Haleh Karbasforoushan, Julien Cohen-Adad et Julius P. A. Dewald
Article de revue (2019)
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Abstract
Damage to the corticospinal tract is widely studied following unilateral subcortical stroke, whereas less is known about changes to other sensorimotor pathways. This may be due to the fact that many studies investigated morphological changes in the brain, where the majority of descending and ascending brain pathways are overlapping, and did not investigate the brainstem where they separate. Moreover, these pathways continue passing through separate regions in the spinal cord. Here, using a high-resolution structural MRI of both the brainstem and the cervical spinal cord, we were able to identify a number of microstructurally altered pathways, in addition to the corticospinal tract, post stroke. Moreover, decreases in ipsi-lesional corticospinal tract integrity and increases in contra-lesional medial reticulospinal tract integrity were correlated with motor impairment severity in individuals with stroke.
Mots clés
Aged; Brain Stem/diagnostic imaging/*pathology; Case-Control Studies; Cervical Vertebrae; Female; Healthy Volunteers; Humans; *Magnetic Resonance Imaging; Male; Middle Aged; Neural Pathways/diagnostic imaging/pathology; Paresis/*diagnostic imaging/etiology/pathology; Spinal Cord/diagnostic imaging/*pathology; Stroke/*complications/diagnostic imaging/pathology; Upper Extremity/innervation; White Matter/diagnostic imaging/pathology
Sujet(s): | 9000 Sciences de la santé > 9000 Sciences de la santé |
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Département: | Institut de génie biomédical |
Centre de recherche: | NeuroPoly - Laboratoire de Recherche en Neuroimagerie |
Organismes subventionnaires: | National Institutes of Health |
Numéro de subvention: | R01HD039343, R01NS105759, NIH NRSA F31NS105486 |
URL de PolyPublie: | https://publications.polymtl.ca/4962/ |
Titre de la revue: | Nature Communications (vol. 10, no 1) |
Maison d'édition: | Nature Research |
DOI: | 10.1038/s41467-019-11244-3 |
URL officielle: | https://doi.org/10.1038/s41467-019-11244-3 |
Date du dépôt: | 25 mars 2022 15:37 |
Dernière modification: | 25 avr. 2024 12:35 |
Citer en APA 7: | Karbasforoushan, H., Cohen-Adad, J., & Dewald, J. P. A. (2019). Brainstem and spinal cord MRI identifies altered sensorimotor pathways post-stroke. Nature Communications, 10(1), 3524 (7 pages). https://doi.org/10.1038/s41467-019-11244-3 |
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