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Antimicrobial properties of the Ag, Cu Nanoparticle System

Xinzhen Fan, L'Hocine Yahia and Edward Sacher

Article (2021)

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Microbes, including bacteria and fungi, easily form stable biofilms on many surfaces. Such biofilms have high resistance to antibiotics, and cause nosocomial and postoperative infections. The antimicrobial and antiviral behaviors of Ag and Cu nanoparticles (NPs) are well known, and possible mechanisms for their actions, such as released ions, reactive oxygen species (ROS), contact killing, the immunostimulatory effect, and others have been proposed. Ag and Cu NPs, and their derivative NPs, have different antimicrobial capacities and cytotoxicities. Factors, such as size, shape and surface treatment, influence their antimicrobial activities. The biomedical application of antimicrobial Ag and Cu NPs involves coating onto substrates, including textiles, polymers, ceramics, and metals. Because Ag and Cu are immiscible, synthetic AgCu nanoalloys have different microstructures, which impact tHeir antimicrobial effects. When mixed, the Combination of Ag and Cu NPs act synergistically, offering substantially enhanced antimicrobial behavior. However, when alloyed in Ag–Cu NPs, the antimicrobial behavior is even more enhanced. The reason for this enhancement is unclear. Here, we discuss these results and the possible behavior mechanisms that underlie them.

Uncontrolled Keywords

antibacterial; biofilm; metal nanoparticles

Subjects: 1900 Biomedical engineering > 1900 Biomedical engineering
1900 Biomedical engineering > 1901 Biomedical technology
1900 Biomedical engineering > 1902 Biomedical materials
1900 Biomedical engineering > 1903 Biomechanics
2100 Mechanical engineering > 2100 Mechanical engineering
3100 Physics > 3100 Physics
Department: Department of Mechanical Engineering
Department of Engineering Physics
Research Center: LIAB - Bioperformance Analysis and Innovation Laboratory
Funders: CRSNG / NSERC
PolyPublie URL: https://publications.polymtl.ca/9366/
Journal Title: Biology (vol. 10, no. 2)
Publisher: MDPI
DOI: 10.3390/biology10020137
Official URL: https://doi.org/10.3390/biology10020137
Date Deposited: 16 Aug 2023 11:50
Last Modified: 09 Apr 2024 06:47
Cite in APA 7: Fan, X., Yahia, L., & Sacher, E. (2021). Antimicrobial properties of the Ag, Cu Nanoparticle System. Biology, 10(2), 37 pages. https://doi.org/10.3390/biology10020137


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