<  Back to the Polytechnique Montréal portal

Combining Pulsed and DC Gradients in a Clinical MRI-Based Microrobotic Platform to Guide Therapeutic Magnetic Agents in the Vascular Network

Sylvain Martel

Article (2013)

[img]
Preview
Published Version
Terms of Use: Creative Commons Attribution.
Download (548kB)
Cite this document: Martel, S. (2013). Combining Pulsed and DC Gradients in a Clinical MRI-Based Microrobotic Platform to Guide Therapeutic Magnetic Agents in the Vascular Network. International Journal of Advanced Robotic Systems, 10(1). doi:10.5772/53513
Show abstract Hide abstract

Abstract

Magnetic Resonance Navigation (MRN) relies on the use of an upgraded clinical Magnetic Resonance Imaging (MRI) scanner to navigate therapeutic, imaging, or diagnostic magnetic micro-agents in the vascular network. Although the high homogeneous field in the tunnel of the MRI scanner increases the magnetization of the navigable agents towards full saturation, the magnetic gradients superposed on such a high homogeneous field, generated by the Imaging Gradient Coils (IGC) typically used for MR-image slice selection, allow the induction of pulling forces to steer such agents in the targeted branches at the vessel's bifurcations. However, increasing the magnitude of such gradients leads to a significant decrease of the duty cycle, leading to a substantial reduction of the effective steering force being applied. To increase such a duty cycle, a Steering Gradient Coils (SGC) assembly capable of higher magnitudes while maintaining a 100% duty cycle can be installed at the cost of a much slower slew rate. Here, the use and the potential effectiveness of IGC and/or SGC for guiding such agents are briefly investigated on the basis of known specifications and experimental data.

Uncontrolled Keywords

Magnetic Resonance Imaging; Navigable Agents; Magnetic Force; Targeted Therapies and Diagnostics; Vascular Network

Open Access document in PolyPublie
Subjects: 2700 Technologie de l'information > 2700 Technologie de l'information
9000 Sciences médicales > 9000 Sciences médicales
Department: Département de génie informatique et génie logiciel
Research Center: Non applicable
Funders: École Polytechnique Research Chair in Nanorobotics, CRSNG / NSERC, Canada Foundation for Innovation (CFI)
Date Deposited: 06 Dec 2018 12:22
Last Modified: 07 Dec 2018 01:20
PolyPublie URL: https://publications.polymtl.ca/3432/
Document issued by the official publisher
Journal Title: International Journal of Advanced Robotic Systems (vol. 10, no. 1)
Publisher: Sage Publications
Official URL: https://doi.org/10.5772/53513

Statistics

Total downloads

Downloads per month in the last year

Origin of downloads

Dimensions

Repository Staff Only