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A Facile Approach for the Mass Production of Submicro/Micro Poly (Lactic Acid) Fibrous Mats and Their Cytotoxicity Test towards Neural Stem Cells

Afra Hadjizadeh, Houman Savoji and Abdellah Ajji

Article (2016)

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Despite many of the studies being conducted, the electrospinning of poly (lactic acid) (PLA), dissolved in its common solvents, is difficult to be continuously processed for mass production. This is due to the polymer solution droplet drying. Besides, the poor stretching capability of the polymer solution limits the production of small diameter fibers. To address these issues, we have examined the two following objectives: first, using an appropriate solvent system for the mass production of fibrousmats with fine tunable fiber diameters; second, nontoxicity of the mats towards Neural Stem Cell (NSC). To this aim, TFA(trifluoroacetic acid) was used as a cosolvent, in a mixture with DCM(dichloromethane), and the solution viscosity, surface tension, electrical conductivity, and the continuity of the electrospinning process were compared with the solutions prepared with common single solvents. The binary solvent facilitated PLA electrospinning, resulting in a long lasting, stable electrospinning condition, due to the low surface tension and high conductivity of the binary-solvent system. The fiber diameter was tailored from nano to micro by varying effective parameters and examined by scanning electron microscopy (SEM) and image-processing software. Laminin-coated electrospun mats supported NSC expansion and spreading, as examined using AlamarBlue assay and fluorescent microscopy, respectively.

Uncontrolled Keywords

Cell Line; Cell Survival; Humans; Materials Testing; Neural Stem Cells; Polyesters; Porosity; Polyesters; poly(lactide)

Subjects: 1800 Chemical engineering > 1800 Chemical engineering
Department: Department of Chemical Engineering
Research Center: CREPEC - Center for Applied Research on Polymers and Composites
Funders: CRSNG / NSERC
PolyPublie URL: https://publications.polymtl.ca/3495/
Journal Title: BioMed Research International (vol. 2016)
Publisher: Hindawi Publishing Corporation
DOI: 10.1155/2016/8921316
Official URL: https://doi.org/10.1155/2016/8921316
Date Deposited: 25 Oct 2018 16:14
Last Modified: 30 Sep 2023 08:51
Cite in APA 7: Hadjizadeh, A., Savoji, H., & Ajji, A. (2016). A Facile Approach for the Mass Production of Submicro/Micro Poly (Lactic Acid) Fibrous Mats and Their Cytotoxicity Test towards Neural Stem Cells. BioMed Research International, 2016, 1-12. https://doi.org/10.1155/2016/8921316


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