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Ozone oxidation of antidepressants in wastewater – Treatment evaluation and characterization of new by-products by LC-QToFMS

André Lajeunesse, Mireille Blais, Benoit Barbeau, Sébastien Sauvé and Christian Gagnon

Article (2013)

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Abstract

Background: The fate of 14 antidepressants along with their respective N-desmethyl metabolites and the anticonvulsive drug carbamazepine was examined in a primary sewage treatment plant (STP) and following advanced treatments with ozone (O-3). The concentrations of each pharmaceutical compound were determined in raw sewage, effluent and sewage sludge samples by LC-MS/MS analysis. The occurrence of antidepressant by-products formed in treated effluent after ozonation was also investigated. Results: Current primary treatments using physical and chemical processes removed little of the compounds (mean removal efficiency: 19%). Experimental sorption coefficients (K-d) of each studied compounds were also calculated. Sorption of venlafaxine, desmethylvenlafaxine, and carbamazepine on sludge was assumed to be negligible (log K-d &lt;= 2), but higher sorption behavior can be expected for sertraline (log K-d &gt;= 4). Ozonation treatment with O-3 (5 mg/L) led to a satisfactory mean removal efficiency of 88% of the compounds. Screening of the final ozone-treated effluent samples by high resolution-mass spectrometry (LC-QqToFMS) did confirm the presence of related N-oxide by-products. Conclusion: Effluent ozonation led to higher mean removal efficiencies than current primary treatment, and therefore represented a promising strategy for the elimination of antidepressants in urban wastewaters. However, the use of O-3 produced by-products with unknown toxicity.

Uncontrolled Keywords

Sewage; Waste Water; Carbamazepine; Oxides; Anticonvulsants; Ozone; Sertraline; Chemical Processes; Therapeutics; Mass Spectrometry; Chemistry/Food Science; general; Antidepressants; Ozone; LC-MS/MS; Sewage treatment plants; Biosolids; Side-products

Subjects: 1000 Civil engineering > 1000 Civil engineering
1500 Environmental engineering > 1500 Environmental engineering
1500 Environmental engineering > 1502 Waste water treatment
Department: Department of Civil, Geological and Mining Engineering
Funders: Chemical Management Plan (Health Canada and St. Lawrence Action Plan)
PolyPublie URL: https://publications.polymtl.ca/3429/
Journal Title: Chemistry Central Journal (vol. 7, no. 1)
Publisher: BioMed Central Ltd
DOI: 10.1186/1752-153x-7-15
Official URL: https://doi.org/10.1186/1752-153x-7-15
Date Deposited: 06 Dec 2018 12:20
Last Modified: 07 Nov 2023 11:21
Cite in APA 7: Lajeunesse, A., Blais, M., Barbeau, B., Sauvé, S., & Gagnon, C. (2013). Ozone oxidation of antidepressants in wastewater – Treatment evaluation and characterization of new by-products by LC-QToFMS. Chemistry Central Journal, 7(1). https://doi.org/10.1186/1752-153x-7-15

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