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Biomechanical simulations of the scoliotic deformation process in the pinealectomized chicken: a preliminary study

Pierre Lafortune, Carl-Éric Aubin, Hugo Boulanger, Isabelle Villemure, Keith M. Bagnall and Alain Moreau

Article (2007)

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BACKGROUND: The basic mechanisms whereby mechanical factors modulate the metabolism of the growing spine remain poorly understood, especially the role of growth adaptation in spinal disorders like in adolescent idiopathic scoliosis (AIS). This paper presents a finite element model (FEM) that was developed to simulate early stages of scoliotic deformities progression using a pinealectomized chicken as animal model.

METHODS: The FEM includes basic growth and growth modulation created by the muscle force imbalance. The experimental data were used to adapt a FEM previously developed to simulate the scoliosis deformation process in human. The simulations of the spine deformation process are compared with the results of an experimental study including a group of pinealectomized chickens. RESULTS: The comparison of the simulation results of the spine deformation process (Cobb angle of 37 degrees ) is in agreement with experimental scoliotic deformities of two representative cases (Cobb angle of 41 degrees and 30 degrees ). For the vertebral wedging, a good agreement is also observed between the calculated (28 degrees ) and the observed (25 degrees - 30 degrees ) values.

CONCLUSION: The proposed biomechanical model presents a novel approach to realistically simulate the scoliotic deformation process in pinealectomized chickens and investigate different parameters influencing the progression of scoliosis.

Subjects: 1900 Biomedical engineering > 1900 Biomedical engineering
9000 Health sciences > 9000 Health sciences
Department: Department of Mechanical Engineering
Research Center: Other
Grant number: CRSNG/NSERC, Chaires de recherche du Canada/Canada Research Chair, Fondation canadienne d'orthopédie/Canadian Orthopaedic Foundation
PolyPublie URL: https://publications.polymtl.ca/4982/
Journal Title: Scoliosis and Spinal Disorders (vol. 2, no. 1)
Publisher: BioMed Central
DOI: 10.1186/1748-7161-2-16
Official URL: https://doi.org/10.1186/1748-7161-2-16
Date Deposited: 06 Nov 2020 11:41
Last Modified: 29 Sep 2023 14:39
Cite in APA 7: Lafortune, P., Aubin, C.-É., Boulanger, H., Villemure, I., Bagnall, K. M., & Moreau, A. (2007). Biomechanical simulations of the scoliotic deformation process in the pinealectomized chicken: a preliminary study. Scoliosis and Spinal Disorders, 2(1), 16. https://doi.org/10.1186/1748-7161-2-16


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