<  Back to the Polytechnique Montréal portal

Atherosclerosis is associated with a decrease in cerebral microvascular blood flow and tissue oxygenation

Baoqiang Li, Xuecong Lu, Mohammad Moeini, Sava Sakadzic, Eric Thorin and Frédéric Lesage

Article (2019)

Open Acess document in PolyPublie and at official publisher
Open Access to the full text of this document
Published Version
Terms of Use: Creative Commons Attribution
Download (784kB)
Show abstract
Hide abstract


Chronic atherosclerosis may cause cerebral hypoperfusion and inadequate brain oxygenation, contributing to the progression of cognitive decline. In this study, we exploited two-photon phosphorescence lifetime microscopy to measure the absolute partial pressure of oxygen (PO2) in cortical tissue in both young and old LDLR-/-, hApoB100+/+ mice, spontaneously developing atherosclerosis with age. Capillary red-blood-cell (RBC) speed, flux, hematocrit and capillary diameter were also measured by two-photon imaging of FITC-labelled blood plasma. Our results show positive correlations between RBC speed, flux, diameter and capillary-adjacent tissue PO2. When compared to the young mice, we observed lower tissue PO2, lower RBC speed and flux, and smaller capillary diameter in the old atherosclerotic mice. The old mice also exhibited a higher spatial heterogeneity of tissue PO2, and RBC speed and flux, suggesting a less efficient oxygen extraction.

Subjects: 1900 Biomedical engineering > 1900 Biomedical engineering
Department: Institut de génie biomédical
PolyPublie URL: https://publications.polymtl.ca/5002/
Journal Title: PLOS One (vol. 14, no. 8)
Publisher: PLOS
DOI: 10.1371/journal.pone.0221547
Official URL: https://doi.org/10.1371/journal.pone.0221547
Date Deposited: 05 Apr 2022 14:36
Last Modified: 09 Apr 2024 11:08
Cite in APA 7: Li, B., Lu, X., Moeini, M., Sakadzic, S., Thorin, E., & Lesage, F. (2019). Atherosclerosis is associated with a decrease in cerebral microvascular blood flow and tissue oxygenation. PLOS One, 14(8), e0221547 (13 pages). https://doi.org/10.1371/journal.pone.0221547


Total downloads

Downloads per month in the last year

Origin of downloads


Repository Staff Only

View Item View Item