Frydman, J., & Moerner, W. E. (2016). Delayed emergence of subdiffraction-sized mutant huntingtin fibrils following inclusion body formation. Quarterly Reviews of Biophysics, 49, e2-e2. External link
Shechtman, Y., Weiss, L., Backer, A. S., Lee, M. Y., & Moerner, W. E. (2016). Multicolour localization microscopy by point-spread-function engineering. Nature Photonics, 10(9), 590-594. External link
Shechtman, Y., Sahl, S. J., Weiss, L., Backer, A. S., & Moerner, W. E. (2015, April). Optimal point spread function for 3D high-precision imaging [Paper]. Novel Techniques in Microscopy (NTM 2015). Unavailable
Shechtman, Y., Weiss, L., Backer, A. S., Sahl, S. J., & Moerner, W. E. (2015). Precise Three-Dimensional Scan-Free Multiple-Particle Tracking over Large Axial Ranges with Tetrapod Point Spread Functions. Nano Letters, 15(6), 4194-4199. External link
Sahl, S. J., Weiss, L., Duim, W. C., Frydman, J., & Moerner, W. E. (2012). Cellular Inclusion Bodies of Mutant Huntingtin Exon 1 Obscure Small Fibrillar Aggregate Species. Scientific Reports, 2(1), 895-895. External link
Weiss, L., Love, J. F., Yoon, J., Comerci, C. J., Milenković, L., Kanie, T., Jackson, P. K., Stearns, T., & Gustavsson, A.-K. (2023). Single-molecule imaging in the primary cilium. In Bravo-San Pedro, J. M., & Galluzzi, L. (eds.), Cilia: From Mechanisms to Disease - Part B (Vol. 176, pp. 59-83). External link
Weiss, L., Shalev Ezra, Y., Goldberg, S., Ferdman, B., Adir, O., Schroeder, A., Alalouf, O., & Shechtman, Y. (2020). Three-dimensional localization microscopy in live flowing cells. Nature Nanotechnology, 15(6), 500-506. External link
Weiss, L., & Shechtman, Y. (2019). High throughput three-dimensional multicolor localization by point-spread-function engineering in imaging flow cytometry. (Patent Application no. WO2019180705). External link
Weiss, L., Milenkovic, L., Yoon, J., Stearns, T., & Moerner, W. E. (2019). Motional dynamics of single Patched1 molecules in cilia are controlled by Hedgehog and cholesterol. Proc Natl Acad Sci U.S.A., 116(12), 5550-5557. External link
Weiss, L., Naor, T., & Shechtman, Y. (2018). Observing DNA in live cells. Biochemical Society Transactions, 46(3), 729-740. External link
Weiss, L., Badalamenti, J. P., Weaver, L. J., Tascone, A. R., Weiss, P. S., Richard, T. L., & Cirino, P. C. (2008). Engineering motility as a phenotypic response to LuxI/R-dependent quorum sensing in Escherichia coli. Biotechnology and Bioengineering, 100(6), 1251-5. External link
Yoon, J., Comerci, C. J., Weiss, L., Milenkovic, L., Stearns, T., & Moerner, W. E. (2019). Revealing nanoscale morphology of the primary cilium using super-resolution fluorescence microscopy. Biophys Journal, 116(2), 319-329. Available
Yoon, J., Weiss, L., Milenković, L., Stearns, T., & Moerner, W. E. (2018). Quantifying Nanoscale Morphological Features of the Primary Cilium Membrane using Super-Resolution Fluorescence Microscopy. Biophysical Journal, 114(3), 268a-268a. External link
Zhang, B., Daly, S., Zhu, C., Lenz, M. O., Weiss, L., Needham, L.-M., Peters, R., Lee, S. F., & O’Holleran, K. (2024). Vortex light field microscopy : 3D spectral single-molecule imaging with a twist. Optica, 11(11), 1519-1525. Available
Zsok, J., Simon, F., Bayrak, G., Isaki, L., Kerff, N., Kicheva, Y., Wolstenholme, A., Weiss, L., & Dultz, E. (2024). Nuclear basket proteins regulate the distribution and mobility of nuclear pore complexes in budding yeast. Molecular Biology of the Cell, E24-08-037 (27 pages). External link
