Continuous penicillin V production by immobilized penicillium chrysogenum in an inverse fluidized bed reactor

General background and theoretical principles -- Penicillin fermentation -- Inverse fluidized bed bioreactor -- Sterilization -- Experimental -- Sterilization of polystyrene beads -- Design of IFBBR used for pure culture fermentation -- Composition of medium -- Spore production -- Immobilization on polystyrene beads -- Determination of limiting phosphate concentration -- Evaluation of IFBBR -- Analytical procedures -- Results -- Sterilization -- Eroder -- Immobilization -- Biomass analysis -- Determination of limiting phosphate concentration -- Evaluation of IFBBR.