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A Feasibility Study for Microwave Breast Cancer Detection Using Contrast-Agent-Loaded Bacterial Microbots

Panagiotis Kosmas, Yifan Chen and Sylvain Martel

Article (2013)

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Cite this document: Kosmas, P., Chen, Y. & Martel, S. (2013). A Feasibility Study for Microwave Breast Cancer Detection Using Contrast-Agent-Loaded Bacterial Microbots. International Journal of Antennas and Propagation, 2013, p. 1-11. doi:10.1155/2013/309703
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Abstract

We propose a new approach to microwave breast tumor sensing and diagnosis based on the use of biocompatible flagellated magnetotactic bacteria (MTB) adapted to operate in human microvasculature. It has been verified experimentally by Martel et al. that externally generated magnetic gradients could be applied to guide the MTB along preplanned routes inside the human body, and a nanoload could be attached to these bacterial microbots. Motivated by these useful properties, we suggest loading a nanoscale microwave contrast agent such as carbon nanotubes (CNTs) or ferroelectric nanoparticles (FNPs) onto the MTB in order to modify the dielectric properties of tissues near the agent-loaded bacteria. Subsequently, we propose a novel differential microwave imaging (DMI) technique to track simultaneously multiple swarms of MTB microbots injected into the breast. We also present innovative strategies to detect and localize a breast tissue malignancy and estimate its size via this DMI-trackable bacterial microrobotic system. Finally, we use an anatomically realistic numerical breast phantom as a platform to demonstrate the feasibility of this tumor diagnostic method.

Open Access document in PolyPublie
Subjects: 2500 Génie électrique et électronique > 2500 Génie électrique et électronique
2500 Génie électrique et électronique > 2520 Dispositifs, circuits et technologie hyperfréquences et d'ondes millimétriques
9000 Sciences médicales > 9000 Sciences médicales
Department: Département de génie informatique et génie logiciel
Research Center: Non applicable
Funders: 2013 Guangdong Natural Science Funds for Distinguished Young Scholar
Grant number: S2013050014223
Date Deposited: 14 Dec 2018 16:20
Last Modified: 15 Dec 2018 01:20
PolyPublie URL: https://publications.polymtl.ca/3435/
Document issued by the official publisher
Journal Title: International Journal of Antennas and Propagation (vol. 2013)
Publisher: Hindawi
Official URL: https://doi.org/10.1155/2013/309703

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