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Degradation of progestagens by oxidation with potassium permanganate in wastewater effluents

Paul B. Fayad, Arash Zamyadi, Romain Broseus, Michèle Prévost and Sébastien Sauvé

Article (2013)

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Cite this document: Fayad, P. B., Zamyadi, A., Broseus, R., Prévost, M. & Sauvé, S. (2013). Degradation of progestagens by oxidation with potassium permanganate in wastewater effluents. Chemistry Central Journal, 7. doi:10.1186/1752-153x-7-84
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Abstract

Background: This study investigated the oxidation of selected progestagenic steroid hormones by potassium permanganate at pH 6.0 and 8.0 in ultrapure water and wastewater effluents, using bench-scale assays. Second order rate constants for the reaction of potassium permanganate with progestagens (levonorgestrel, medroxyprogesterone, norethindrone and progesterone) was determined as a function of pH, presence of natural organic matter and temperature. This work also illustrates the advantages of using a novel analytical method, the laser diode thermal desorption (LDTD-APCI) interface coupled to tandem mass spectrometry apparatus, allowing for the quick determination of oxidation rate constants and increasing sample throughput. Results: The second-order rate constants for progestagens with permanganate determined in bench-scale experiments ranged from 23 to 368 M-1 sec(-1) in both wastewater and ultrapure waters with pH values of 6.0 and 8.0. Two pairs of progestagens exhibited similar reaction rate constants, i.e. progesterone and medroxyprogesterone (23 to 80 M-1 sec(-1) in ultrapure water and 26 to 149 M-1 sec(-1) in wastewaters, at pH 6.0 and 8.0) and levonorgestrel and norethindrone (179 to 224 M-1 sec(-1) in ultrapure water and 180 to 368 M-1 sec(-1) in wastewaters, at pH 6.0 and 8.0). The presence of dissolved natural organic matter and the pH conditions improved the oxidation rate constants for progestagens with potassium permanganate only at alkaline pH. Reaction rates measured in Milli-Q water could therefore be used to provide conservative estimates for the oxidation rates of the four selected progestagens in wastewaters when exposed to potassium permanganate. The progestagen removal efficiencies was lower for progesterone and medroxyprogesterone (48 to 87%) than for levonorgestrel and norethindrone (78 to 97%) in Milli-Q and wastewaters at pH 6.0-8.2 using potassium permanganate dosages of 1 to 5 mg L-1 after contact times of 10 to 60 min. Conclusion: This work presents the first results on the permanganate-promoted oxidation of progestagens, as a function of pH, temperature as well as NOM. Progestagen concentrations used to determine rate constants were analyzed using an ultrafast laser diode thermal desorption interface coupled to tandemmass spectrometry for the analysis of water sample for progestagens.

Uncontrolled Keywords

Levonorgestrel; Waste Water; Medroxyprogesterone; Water; Progestins; Steroids; Hormones; Progesterone; Potassium Permanganate; Norethindrone; Temperature; Tandem Mass Spectrometry; Lasers, Semiconductor; Chemistry/Food Science; general; Oxidation; LDTD-APCI-MSMS; Endocrine disruptors; Kinetic rate constant;

Open Access document in PolyPublie
Subjects: 1000 Génie civil > 1000 Génie civil
1500 Génie de l'environnement > 1500 Génie de l'environnement
1500 Génie de l'environnement > 1502 Traitement des eaux usées
Department: Département des génies civil, géologique et des mines
Research Center: Non applicable
Funders: CRSNG / NSERC, Industrial Chair on Drinking Water, Canadian Foundation for Innovation
Date Deposited: 06 Dec 2018 12:18
Last Modified: 07 Dec 2018 01:20
PolyPublie URL: https://publications.polymtl.ca/3428/
Document issued by the official publisher
Journal Title: Chemistry Central Journal (vol. 7)
Publisher: BioMed Central Ltd
Official URL: https://doi.org/10.1186/1752-153x-7-84

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