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Brainstem and spinal cord MRI identifies altered sensorimotor pathways post-stroke

Haleh Karbasforoushan, Julien Cohen-Adad, Julius P. A. Dewald

Article (2019)

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Damage to the corticospinal tract is widely studied following unilateral subcortical stroke, whereas less is known about changes to other sensorimotor pathways. This may be due to the fact that many studies investigated morphological changes in the brain, where the majority of descending and ascending brain pathways are overlapping, and did not investigate the brainstem where they separate. Moreover, these pathways continue passing through separate regions in the spinal cord. Here, using a high-resolution structural MRI of both the brainstem and the cervical spinal cord, we were able to identify a number of microstructurally altered pathways, in addition to the corticospinal tract, post stroke. Moreover, decreases in ipsi-lesional corticospinal tract integrity and increases in contra-lesional medial reticulospinal tract integrity were correlated with motor impairment severity in individuals with stroke.

Uncontrolled Keywords

Aged; Brain Stem/diagnostic imaging/*pathology; Case-Control Studies; Cervical Vertebrae; Female; Healthy Volunteers; Humans; *Magnetic Resonance Imaging; Male; Middle Aged; Neural Pathways/diagnostic imaging/pathology; Paresis/*diagnostic imaging/etiology/pathology; Spinal Cord/diagnostic imaging/*pathology; Stroke/*complications/diagnostic imaging/pathology; Upper Extremity/innervation; White Matter/diagnostic imaging/pathology

Subjects: 9000 Health sciences > 9000 Health sciences
Department: Institut de génie biomédical
Research Center: NeuroPoly - Laboratoire de Recherche en Neuroimagerie
Funders: National Institutes of Health
Grant number: R01HD039343, R01NS105759, NIH NRSA F31NS105486
PolyPublie URL: https://publications.polymtl.ca/4962/
Journal Title: Nature Communications (vol. 10, no. 1)
Publisher: Nature Research
DOI: 10.1038/s41467-019-11244-3
Official URL: https://doi.org/10.1038/s41467-019-11244-3
Date Deposited: 25 Mar 2022 15:37
Last Modified: 07 Jun 2023 12:29
Cite in APA 7: Karbasforoushan, H., Cohen-Adad, J., & Dewald, J. P. A. (2019). Brainstem and spinal cord MRI identifies altered sensorimotor pathways post-stroke. Nature Communications, 10(1), 3524 (7 pages). https://doi.org/10.1038/s41467-019-11244-3


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