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Cerebral tissue pO2 response to treadmill exercise in awake mice

Mohammad Moeini, Christophe Cloutier-Tremblay, Xuecong Lu, Ashok Kakkar and Frédéric Lesage

Article (2020)

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Abstract

We exploited two-photon microscopy and Doppler optical coherence tomography to examine the cerebral blood flow and tissue pO2 response to forced treadmill exercise in awake mice. To our knowledge, this is the first study performing both direct measure of brain tissue pO2 during acute forced exercise and underlying microvascular response at capillary and non-capillary levels. We observed that cerebral perfusion and oxygenation are enhanced during running at 5 m/min compared to rest. At faster running speeds (10 and 15 m/min), decreasing trends in arteriolar and capillary flow speed were observed, which could be due to cerebral autoregulation and constriction of arterioles in response to blood pressure increase. However, tissue pO2 was maintained, likely due to an increase in RBC linear density. Higher cerebral oxygenation at exercise levels 5–15 m/min suggests beneficial effects of exercise in situations where oxygen delivery to the brain is compromised, such as in aging, atherosclerosis and Alzheimer Disease.

Uncontrolled Keywords

Circulation, Fluorescence imaging, Molecular imaging, Neuroscience, Optical imaging

Additional Information: Supplementary information is available for this paper at https://doi.org/10.1038/s41598-020-70413-3.
Subjects: 1900 Biomedical engineering > 1900 Biomedical engineering
1900 Biomedical engineering > 1901 Biomedical technology
1900 Biomedical engineering > 1903 Biomechanics
Department: Institut de génie biomédical
Funders: CRSNG/NSERC, Canadian Institutes of Health Research
Grant number: 239876-2011, 299166
PolyPublie URL: https://publications.polymtl.ca/9290/
Journal Title: Scientific Reports (vol. 10, no. 1)
Publisher: Springer Nature
DOI: 10.1038/s41598-020-70413-3
Official URL: https://doi.org/10.1038/s41598-020-70413-3
Date Deposited: 01 Mar 2023 14:04
Last Modified: 17 Feb 2025 22:44
Cite in APA 7: Moeini, M., Cloutier-Tremblay, C., Lu, X., Kakkar, A., & Lesage, F. (2020). Cerebral tissue pO2 response to treadmill exercise in awake mice. Scientific Reports, 10(1), 13358 (11 pages). https://doi.org/10.1038/s41598-020-70413-3

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