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3D printed microfluidic probes

Ayoola Brimmo, Pierre-Alexandre F. Goyette, Roaa Alnemari, Thomas Gervais, Mohammad A. Qasaimeh

Article (2018)

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Abstract

In this work, we fabricate microfluidic probes (MFPs) in a single step by stereolithographic 3D printing and benchmark their performance with standard MFPs fabricated via glass or silicon micromachining. Two research teams join forces to introduce two independent designs and fabrication protocols, using different equipment. Both strategies adopted are inexpensive and simple (they only require a stereolithography printer) and are highly customizable. Flow characterization is performed by reproducing previously published microfluidic dipolar and microfluidic quadrupolar reagent delivery profiles which are compared to the expected results from numerical simulations and scaling laws. Results show that, for most MFP applications, printer resolution artifacts have negligible impact on probe operation, reagent pattern formation, and cell staining results. Thus, any research group with a moderate resolution (</=100 microm) stereolithography printer will be able to fabricate the MFPs and use them for processing cells, or generating microfluidic concentration gradients. MFP fabrication involved glass and/or silicon micromachining, or polymer micromolding, in every previously published article on the topic. We therefore believe that 3D printed MFPs is poised to democratize this technology. We contribute to initiate this trend by making our CAD files available for the readers to test our "print & probe" approach using their own stereolithographic 3D printers.
Subjects: 1900 Biomedical engineering > 1900 Biomedical engineering
2700 Information technology > 2700 Information technology
3100 Physics > 3100 Physics
3100 Physics > 3101 Atomic and molecular studies
Department: Department of Engineering Physics
Institut de génie biomédical
Funders: Fonds de Recherche du Québec (FRQ), CRSNG/NSERC, New York University Abu Dhabi
Grant number: RGPIN-06409
PolyPublie URL: https://publications.polymtl.ca/4807/
Journal Title: Scientific Reports (vol. 8, no. 1)
Publisher: Springer Nature
DOI: 10.1038/s41598-018-29304-x
Official URL: https://doi.org/10.1038/s41598-018-29304-x
Date Deposited: 13 Jul 2021 10:14
Last Modified: 11 Nov 2022 14:21
Cite in APA 7: Brimmo, A., Goyette, P.-A. F., Alnemari, R., Gervais, T., & Qasaimeh, M. A. (2018). 3D printed microfluidic probes. Scientific Reports, 8(1). https://doi.org/10.1038/s41598-018-29304-x

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