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Imaging the dynamics of cardiac fiber orientation in vivo using 3D Ultrasound Backscatter Tensor Imaging

Clement Papadacci, Victor Finel, Jean Provost, Olivier Villemain, Patrick Bruneval, Jean-Luc Gennisson, Mickael Tanter, Mathias Fink and Mathieu Pernot

Article (2017)

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Abstract

The assessment of myocardial fiber disarray is of major interest for the study of the progression of myocardial disease. However, time-resolved imaging of the myocardial structure remains unavailable in clinical practice. In this study, we introduce 3D Backscatter Tensor Imaging (3D-BTI), an entirely novel ultrasound-based imaging technique that can map the myocardial fibers orientation and its dynamics with a temporal resolution of 10 ms during a single cardiac cycle, non-invasively and in vivo in entire volumes. 3D-BTI is based on ultrafast volumetric ultrasound acquisitions, which are used to quantify the spatial coherence of backscattered echoes at each point of the volume. The capability of 3D-BTI to map the fibers orientation was evaluated in vitro in 5 myocardial samples. The helicoidal transmural variation of fiber angles was in good agreement with the one obtained by histological analysis. 3D-BTI was then performed to map the fiber orientation dynamics in vivo in the beating heart of an open-chest sheep at a volume rate of 90 volumes/s. Finally, the clinical feasibility of 3D-BTI was shown on a healthy volunteer. These initial results indicate that 3D-BTI could become a fully non-invasive technique to assess myocardial disarray at the bedside of patients.

Uncontrolled Keywords

Animals; Diffusion Tensor Imaging/*methods; Echocardiography, Three-Dimensional/*methods; Heart Ventricles/*diagnostic imaging; Humans; Sheep; Swine

Subjects: 1900 Biomedical engineering > 1900 Biomedical engineering
Department: Department of Engineering Physics
Funders: European Research Council under the European Union’s Seventh Framework Program, ERC Grant Agreement, LABEX WIFI, Marie Curie International Incoming Fellowship under the Seventh Framework Program for research (FP7) of the European Union
Grant number: FP/2007–2013, 11025, ANR-10-LABX-2, ANR-10- IDEX-0001-02 PSL
PolyPublie URL: https://publications.polymtl.ca/5072/
Journal Title: Scientific Reports (vol. 7, no. 1)
Publisher: Nature
DOI: 10.1038/s41598-017-00946-7
Official URL: https://doi.org/10.1038/s41598-017-00946-7
Date Deposited: 23 Feb 2023 14:49
Last Modified: 08 Apr 2024 03:41
Cite in APA 7: Papadacci, C., Finel, V., Provost, J., Villemain, O., Bruneval, P., Gennisson, J.-L., Tanter, M., Fink, M., & Pernot, M. (2017). Imaging the dynamics of cardiac fiber orientation in vivo using 3D Ultrasound Backscatter Tensor Imaging. Scientific Reports, 7(1), 830 (9 pages). https://doi.org/10.1038/s41598-017-00946-7

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