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Gut microbiota influences pathological angiogenesis in obesity‐driven choroidal neovascularization

Elisabeth MMA Andriessen, Ariel M Wilson, Gaelle Mawambo, Agnieszka Dejda, Khalil Miloudi, Florian Sennlaub and Przemyslaw Sapieha

Article (2016)

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Age-related macular degeneration in its neovascular form (NV AMD) is the leading cause of vision loss among adults above the age of 60. Epidemiological data suggest that in men, overall abdominal obesity is the second most important environmental risk factor after smoking for progression to late-stage NV AMD. To date, the mechanisms that underscore this observation remain ill-defined. Given the impact of high-fat diets on gut microbiota, we investigated whether commensal microbes influence the evolution of AMD. Using mouse models of NV AMD, microbiotal transplants, and other paradigms that modify the gut microbiome, we uncoupled weight gain from confounding factors and demonstrate that high-fat diets exacerbate choroidal neovascularization (CNV) by altering gut microbiota. Gut dysbiosis leads to heightened intestinal permeability and chronic low-grade inflammation characteristic of inflammaging with elevated production of IL-6, IL-1,TNF-, and VEGF-A that ultimately aggravate pathological angiogenesis.

Uncontrolled Keywords

age‐related macular degeneration; angiogenesis; gut microbiota; inflammaging; obesity; Animals; Choroidal Neovascularization; Cytokines; Diet, High-Fat; Disease Models, Animal; Dysbiosis; Fecal Microbiota Transplantation; Gastrointestinal Microbiome; Gastrointestinal Tract; Inflammation; Macular Degeneration; Mice; Neovascularization, Pathologic; Obesity; Cytokines

Subjects: 3100 Physics > 3100 Physics
5200 Microbiology > 5200 Microbiology
5200 Microbiology > 5201 Bacteriology
Department: Department of Engineering Physics
Funders: Canadian Institutes of Health Research, Canadian Diabetes Association, CRSNG/NSERC, Fondation de l’Avenir, Paris, France, Wolfe Professorship in Translational Vision Research and the Canada Research Chair in Retinal Cell Biology, Alcon Research Institute Young Investigator Award, Foundation Fighting Blindness Canada (FFB)
Grant number: 324573, OG-3-11-3329-PS, 418637, AP-RMA-2015-010
PolyPublie URL: https://publications.polymtl.ca/3498/
Journal Title: EMBO Molecular Medicine (vol. 8, no. 12)
Publisher: EMBO Press
DOI: 10.15252/emmm.201606531
Official URL: https://doi.org/10.15252/emmm.201606531
Date Deposited: 26 Oct 2018 15:18
Last Modified: 16 May 2023 16:07
Cite in APA 7: Andriessen, E. M.M.A., Wilson, A. M., Mawambo, G., Dejda, A., Miloudi, K., Sennlaub, F., & Sapieha, P. (2016). Gut microbiota influences pathological angiogenesis in obesity‐driven choroidal neovascularization. EMBO Molecular Medicine, 8(12), 1366. https://doi.org/10.15252/emmm.201606531


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