<  Back to the Polytechnique Montréal portal

Microfluidic multipoles theory and applications

Pierre-Alexandre Goyette, Étienne Boulais, Frédéric Normandeau, Gabriel Laberge, David Juncker and Thomas Gervais

Article (2019)

[img]
Preview
Published Version
Terms of Use: Creative Commons Attribution .
Download (1MB)
Cite this document: Goyette, P.-A., Boulais, É., Normandeau, F., Laberge, G., Juncker, D. & Gervais, T. (2019). Microfluidic multipoles theory and applications. Nature Communications, 10. doi:10.1038/s41467-019-09740-7
Show abstract Hide abstract

Abstract

Microfluidic multipoles (MFMs) have been realized experimentally and hold promise for "open-space" biological and chemical surface processing. Whereas convective flow can readily be predicted using hydraulic-electrical analogies, the design of advanced microfluidic multipole is constrained by the lack of simple, accurate models to predict mass transport within them. In this work, we introduce the complete solutions to mass transport in multipolar microfluidics based on the iterative conformal mapping of 2D advection-diffusion around a simple edge into dipoles and multipolar geometries, revealing a rich landscape of transport modes. The models are validated experimentally with a library of 3D printed devices and found in excellent agreement. Following a theory-guided design approach, we further ideate and fabricate two classes of spatiotemporally reconfigurable multipolar devices that are used for processing surfaces with time-varying reagent streams, and to realize a multistep automated immunoassay. Overall, the results set the foundations for exploring, developing, and applying open-space microfluidic multipoles.

Open Access document in PolyPublie
Subjects: 2200 Mécanique des fluides > 2200 Mécanique des fluides
Department: Département de génie physique
Institut de génie biomédical
Funders: Fonds de Recherche du Québec-Nature et Technologies (FRQNT), Fonds de recherche du Québec, Établissement de nouveaux chercheurs, Fonds de recherche du Québec, Équipe, CRSNG/NSERC, Canada First Research Excellence Fund
Grant number: NSERC - RGPIN - 06409
Date Deposited: 08 Apr 2022 11:10
Last Modified: 09 Apr 2022 01:20
PolyPublie URL: https://publications.polymtl.ca/4901/
Document issued by the official publisher
Journal Title: Nature Communications (vol. 10)
Publisher: Nature Research
Official URL: https://doi.org/10.1038/s41467-019-09740-7

Statistics

Total downloads

Downloads per month in the last year

Origin of downloads

Dimensions

Repository Staff Only