Mohammadali Safavieh, Mohammad A. Qasaimeh, Ali Vakil, David Juncker et Thomas Gervais
Article de revue (2015)
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Abstract
A microfluidic probe (MFP) is a mobile channel-less microfluidic system under which a fluid is injected from an aperture into an open space, hydrodynamically confined by a surrounding fluid, and entirely re-aspirated into a second aperture. Various MFPs have been developed, and have been used for applications ranging from surface patterning of photoresists to local perfusion of organotypic tissue slices. However, the hydrodynamic and mass transfer properties of the flow under the MFP have not been analyzed, and the flow parameters are adjusted empirically. Here, we present an analytical model describing the key transport properties in MFP operation, including the dimensions of the hydrodynamic flow confinement (HFC) area, diffusion broadening, and shear stress as a function of: (i) probe geometry (ii) aspiration-to-injection flow rate ratio (iii) gap between MFP and substrate and (iv) reagent diffusivity. Analytical results and scaling laws were validated against numerical simulations and experimental results from published data. These results will be useful to guide future MFP design and operation, notably to control the MFP "brush stroke" while preserving shear-sensitive cells and tissues.
Mots clés
Algorithms; Microfluidic Analytical Techniques; Microfluidics; Models, Theoretical
Sujet(s): |
2700 Technologie de l'information > 2713 Algorithmes 3100 Physique > 3100 Physique |
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Département: | Département de génie physique |
Centre de recherche: | Autre |
Organismes subventionnaires: | Fonds québécois de la recherche sur la nature et les technologies (FQRNT), CRSNG / NSERC, ISS / NSERC-CREATE, Canada Research Chair |
URL de PolyPublie: | https://publications.polymtl.ca/3490/ |
Titre de la revue: | Scientific Reports (vol. 5, no 1) |
Maison d'édition: | Nature Publishing Group |
DOI: | 10.1038/srep11943 |
URL officielle: | https://doi.org/10.1038/srep11943 |
Date du dépôt: | 23 nov. 2018 10:20 |
Dernière modification: | 02 oct. 2023 10:58 |
Citer en APA 7: | Safavieh, M., Qasaimeh, M. A., Vakil, A., Juncker, D., & Gervais, T. (2015). Two-Aperture Microfluidic Probes as Flow Dipoles: Theory and Applications. Scientific Reports, 5(1). https://doi.org/10.1038/srep11943 |
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