Élise Deshommes, Robert Tardif, Marc Edwards, Sébastien Sauvé et Michèle Prévost
Article de revue (2012)
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Abstract
In vivo estimations of Pb particle bioavailability are costly and variable, because of the nature of animal assays. The most feasible alternative for increasing the number of investigations carried out on Pb particle bioavailability is in vitro testing. This testing method requires calibration using in vivo data on an adapted animal model, so that the results will be valid for childhood exposure assessment. Also, the test results must be reproducible within and between laboratories. The Relative Bioaccessibility Leaching Procedure, which is calibrated with in vivo data on soils, presents the highest degree of validation and simplicity. This method could be applied to Pb particles, including those in paint and dust, and those in drinking water systems, which although relevant, have been poorly investigated up to now for childhood exposure assessment.
Mots clés
Oral bioavailability; Bioaccessibility; Lead [Pb] particles; In vivo tests; In vitro tests
Sujet(s): |
1000 Génie civil > 1000 Génie civil 1500 Génie de l'environnement > 1501 Qualité de l'eau, pollution 9000 Sciences de la santé > 9000 Sciences de la santé |
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Département: | Département des génies civil, géologique et des mines |
Organismes subventionnaires: | Canadian Water Network, CRSNG / NSERC, Canada Industrial Chair on Drinking Water, City of Montreal, Ville de Laval, JMI-Veolia |
URL de PolyPublie: | https://publications.polymtl.ca/3417/ |
Titre de la revue: | Chemistry Central Journal (vol. 6, no 1) |
Maison d'édition: | BioMed Central Ltd |
DOI: | 10.1186/1752-153x-6-138 |
URL officielle: | https://doi.org/10.1186/1752-153x-6-138 |
Date du dépôt: | 03 déc. 2018 12:18 |
Dernière modification: | 27 sept. 2024 22:50 |
Citer en APA 7: | Deshommes, É., Tardif, R., Edwards, M., Sauvé, S., & Prévost, M. (2012). Experimental determination of the oral bioavailability and bioaccessibility of lead particles. Chemistry Central Journal, 6(1). https://doi.org/10.1186/1752-153x-6-138 |
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