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Atlas-based quantification of DTI measures in a typically developing pediatric spinal cord

S. Shahrampour, Benjamin De Leener, M. Alizadeh, D. Middleton, L. Krisa, A.E. Flanders, S.H. Faro, Julien Cohen-Adad et F.B. Mohamed

Article de revue (2021)

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Abstract

BACKGROUND AND PURPOSE: Multi-parametric MRI, provides a variety of biomarkers sensitive to white matter integrity, However, spinal cord MRI data in pediatrics is rare compared to adults. The purpose of this work was 3-fold: 1) to develop a processing pipeline for atlasbased generation of the typically developing pediatric spinal cord WM tracts, 2) to derive atlas-based normative values of the DTI indices for various WM pathways, and 3) to investigate age-related changes in the obtained normative DTI indices along the extracted tracts. MATERIALS AND METHODS: DTI scans of 30 typically developing subjects (age range, 6–16 years) were acquired on a 3T MR imaging scanner. The data were registered to the PAM50 template in the Spinal Cord Toolbox. Next, the DTI indices for various WM regions were extracted at a single section centered at the C3 vertebral body in all the 30 subjects. Finally, an ANOVA test was performed to examine the effects of the following: 1) laterality, 2) functionality, and 3) age, with DTI-derived indices in 34 extracted WM regions. RESULTS: A postprocessing pipeline was developed and validated to delineate pediatric spinal cord WM tracts. The results of ANOVA on fractional anisotropy values showed no effect for laterality (P ¼ .72) but an effect for functionality (P , .001) when comparing the 30 primary WM labels. There was a significant (P , .05) effect of age and maturity of the left spinothalamic tract on mean diffusivity, radial diffusivity, and axial diffusivity values. CONCLUSIONS: The proposed automated pipeline in this study incorporates unique postprocessing steps followed by template registration and quantification of DTI metrics using atlas-based regions. This method eliminates the need for manual ROI analysis of WM tracts and, therefore, increases the accuracy and speed of the measurements.

Sujet(s): 1900 Génie biomédical > 1900 Génie biomédical
1900 Génie biomédical > 1901 Technologie biomédicale
Département: Département de génie informatique et génie logiciel
Institut de génie biomédical
Centre de recherche: NeuroPoly - Laboratoire de Recherche en Neuroimagerie
Organismes subventionnaires: National Institutes of Health - National Institute of Neurological Disorders
Numéro de subvention: R01NS079635, R01NS111113
URL de PolyPublie: https://publications.polymtl.ca/9363/
Titre de la revue: American Journal of Neuroradiology (vol. 42, no 9)
Maison d'édition: American Society of Neuroradiology
DOI: 10.3174/ajnr.a7221
URL officielle: https://doi.org/10.3174/ajnr.a7221
Date du dépôt: 11 août 2022 13:40
Dernière modification: 28 mars 2024 12:21
Citer en APA 7: Shahrampour, S., De Leener, B., Alizadeh, M., Middleton, D., Krisa, L., Flanders, A.E., Faro, S.H., Cohen-Adad, J., & Mohamed, F.B. (2021). Atlas-based quantification of DTI measures in a typically developing pediatric spinal cord. American Journal of Neuroradiology, 42(9), 1727-1734. https://doi.org/10.3174/ajnr.a7221

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