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3D printed microfluidic probes

Ayoola Brimmo, Pierre-Alexandre F. Goyette, Roaa Alnemari, Thomas Gervais et Mohammad A. Qasaimeh

Article de revue (2018)

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Abstract

In this work, we fabricate microfluidic probes (MFPs) in a single step by stereolithographic 3D printing and benchmark their performance with standard MFPs fabricated via glass or silicon micromachining. Two research teams join forces to introduce two independent designs and fabrication protocols, using different equipment. Both strategies adopted are inexpensive and simple (they only require a stereolithography printer) and are highly customizable. Flow characterization is performed by reproducing previously published microfluidic dipolar and microfluidic quadrupolar reagent delivery profiles which are compared to the expected results from numerical simulations and scaling laws. Results show that, for most MFP applications, printer resolution artifacts have negligible impact on probe operation, reagent pattern formation, and cell staining results. Thus, any research group with a moderate resolution (</=100 microm) stereolithography printer will be able to fabricate the MFPs and use them for processing cells, or generating microfluidic concentration gradients. MFP fabrication involved glass and/or silicon micromachining, or polymer micromolding, in every previously published article on the topic. We therefore believe that 3D printed MFPs is poised to democratize this technology. We contribute to initiate this trend by making our CAD files available for the readers to test our "print & probe" approach using their own stereolithographic 3D printers.

Sujet(s): 1900 Génie biomédical > 1900 Génie biomédical
2700 Technologie de l'information > 2700 Technologie de l'information
3100 Physique > 3100 Physique
3100 Physique > 3101 Études atomiques et moléculaires
Département: Département de génie physique
Institut de génie biomédical
Organismes subventionnaires: Fonds de Recherche du Québec (FRQ), CRSNG/NSERC, New York University Abu Dhabi
Numéro de subvention: RGPIN-06409
URL de PolyPublie: https://publications.polymtl.ca/4807/
Titre de la revue: Scientific Reports (vol. 8, no 1)
Maison d'édition: Springer Nature
DOI: 10.1038/s41598-018-29304-x
URL officielle: https://doi.org/10.1038/s41598-018-29304-x
Date du dépôt: 13 juil. 2021 10:14
Dernière modification: 19 mai 2023 20:17
Citer en APA 7: Brimmo, A., Goyette, P.-A. F., Alnemari, R., Gervais, T., & Qasaimeh, M. A. (2018). 3D printed microfluidic probes. Scientific Reports, 8(1). https://doi.org/10.1038/s41598-018-29304-x

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