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Gut microbiota influences pathological angiogenesis in obesity‐driven choroidal neovascularization

Elisabeth MMA Andriessen, Ariel M Wilson, Gaelle Mawambo, Agnieszka Dejda, Khalil Miloudi, Florian Sennlaub and Przemyslaw Sapieha

Article (2016)

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Cite this document: Andriessen, E. M.M.A., Wilson, A. M., Mawambo, G., Dejda, A., Miloudi, K., Sennlaub, F. & Sapieha, P. (2016). Gut microbiota influences pathological angiogenesis in obesity‐driven choroidal neovascularization. EMBO Molecular Medicine, 8(12), p. 1366. doi:10.15252/emmm.201606531
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Age-related macular degeneration in its neovascular form (NV AMD) is the leading cause of vision loss among adults above the age of 60. Epidemiological data suggest that in men, overall abdominal obesity is the second most important environmental risk factor after smoking for progression to late-stage NV AMD. To date, the mechanisms that underscore this observation remain ill-defined. Given the impact of high-fat diets on gut microbiota, we investigated whether commensal microbes influence the evolution of AMD. Using mouse models of NV AMD, microbiotal transplants, and other paradigms that modify the gut microbiome, we uncoupled weight gain from confounding factors and demonstrate that high-fat diets exacerbate choroidal neovascularization (CNV) by altering gut microbiota. Gut dysbiosis leads to heightened intestinal permeability and chronic low-grade inflammation characteristic of inflammaging with elevated production of IL-6, IL-1,TNF-, and VEGF-A that ultimately aggravate pathological angiogenesis.

Uncontrolled Keywords

age‐related macular degeneration; angiogenesis; gut microbiota; inflammaging; obesity; Animals; Choroidal Neovascularization; Cytokines; Diet, High-Fat; Disease Models, Animal; Dysbiosis; Fecal Microbiota Transplantation; Gastrointestinal Microbiome; Gastrointestinal Tract; Inflammation; Macular Degeneration; Mice; Neovascularization, Pathologic; Obesity; Cytokines

Open Access document in PolyPublie
Subjects: 3100 Physique > 3100 Physique
5200 Microbiologie > 5200 Microbiologie
5200 Microbiologie > 5201 Bactériologie
Department: Département de génie physique
Research Center: Non applicable
Funders: Canadian Institutes of Health Research, Canadian Diabetes Association, CRSNG/NSERC, Fondation de l’Avenir, Paris, France, Wolfe Professorship in Translational Vision Research and the Canada Research Chair in Retinal Cell Biology, Alcon Research Institute Young Investigator Award, Foundation Fighting Blindness Canada (FFB)
Grant number: 324573, OG-3-11-3329-PS, 418637, AP-RMA-2015-010
Date Deposited: 26 Oct 2018 15:18
Last Modified: 08 Apr 2021 10:43
PolyPublie URL: https://publications.polymtl.ca/3498/
Document issued by the official publisher
Journal Title: EMBO Molecular Medicine (vol. 8, no. 12)
Publisher: EMBO Press
Official URL: https://doi.org/10.15252/emmm.201606531


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