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Recruitment of the left precentral gyrus in reading epilepsy: A multimodal neuroimaging study

Dima Safi, Renee Béland, Dang Khoa Nguyen, Philippe Pouliot, Ismail S Mohamed, Phetsamone Vannasing, Julie Tremblay, Maryse Lassonde and Anne Gallagher

Article (2016)

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PURPOSE: In a previous study, we investigated a 42-year-old male patient with primary reading epilepsy using continuous video-electroencephalography (EEG). Reading tasks induced left parasagittal spikes with a higher spike frequency when the phonological reading pathway was recruited compared to the lexical one. Here, we seek to localize the epileptogenic focus in the same patient as a function of reading pathway using multimodal neuroimaging. METHODS AND RESULTS: The participant read irregular words and nonwords presented in a block-design paradigm during magnetoencephalography (MEG), functional near-infrared spectroscopy (fNIRS), and functional magnetic resonance imaging (fMRI) recordings, all combined with EEG. Spike analyses from MEG, fNIRS, and fMRI-EEGs data revealed an epileptic focus in the left precentral gyrus, and spike localization did not differ in lexical and phonological reading. CONCLUSION: This study is the first to investigate ictogenesis in reading epilepsy during both lexical and phonological reading while using three different multimodal neuroimaging techniques. The somatosensory and motor control functions of the left precentral gyrus that are congruently involved in lexical as well as phonological reading can explain the identical spike localization in both reading pathways. The concurrence between our findings in this study and those from our previous one supports the role of the left precentral gyrus in phonological output computation as well as seizure activity in a case of reading epilepsy.

Uncontrolled Keywords

Ictogenesis; Left precentral gyrus; Lexical reading; Multimodal neuroimaging; Phonological reading; Reading epilepsy

Subjects: 1900 Biomedical engineering > 1900 Biomedical engineering
2500 Electrical and electronic engineering > 2500 Electrical and electronic engineering
9000 Health sciences > 9000 Health sciences
Department: Department of Electrical Engineering
Funders: Canadian Institute of Health Research (CIHR), Fonds de la Recherche Québécois en Santé (FRQS), Social Sciences and Humanities Research Council of Canada (SSHRC), Canada Research Chair, Fondation de l'Hôpital Ste-Justine, Fondation des Etoiles, Fondation Desjardins
Grant number: 26804, MSH-131472, 31040, MOP-133643, 206863
PolyPublie URL: https://publications.polymtl.ca/3613/
Journal Title: Epilepsy & Behavior Case Reports (vol. 5)
Publisher: Elsevier
DOI: 10.1016/j.ebcr.2016.01.003
Official URL: https://doi.org/10.1016/j.ebcr.2016.01.003
Date Deposited: 17 Jan 2019 14:13
Last Modified: 11 May 2023 19:38
Cite in APA 7: Safi, D., Béland, R., Nguyen, D. K., Pouliot, P., Mohamed, I. S., Vannasing, P., Tremblay, J., Lassonde, M., & Gallagher, A. (2016). Recruitment of the left precentral gyrus in reading epilepsy: A multimodal neuroimaging study. Epilepsy & Behavior Case Reports, 5, 19-22. https://doi.org/10.1016/j.ebcr.2016.01.003


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