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Transdermal delivery of cannabidiol for the management of acute inflammatory pain : a comprehensive review of the literature

Ève Lefebvre, Nancy Tawil and L'Hocine Yahia

Article (2024)

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Abstract

The emerging field of nanotechnology has paved the way for revolutionary advancements in drug delivery systems, with nanosystems emerging as a promising avenue for enhancing the therapeutic potential and the stability of various bioactive compounds. Among these, cannabidiol (CBD), the non-psychotropic compound of the Cannabis sativa plant, has gained attention for its therapeutic properties. Consequently, researchers have devoted significant efforts to unlock the full potential of CBD’s clinical benefits, where various nanosystems and excipients have emerged to overcome challenges associated with its bioavailability, stability, and controlled release for its transdermal application. Therefore, this comprehensive review aims to explain CBD’s role in managing acute inflammatory pain and offers an overview of the state of the art of existing delivery systems and excipients for CBD. To summarize this review, a summary of the cannabinoids and therapeutical targets of CBD will be discussed, followed by its conventional modes of administration. The transdermal route of administration and the current topical and transdermal delivery systems will also be reviewed. This review will conclude with an overview of in vivo techniques that allow the evaluation of the anti-inflammatory and analgesic potentials of these systems.

Uncontrolled Keywords

cannabidiol; transdermal; delivery; polymeric; inflammation; arthritis; cannabis

Subjects: 1900 Biomedical engineering > 1900 Biomedical engineering
1900 Biomedical engineering > 1901 Biomedical technology
1900 Biomedical engineering > 1902 Biomedical materials
1900 Biomedical engineering > 1903 Biomechanics
Department: Department of Mechanical Engineering
Funders: Mitacs
Grant number: IT29500
PolyPublie URL: https://publications.polymtl.ca/58575/
Journal Title: International Journal of Molecular Sciences (vol. 25, no. 11)
Publisher: MDPI
DOI: 10.3390/ijms25115858
Official URL: https://doi.org/10.3390/ijms25115858
Date Deposited: 17 Jun 2024 16:50
Last Modified: 28 Sep 2024 23:34
Cite in APA 7: Lefebvre, È., Tawil, N., & Yahia, L. (2024). Transdermal delivery of cannabidiol for the management of acute inflammatory pain : a comprehensive review of the literature. International Journal of Molecular Sciences, 25(11), 5858 (20 pages). https://doi.org/10.3390/ijms25115858

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