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Evidence-based commentary on the diagnosis, management, and further research of degenerative cervical spinal cord compression in the absence of clinical symptoms of myelopathy

Tomáš Horák, Magda Horáková, Miloš Keřkovský, Marek Dostál, Petr Hluštı́k, Jan Valošek, Alena Svátková, Petr Bednařík, Eva Vlčková and Josef Bednařík

Article (2024)

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Abstract

Degenerative cervical myelopathy (DCM) represents the final consequence of a series of degenerative changes in the cervical spine, resulting in cervical spinal canal stenosis and mechanical stress on the cervical spinal cord. This process leads to subsequent pathophysiological processes in the spinal cord tissues. The primary mechanism of injury is degenerative compression of the cervical spinal cord, detectable by magnetic resonance imaging (MRI), serving as a hallmark for diagnosing DCM. However, the relative resilience of the cervical spinal cord to mechanical compression leads to clinical-radiological discordance, i.e., some individuals may exhibit MRI findings of DCC without the clinical signs and symptoms of myelopathy. This degenerative compression of the cervical spinal cord without clinical signs of myelopathy, potentially serving as a precursor to the development of DCM, remains a somewhat controversial topic. In this review article, we elaborate on and provide commentary on the terminology, epidemiology, natural course, diagnosis, predictive value, risks, and practical management of this condition—all of which are subjects of ongoing debate.

Uncontrolled Keywords

degenerative cervical cord compression; degenerative cervical myelopathy; cervical spinal canal stenosis; magnetic resonance imaging; subclinical myelopathy

Subjects: 1900 Biomedical engineering > 1900 Biomedical engineering
1900 Biomedical engineering > 1901 Biomedical technology
Department: Institut de génie biomédical
Research Center: NeuroPoly - Laboratoire de Recherche en Neuroimagerie
Funders: Czech Health Research Council, Czech Republic - Ministry of Health, European Union’s Horizon Europe Research and Innovation - Marie Sklodowska-Curie
Grant number: NU22-04-00024, FNBr, 65269705, FNOl, 00098892, 101107932
PolyPublie URL: https://publications.polymtl.ca/58561/
Journal Title: Frontiers in Neurology (vol. 15)
Publisher: Frontiers
DOI: 10.3389/fneur.2024.1341371
Official URL: https://doi.org/10.3389/fneur.2024.1341371
Date Deposited: 26 Jun 2024 12:58
Last Modified: 01 Oct 2024 13:33
Cite in APA 7: Horák, T., Horáková, M., Keřkovský, M., Dostál, M., Hluštı́k, P., Valošek, J., Svátková, A., Bednařík, P., Vlčková, E., & Bednařík, J. (2024). Evidence-based commentary on the diagnosis, management, and further research of degenerative cervical spinal cord compression in the absence of clinical symptoms of myelopathy. Frontiers in Neurology, 15, 9 pages. https://doi.org/10.3389/fneur.2024.1341371

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