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Microfluidic multipoles theory and applications

Pierre-Alexandre Goyette, Étienne Boulais, Frédéric Normandeau, Gabriel Laberge, David Juncker and Thomas Gervais

Article (2019)

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Abstract

Microfluidic multipoles (MFMs) have been realized experimentally and hold promise for "open-space" biological and chemical surface processing. Whereas convective flow can readily be predicted using hydraulic-electrical analogies, the design of advanced microfluidic multipole is constrained by the lack of simple, accurate models to predict mass transport within them. In this work, we introduce the complete solutions to mass transport in multipolar microfluidics based on the iterative conformal mapping of 2D advection-diffusion around a simple edge into dipoles and multipolar geometries, revealing a rich landscape of transport modes. The models are validated experimentally with a library of 3D printed devices and found in excellent agreement. Following a theory-guided design approach, we further ideate and fabricate two classes of spatiotemporally reconfigurable multipolar devices that are used for processing surfaces with time-varying reagent streams, and to realize a multistep automated immunoassay. Overall, the results set the foundations for exploring, developing, and applying open-space microfluidic multipoles.

Subjects: 2200 Fluid mechanics > 2200 Fluid mechanics
Department: Department of Engineering Physics
Institut de génie biomédical
Funders: Fonds de Recherche du Québec-Nature et Technologies (FRQNT), Fonds de recherche du Québec, Établissement de nouveaux chercheurs, Fonds de recherche du Québec, Équipe, CRSNG/NSERC, Canada First Research Excellence Fund
Grant number: NSERC - RGPIN - 06409
PolyPublie URL: https://publications.polymtl.ca/4901/
Journal Title: Nature Communications (vol. 10, no. 1)
Publisher: Nature Research
DOI: 10.1038/s41467-019-09740-7
Official URL: https://doi.org/10.1038/s41467-019-09740-7
Date Deposited: 08 Apr 2022 11:10
Last Modified: 08 Apr 2024 15:48
Cite in APA 7: Goyette, P.-A., Boulais, É., Normandeau, F., Laberge, G., Juncker, D., & Gervais, T. (2019). Microfluidic multipoles theory and applications. Nature Communications, 10(1), 1781 (10 pages). https://doi.org/10.1038/s41467-019-09740-7

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