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Atherosclerosis is associated with a decrease in cerebral microvascular blood flow and tissue oxygenation

Baoqiang Li, Xuecong Lu, Mohammad Moeini, Sava Sakadzic, Eric Thorin et Frédéric Lesage

Article de revue (2019)

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Abstract

Chronic atherosclerosis may cause cerebral hypoperfusion and inadequate brain oxygenation, contributing to the progression of cognitive decline. In this study, we exploited two-photon phosphorescence lifetime microscopy to measure the absolute partial pressure of oxygen (PO2) in cortical tissue in both young and old LDLR-/-, hApoB100+/+ mice, spontaneously developing atherosclerosis with age. Capillary red-blood-cell (RBC) speed, flux, hematocrit and capillary diameter were also measured by two-photon imaging of FITC-labelled blood plasma. Our results show positive correlations between RBC speed, flux, diameter and capillary-adjacent tissue PO2. When compared to the young mice, we observed lower tissue PO2, lower RBC speed and flux, and smaller capillary diameter in the old atherosclerotic mice. The old mice also exhibited a higher spatial heterogeneity of tissue PO2, and RBC speed and flux, suggesting a less efficient oxygen extraction.

Sujet(s): 1900 Génie biomédical > 1900 Génie biomédical
Département: Institut de génie biomédical
Organismes subventionnaires: CRSNG/NSERC
URL de PolyPublie: https://publications.polymtl.ca/5002/
Titre de la revue: PLOS One (vol. 14, no 8)
Maison d'édition: PLOS
DOI: 10.1371/journal.pone.0221547
URL officielle: https://doi.org/10.1371/journal.pone.0221547
Date du dépôt: 05 avr. 2022 14:36
Dernière modification: 12 mai 2023 17:43
Citer en APA 7: Li, B., Lu, X., Moeini, M., Sakadzic, S., Thorin, E., & Lesage, F. (2019). Atherosclerosis is associated with a decrease in cerebral microvascular blood flow and tissue oxygenation. PLOS One, 14(8), e0221547 (13 pages). https://doi.org/10.1371/journal.pone.0221547

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