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Experimental determination of the oral bioavailability and bioaccessibility of lead particles

Elise Deshommes, Robert Tardif, Marc Edwards, Sébastien Sauvé and Michèle Prévost

Article (2012)

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Cite this document: Deshommes, E., Tardif, R., Edwards, M., Sauvé, S. & Prévost, M. (2012). Experimental determination of the oral bioavailability and bioaccessibility of lead particles. Chemistry Central Journal, 6. doi:10.1186/1752-153x-6-138
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Abstract

In vivo estimations of Pb particle bioavailability are costly and variable, because of the nature of animal assays. The most feasible alternative for increasing the number of investigations carried out on Pb particle bioavailability is in vitro testing. This testing method requires calibration using in vivo data on an adapted animal model, so that the results will be valid for childhood exposure assessment. Also, the test results must be reproducible within and between laboratories. The Relative Bioaccessibility Leaching Procedure, which is calibrated with in vivo data on soils, presents the highest degree of validation and simplicity. This method could be applied to Pb particles, including those in paint and dust, and those in drinking water systems, which although relevant, have been poorly investigated up to now for childhood exposure assessment.

Uncontrolled Keywords

Oral bioavailability; Bioaccessibility; Lead [Pb] particles; In vivo tests; In vitro tests

Open Access document in PolyPublie
Subjects: 1000 Génie civil > 1000 Génie civil
1500 Génie de l'environnement > 1501 Qualité de l'eau, pollution
9000 Sciences médicales > 9000 Sciences médicales
Department: Département des génies civil, géologique et des mines
Research Center: Non applicable
Funders: Canadian Water Network, CRSNG / NSERC, Canada Industrial Chair on Drinking Water, City of Montreal, Ville de Laval, JMI-Veolia
Date Deposited: 03 Dec 2018 12:18
Last Modified: 04 Dec 2018 01:20
PolyPublie URL: https://publications.polymtl.ca/3417/
Document issued by the official publisher
Journal Title: Chemistry Central Journal (vol. 6)
Publisher: BioMed Central Ltd
Official URL: https://doi.org/10.1186/1752-153x-6-138

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