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An electrochemical study on the effect of metal chelation and reactive oxygen species on a synthetic neuromelanin model

Ri Xu, Francesca Soavi and Clara Santato

Article (2019)

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Abstract

Neuromelanin is present in the cathecolaminergic neuron cells of the substantia nigra and locus coeruleus of the midbrain of primates. Neuromelanin plays a role in Parkinson's disease (PD). Literature reports that neuromelanin features, among others, antioxidant properties by metal ion chelation and free radical scavenging. The pigment has been reported to have prooxidant properties too, in certain experimental conditions. We propose an explorative electrochemical study of the effect of the presence of metal ions and reactive oxygen species (ROS) on the cyclic voltammograms of a synthetic model of neuromelanin. Our work improves the current understanding on experimental conditions where neuromelanin plays an antioxidant or prooxidant behavior, thus possibly contributing to shed light on factors promoting the appearance of PD.

Uncontrolled Keywords

antioxidant behavior; cyclic voltammetry; hydrogen peroxide; metal chelation; neuromelanin (NM); radical scavenging; reactive oxygen species; redox properties

Subjects: 1800 Chemical engineering > 1800 Chemical engineering
6400 Life sciences research related to human health and disease > 6400 Life sciences research related to human health and disease
Department: Department of Engineering Physics
Funders: Italy-Quebec Mobility program (MRIF and Italian Minister of Foreign Affairs), NSERC (Discovery)
PolyPublie URL: https://publications.polymtl.ca/5178/
Journal Title: Frontiers in Bioengineering and Biotechnology (vol. 7)
Publisher: Frontiers
DOI: 10.3389/fbioe.2019.00227
Official URL: https://doi.org/10.3389/fbioe.2019.00227
Date Deposited: 13 Jul 2022 11:49
Last Modified: 08 Apr 2024 14:33
Cite in APA 7: Xu, R., Soavi, F., & Santato, C. (2019). An electrochemical study on the effect of metal chelation and reactive oxygen species on a synthetic neuromelanin model. Frontiers in Bioengineering and Biotechnology, 7, 227 (11 pages). https://doi.org/10.3389/fbioe.2019.00227

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