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Targeting active cancer cells with smart bullets

Sylvain Martel

Article (2017)

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Cite this document: Martel, S. (2017). Targeting active cancer cells with smart bullets. Therapeutic Delivery, 8(5), p. 301-312. doi:10.4155/tde-2016-0088
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Abstract

Paul Ehrlich's 'magic bullet' concept has stimulated research for therapeutic agents with the capability to go straight to their intended targets. The 'magic bullet' concept is still considered the ultimate approach to maximize the therapeutic effects of a given therapeutic agent without affecting nontargeted tissues. But so far, there has never been a therapeutic agent or a delivery system that goes straight to the target in the body, and no approach has provided anything better than just a few percents of the total administered dose reaching the intended target sites. But engineering principles can transform systematically circulating vectors that so far were based primarily on physical characteristics and biochemical principles alone, as smart therapeutic agents with the required propulsion-navigation-homing capabilities to enable them to go straight to their intended targets.

Uncontrolled Keywords

*Drug Delivery Systems; Humans; Neoplasms/*drug therapy; *cancer translational research; *clinical MRI scanner; *high therapeutic index; *magnetic fields; *magnetotactic bacteria; *nonsystemic therapeutic delivery; *robotic functionalities; *smart delivery agents; *targeting active cancer cells; *tumor hypoxic zones; *vascular navigation

Open Access document in PolyPublie
Subjects: 1900 Génie biomédical > 1900 Génie biomédical
Department: Département de génie informatique et génie logiciel
Institut de génie biomédical
Research Center: Laboratoire de NanoRobotique
Funders: Polytechnique Montréal, Univalor, Consortium Québécois sur la Découverte du Médicament, Canada Research Chairs / Chaires de recherche du Canada, CRSNG/NSERC, Gouvernement du Québec, Mitacs, Canadian Foundation for Innovation / Fondation canadienne pour l'innovation (CFI), National Institutes of Health (NIH)
Date Deposited: 17 Dec 2021 11:12
Last Modified: 22 Mar 2022 11:17
PolyPublie URL: https://publications.polymtl.ca/5019/
Document issued by the official publisher
Journal Title: Therapeutic Delivery (vol. 8, no. 5)
Publisher: Future Science
Official URL: https://doi.org/10.4155/tde-2016-0088

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