Elise Deshommes, Robert Tardif, Marc Edwards, Sébastien Sauvé and Michèle Prévost
Article (2012)
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Published Version Terms of Use: Creative Commons Attribution . Download (935kB) |
Cite this document: | Deshommes, E., Tardif, R., Edwards, M., Sauvé, S. & Prévost, M. (2012). Experimental determination of the oral bioavailability and bioaccessibility of lead particles. Chemistry Central Journal, 6. doi:10.1186/1752-153x-6-138 |
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Abstract
In vivo estimations of Pb particle bioavailability are costly and variable, because of the nature of animal assays. The most feasible alternative for increasing the number of investigations carried out on Pb particle bioavailability is in vitro testing. This testing method requires calibration using in vivo data on an adapted animal model, so that the results will be valid for childhood exposure assessment. Also, the test results must be reproducible within and between laboratories. The Relative Bioaccessibility Leaching Procedure, which is calibrated with in vivo data on soils, presents the highest degree of validation and simplicity. This method could be applied to Pb particles, including those in paint and dust, and those in drinking water systems, which although relevant, have been poorly investigated up to now for childhood exposure assessment.
Uncontrolled Keywords
Oral bioavailability; Bioaccessibility; Lead [Pb] particles; In vivo tests; In vitro tests
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Subjects: |
1000 Génie civil > 1000 Génie civil 1500 Génie de l'environnement > 1501 Qualité de l'eau, pollution 9000 Sciences de la santé > 9000 Sciences de la santé |
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Department: | Département des génies civil, géologique et des mines |
Research Center: | Non applicable |
Funders: | Canadian Water Network, CRSNG / NSERC, Canada Industrial Chair on Drinking Water, City of Montreal, Ville de Laval, JMI-Veolia |
Date Deposited: | 03 Dec 2018 12:18 |
Last Modified: | 08 Apr 2021 10:43 |
PolyPublie URL: | https://publications.polymtl.ca/3417/ |
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Journal Title: | Chemistry Central Journal (vol. 6) |
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Publisher: | BioMed Central Ltd |
Official URL: | https://doi.org/10.1186/1752-153x-6-138 |
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