Tomáš Horák, Magda Horáková, Miloš Keřkovský, Marek Dostál, Petr Hluštı́k, Jan Valošek, Alena Svátková, Petr Bednařík, Eva Vlčková and Josef Bednařík
Article (2024)
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Open Access to the full text of this document Published Version Terms of Use: Creative Commons Attribution Download (1MB) |
Abstract
Degenerative cervical myelopathy (DCM) represents the final consequence of a series of degenerative changes in the cervical spine, resulting in cervical spinal canal stenosis and mechanical stress on the cervical spinal cord. This process leads to subsequent pathophysiological processes in the spinal cord tissues. The primary mechanism of injury is degenerative compression of the cervical spinal cord, detectable by magnetic resonance imaging (MRI), serving as a hallmark for diagnosing DCM. However, the relative resilience of the cervical spinal cord to mechanical compression leads to clinical-radiological discordance, i.e., some individuals may exhibit MRI findings of DCC without the clinical signs and symptoms of myelopathy. This degenerative compression of the cervical spinal cord without clinical signs of myelopathy, potentially serving as a precursor to the development of DCM, remains a somewhat controversial topic. In this review article, we elaborate on and provide commentary on the terminology, epidemiology, natural course, diagnosis, predictive value, risks, and practical management of this condition—all of which are subjects of ongoing debate.
Uncontrolled Keywords
degenerative cervical cord compression; degenerative cervical myelopathy; cervical spinal canal stenosis; magnetic resonance imaging; subclinical myelopathy
Subjects: |
1900 Biomedical engineering > 1900 Biomedical engineering 1900 Biomedical engineering > 1901 Biomedical technology |
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Department: | Institut de génie biomédical |
Research Center: | NeuroPoly - Laboratoire de Recherche en Neuroimagerie |
Funders: | Czech Health Research Council, Czech Republic - Ministry of Health, European Union’s Horizon Europe Research and Innovation - Marie Sklodowska-Curie |
Grant number: | NU22-04-00024, FNBr, 65269705, FNOl, 00098892, 101107932 |
PolyPublie URL: | https://publications.polymtl.ca/58561/ |
Journal Title: | Frontiers in Neurology (vol. 15) |
Publisher: | Frontiers |
DOI: | 10.3389/fneur.2024.1341371 |
Official URL: | https://doi.org/10.3389/fneur.2024.1341371 |
Date Deposited: | 26 Jun 2024 12:58 |
Last Modified: | 01 Oct 2024 13:33 |
Cite in APA 7: | Horák, T., Horáková, M., Keřkovský, M., Dostál, M., Hluštı́k, P., Valošek, J., Svátková, A., Bednařík, P., Vlčková, E., & Bednařík, J. (2024). Evidence-based commentary on the diagnosis, management, and further research of degenerative cervical spinal cord compression in the absence of clinical symptoms of myelopathy. Frontiers in Neurology, 15, 9 pages. https://doi.org/10.3389/fneur.2024.1341371 |
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