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Ozone oxidation of antidepressants in wastewater – Treatment evaluation and characterization of new by-products by LC-QToFMS

André Lajeunesse, Mireille Blais, Benoit Barbeau, Sébastien Sauvé and Christian Gagnon

Article (2013)

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Terms of Use: Creative Commons Attribution.
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Cite this document: Lajeunesse, A., Blais, M., Barbeau, B., Sauvé, S. & Gagnon, C. (2013). Ozone oxidation of antidepressants in wastewater – Treatment evaluation and characterization of new by-products by LC-QToFMS. Chemistry Central Journal, 7. doi:10.1186/1752-153x-7-15
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Background: The fate of 14 antidepressants along with their respective N-desmethyl metabolites and the anticonvulsive drug carbamazepine was examined in a primary sewage treatment plant (STP) and following advanced treatments with ozone (O-3). The concentrations of each pharmaceutical compound were determined in raw sewage, effluent and sewage sludge samples by LC-MS/MS analysis. The occurrence of antidepressant by-products formed in treated effluent after ozonation was also investigated. Results: Current primary treatments using physical and chemical processes removed little of the compounds (mean removal efficiency: 19%). Experimental sorption coefficients (K-d) of each studied compounds were also calculated. Sorption of venlafaxine, desmethylvenlafaxine, and carbamazepine on sludge was assumed to be negligible (log K-d &lt;= 2), but higher sorption behavior can be expected for sertraline (log K-d &gt;= 4). Ozonation treatment with O-3 (5 mg/L) led to a satisfactory mean removal efficiency of 88% of the compounds. Screening of the final ozone-treated effluent samples by high resolution-mass spectrometry (LC-QqToFMS) did confirm the presence of related N-oxide by-products. Conclusion: Effluent ozonation led to higher mean removal efficiencies than current primary treatment, and therefore represented a promising strategy for the elimination of antidepressants in urban wastewaters. However, the use of O-3 produced by-products with unknown toxicity.

Uncontrolled Keywords

Sewage; Waste Water; Carbamazepine; Oxides; Anticonvulsants; Ozone; Sertraline; Chemical Processes; Therapeutics; Mass Spectrometry; Chemistry/Food Science; general; Antidepressants; Ozone; LC-MS/MS; Sewage treatment plants; Biosolids; Side-products

Open Access document in PolyPublie
Subjects: 1000 Génie civil > 1000 Génie civil
1500 Génie de l'environnement > 1500 Génie de l'environnement
1500 Génie de l'environnement > 1502 Traitement des eaux usées
Department: Département des génies civil, géologique et des mines
Research Center: Non applicable
Funders: Chemical Management Plan (Health Canada and St. Lawrence Action Plan)
Date Deposited: 06 Dec 2018 12:20
Last Modified: 07 Dec 2018 01:20
PolyPublie URL: https://publications.polymtl.ca/3429/
Document issued by the official publisher
Journal Title: Chemistry Central Journal (vol. 7)
Publisher: BioMed Central Ltd
Official URL: https://doi.org/10.1186/1752-153x-7-15


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