Lena Bundscherer, Stefanie Nagel, Sybille Hasse, Helena Tresp, Kristian Wende, Reinhard Walther, Stephan Reuter, Klaus-Dieter Weltmann, Kai Masur et Ulrike Lindequist
Article de revue (2015)
Document publié alors que les auteurs ou autrices n'étaient pas affiliés à Polytechnique Montréal
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Abstract
The application of non-thermal atmospheric pressure plasma raises a hope for the new wound healing strategies. Next to its antibacterial effect it is known to stimulate skin cells. However, monocytes are also needed for the complex process of a wound healing. This study investigates the impact of plasma on the intracellular signaling events in the primary human monocytes. The proliferative MEK-ERK (MAPK/ERK kinase-extracellular signal-regulated kinase) pathway was activated by short plasma treatment times. In contrast, an induction of the apoptotic JNK (c-Jun N-terminal kinase) cascade as well as activation of caspase 3 were observed after long plasma exposure. These findings indicate that monocytes can be differentially stimulated by plasma treatment and may contribute to the proper wound recovery.
Mots clés
| Département: | Département de génie physique |
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| Organismes subventionnaires: | German Ministry of Education and Research |
| Numéro de subvention: | BMBF grants 03Z2DN11, BMBF grants 03Z2DN12 |
| URL de PolyPublie: | https://publications.polymtl.ca/4811/ |
| Titre de la revue: | Open Chemistry (vol. 13, no 1) |
| Maison d'édition: | De Gruyter |
| DOI: | 10.1515/chem-2015-0071 |
| URL officielle: | https://doi.org/10.1515/chem-2015-0071 |
| Date du dépôt: | 11 mai 2023 14:27 |
| Dernière modification: | 11 août 2025 00:43 |
| Citer en APA 7: | Bundscherer, L., Nagel, S., Hasse, S., Tresp, H., Wende, K., Walther, R., Reuter, S., Weltmann, K.-D., Masur, K., & Lindequist, U. (2015). Non-thermal plasma treatment induces MAPK signaling in human monocytes. Open Chemistry, 13(1), 606-613. https://doi.org/10.1515/chem-2015-0071 |
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