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Non-thermal plasma treatment induces MAPK signaling in human monocytes

Lena Bundscherer, Stefanie Nagel, Sybille Hasse, Helena Tresp, Kristian Wende, Reinhard Walther, Stephan Reuter, Klaus-Dieter Weltmann, Kai Masur and Ulrike Lindequist

Article (2015)

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The application of non-thermal atmospheric pressure plasma raises a hope for the new wound healing strategies. Next to its antibacterial effect it is known to stimulate skin cells. However, monocytes are also needed for the complex process of a wound healing. This study investigates the impact of plasma on the intracellular signaling events in the primary human monocytes. The proliferative MEK-ERK (MAPK/ERK kinase-extracellular signal-regulated kinase) pathway was activated by short plasma treatment times. In contrast, an induction of the apoptotic JNK (c-Jun N-terminal kinase) cascade as well as activation of caspase 3 were observed after long plasma exposure. These findings indicate that monocytes can be differentially stimulated by plasma treatment and may contribute to the proper wound recovery.

Uncontrolled Keywords

human monocytes, MAPK signaling, non-thermal plasma, plasma medicine, wound healing

Subjects: 3100 Physics > 3100 Physics
3100 Physics > 3101 Atomic and molecular studies
Department: Department of Engineering Physics
Funders: German Ministry of Education and Research
Grant number: BMBF grants 03Z2DN11, BMBF grants 03Z2DN12
PolyPublie URL: https://publications.polymtl.ca/4811/
Journal Title: Open Chemistry (vol. 13, no. 1)
Publisher: De Gruyter
DOI: 10.1515/chem-2015-0071
Official URL: https://doi.org/10.1515/chem-2015-0071
Date Deposited: 11 May 2023 14:27
Last Modified: 08 Apr 2024 22:33
Cite in APA 7: Bundscherer, L., Nagel, S., Hasse, S., Tresp, H., Wende, K., Walther, R., Reuter, S., Weltmann, K.-D., Masur, K., & Lindequist, U. (2015). Non-thermal plasma treatment induces MAPK signaling in human monocytes. Open Chemistry, 13(1), 606-613. https://doi.org/10.1515/chem-2015-0071


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